Antidiabetic Plants of Iran

  • Asie Shojaii Mail Research Institute for Islamic and Complementary Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Fataneh Hashem Dabaghian Research Institute for Islamic and Complementary Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Ashrafeddin Goushegir Research Institute for Islamic and Complementary Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Mehri Abdollahi Fard Research Institute for Islamic and Complementary Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Diabetes mellitus, Plants, Iran, Randomized control trials


To identify the antidiabetic plants of Iran, a systematic review of the published literature on the efficacy of Iranian medicinal plant for glucose control in patients with type 2 diabetes mellitus was conducted. We performed an electronic literature search of MEDLINE, Science Direct, Scopus, Proquest, Ebsco, Googlescholar, SID, Cochrane Library Database, from 1966 up to June 2010. The search terms were complementary and alternative medicine (CAM), diabetes mellitus, plant (herb), Iran, patient, glycemic control, clinical trial, RCT, natural or herbal medicine, hypoglycemic plants, and individual herb names from popular sources, or combination of these key words. Available Randomized Controlled Trials (RCT) published in English or Persian language examined effects of an herb (limited to Iran) on glycemic indexes in type 2 diabetic patients were included. Among all of the articles identified in the initial database search, 23 trials were RCT, examining herbs as potential therapy for type 2 diabetes mellitus. The key outcome for antidiabetic effect was changes in blood glucose or HbA1 c, as well as improves in insulin sensitivity or resistance. Available data suggest that several antidiabetic plants of Iran need further study. Among the RCT studies, the best evidence in glycemic control was found in Citrullus colocynthus, Ipomoea betatas, Silybum marianum and Trigonella foenum graecum.


Rodbard HW, Blonde L, Braithwaite SS, Brett EM, Cobin RH, Handelsman Y, Hellman R, Jellinger PS, Jovanovic LG, Levy P, Mechanick JI, Zangeneh F; AACE Diabetes Mellitus Clinical Practice Guidelines Task Force. American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus. Endocr Pract 2007;13Suppl 1:1-68.

Azizi F, Guoya MM, Vazirian P, Dolatshati P, Habbibian S. Screening for type 2 diabetes in the Iranian national programme: a preliminary report. East Mediterr Health J 2003;9(5-6):1122-7.

Esteghamati A, Gouya MM, Abbasi M, Delavari A,Alikhani S, Alaedini F, Safaie A, Forouzanfar M, GreggEW. Prevalence of diabetes and impaired fasting glucose in the adult population of Iran: National Survey of Risk Factors for Non-Communicable Diseases of Iran. Diabetes Care 2008;31(1):96-8.

Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004;27(5):1047-53.

Fakhoury WK, Lereun C, Wright D. A meta-analysis of placebo-controlled clinical trials assessing the efficacy and safety of incretin-based medications in patients with type 2 diabetes. Pharmacology 2010;86(1):44-57.

Modak M, Dixit P, Londhe J, Ghaskadbi S, Paul A Devasagayam T. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr 2007;40(3):163-73.

Fallah-Hoseini H, Fakhrzadeh H, Larijani B, Shikhsamani

A. Review of anti-diabetic medicinal plant used in traditional medicine. J Med Plant 2006;5(Suppl 2):1-8.

Pandey VN, Rajagopalan SS, Chowdhary DP. An effective Ayurvedic hypoglycemic formulation. J Res AyurvedaSiddha 1995;16(1-2):1-14.

O'Connell, Belinda S. Select vitamins and minerals in thetreatment of diabetes. Diabetes Spectrum 2001;14:133-48.

Shane-McWhorter L. Biological complementary therapies: a focus on botanical products in diabetes. Diabetes Spectrum 2001;14(4):199-208.

Mooradian AD, Failla M, Hoogwerf B, Maryniuk M, Wylie-Rosett J. Selected vitamins and minerals in diabetes.Diabetes Care 1994;17(5):464-79.

Bailey CJ, Day C. Traditional plant medicines as treatments for diabetes. Diabetes Care 1989;12(8):553-64.

Chitwood M. Botanical therapies for diabetes: on the cutting edge. Diabetes Care Edu 1999;20:3-20.

Morelli V, Zoorob RJ. Alternative therapies: Part I. Depression, diabetes, obesity. Am Fam Physician 2000;62(5):1051-60.

Berman BM, Swyers JP, Kaczmarczyk J. Complementary and alternative medicine: herbal therapies for diabetes. J Assoc Acad Minor Phys 1999;10(1):10-4.

Gori M, Campbell RK. Natural products and diabetes treatment. Diabetes Educ 1998;24(2):201-2, 205-8.

Ernst E. Hypoglycaemic plant medicines. Perfusion 1996;9(11):416-8.

ErnstE. Plants with hypoglycemic activity in humans.Phytomedicine 1997;4(1):73-8.

Hasani-Ranjbar Sh, Larijani B, Abdollahi M. A systematicReview of Iranian medicinal plants useful in diabetesmellitus. Arch Med Sci 2008;4(3):285–92.

Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS.Systematic review of herbs and dietary supplements forglycemic control in diabetes. Diabetes Care 2003;26(4):1277-94.

Ghahreman A. Flora of Iran. Ministry of Reconstruction,Jahad Research Institute of Forects and Rangelands, 2005.

Rechinger KH. Flora Iranica. Graz-Austria: Akademische Druck Press; 1982. p. 439-40.

Mozaffarian V. Dictionary of Iranian Plant Names. (Latin- English-Persian). 3rd ed. Tehran: Farhang Moaser Publication; 2003.

Fallah Hoseini H, Heshmat R, Larijani B. The clinical investigation of Citrullus Colocynthis (L) Schrad Fruit in treatment of type II diabetic patients: Arandomized double-blind, placebo-controlled study. J Med Plant 2005;5:31-5.

Fallah Hoseini H, Zarei BA, Heshmat R. The effect ofCitrullus Colocynthis (L) Schrad fruit on oxidative stress parameters in type II diabetic patients. J Med Plant2005;5:55-60.

Huseini HF, Darvishzadeh F, Heshmat R, Jafariazar Z, Raza M, Larijani B. The clinical investigation of Citrullus colocynthis (L.) schrad fruit in treatment of Type II diabetic patients: a randomized, double blind, placebocontrolled clinical trial. Phytother Res 2009;23(8):1186-9.

Ludvik B, Waldhäusl W, Prager R, Kautzky-Willer A, Pacini G. Mode of action of ipomoea batatas (Caiapo) in type 2 diabetic patients. Metabolism 2003;52(7):875-80.

Ludvik B, Neuffer B, Pacini G. Efficacy of Ipomoea batatas (Caiapo) on diabetes control in type 2 diabetic subjects treated with diet. Diabetes Care 2004;27(2):436-40.

Fallah Hoseini H, Larijani B, Fakhrzadeh H. The clinical trial of Silybum Marianum seed extract (Silymarin) on type II diabetic patients with hyperlipidemia. Iran J Diabet Lipid Dis 2004;3:78.

Huseini HF, Larijani B, Heshmat R, Fakhrzadeh H, Radjabipour B, Toliat T, Raza M. The efficacy of Silybum marianum (L.) Gaertn. (silymarin) in the treatment of typeII diabetes: a randomized, double-blind, placebocontrolled, clinical trial. Phytother Res 2006;20(12):1036-9.

Velussi M, Cernigoi AM, De Monte A, Dapas F, Caffau C, Zilli M. Long-term (12 months) treatment with an anti-oxidant drug (silymarin) is effective on hyperinsulinemia, exogenous insulin need and malondialdehyde levels in cirrhotic diabetic patients. J Hepatol 1997;26(4):871-9.

Bawadi HA, Maghaydah SN, Tayyem RF, Tayyem RF.The postprandial hypoglycemic activity of fenugreek seed and seeds extract in type 2 diabetics: A pilot study. Pharmacognosy Mag 2009;4(18):134-8.

Sharma RD, Raghuram TC. Hypoglycemic effect of Fenugreek seeds in non-insulin dependent diabetic subjects. Nutr Res 1990;10:731-9.

Lovejoy JC, Most MM, Lefevre M, Greenway FL, Rood J C. Effect of diet enriched in almonds on insulin action and serum lipids in adults with normal glucose tolerance or type 2 diabetes. Am J Clin Nutr 2002;76:1000-6.

Li SC, Liu YH, Liu JF, Chang WH, Chen CM, Chen CY. Almond consumption improved glycemic control and lipidprofiles in patients with type 2 diabetes mellitus. Metabolism 2011;60(4):474-9.

Sitprija S, Plengvidhya C, Kangkaya V, Bhuvapanich S,Tunkayoon M. Garlic and diabetes mellitus phase IIclinical trial. J Med Assoc Thai 1987;70 Suppl 2:223-7.

Andallu B, Ramaya V. Anti-hyperglycemic, cholesterollowering and HDL-raising effects of cumin (Cuminum cyminum) seeds in type 2 diabetes. J Nat Remedies 2007;7:142-9.

Kudolo GB, Wang W, Elrod R, Barrientos J, Haase A, Blodgett J. Short-term ingestion of Ginkgo biloba extract does not alter whole body insulin sensitivity in nondiabetic, pre-diabetic or type 2 diabetic subjects: a randomized double-blind placebo-controlled crossover study. Clin Nutr 2006;25(1):123-34.

Agrawal P, Rai V, Singh RB. Randomized placebocontrolled, single blind trial of holy basil leaves in patientswith noninsulin-dependent diabetes mellitus. Int J ClinPharmacol Ther 1996;34(9):406-9.

Frati AC, Gordillo BE, Altamirano P, Ariza CR, Cortés- Franco R, Chavez-Negrete A. Acute hypoglycemic effect of Opuntia streptacantha Lemaire in NIDDM. Diabetes Care 1990;13(4):455-6.

Ziai SA, Larijani B, Akhoondzadeh S, Fakhrzadeh H,Dastpak A, Bandarian F, Rezai A, Badi HN, Emami T.Psyllium decreased serum glucose and glycosylatedhemoglobin significantly in diabetic outpatients. J Ethnopharmacol 2005;102(2):202-7.

Vosough-Ghanbari S, Rahimi R, Kharabaf S, Zeinali S,Mohammadirad A, Amini S, Yasa N, Salehnia A, Toliat T,Nikfar S, Larijani B, Abdollahi M. Effects of Satureja khuzestanica on Serum Glucose, Lipids and Markers of Oxidative Stress in Patients with Type 2 Diabetes Mellitus:A Double-Blind Randomized Controlled Trial. Evid Based Complement Alternat Med 2010;7(4):465-70.

Fallah Huseini H, Hooseini P, Heshmat R, Yazdani D, Hemati Moqadam HR, Rahmani M, Larijani B, Alavi SH R. The clinical investigation of Securigera securidaca (L.) (Degen and Doerfler) seeds in type II diabetic patients; a randomized, double-blind, placebo-controlled study. J Med Plant 2006;5(20):75-9.

Fukino Y, Ikeda A, Maruyama K, Aoki N, Okubo T, Iso H. Randomized controlled trial for an effect of green teaextract powder supplementation on glucose abnormalities. Eur J Clin Nutr 2008;62(8):953-60.

Abidov M, Ramazanov A, Jimenez Del Rio M, Chkhikvishvili I. Effect of Blueberin on fasting glucose, Creactive protein and plasma aminotransferases, in female volunteers with diabetes type 2: double-blind, placebo controlled clinical study. Georgian Med News 2006;(141):66-72.

Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Van Rompay M, Kessler RC. Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA 1998;280(18):1569-75.

How to Cite
Shojaii A, Hashem Dabaghian F, Goushegir A, Abdollahi Fard M. Antidiabetic Plants of Iran. Acta Med Iran. 49(10):637-642.