Relationship between Helicobacter pylori Infection and Chronic Obstructive Pulmonary Disease
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Abstract
There is some evidence indicating the role of Helicobacter pylori infection in pathogenesis of extragastrointestinal diseases including skin, vascular, and autoimmune disorders, as well as some respiratory diseases. The aim of this study was to investigate the association between H. pylori and chronic obstructive pulmonary disease (COPD). In a case-control study, 90 patients with COPD and 90 age- and sex- matched control subjects were included. Serum samples were tested for anti-H. pylori and anti-CagA IgG by ELISA. A physician completed a questionnaire including demographic characteristics, habitual history, and spirometric findings for each patient. Of 90 patients with COPD 66 (51%) had mild, 31 (34.4%) moderate, and 13 (14.4%) sever disease. There was no significant association between H. pylori IgG seropositivity and COPD. Serum levels of anti-CagA IgG were significantly higher in patients with COPD than in the control subjects (P < 0.001). No association was observed between H. pylori infection and severity of COPD. The results suggest that there is an association between CagA-positive H. pylori infections and COPD. Further studies should be planned to investigate the potential pathogenic mechanisms that might underlie these associations.
Blaser MJ. Helicobacter pylori and other gastric Helicobacter species. In: Mandell GL, Dolin JR, Bennett R, editors. Principles and Practice of Infectious Diseases. Philadelphia: Churchill Livingstone; 2010. p. 2803-13.
Roussos A, Philippou N, Gourgoulianis KI. Helicobacter pylori infection and respiratory diseases: a review. World J Gastroenterol 2003;9(1):5-8.
Roussos A, Philippou N, Krietsepi V, Anastasakou E, Alepopoulou D, Koursarakos P, Iliopoulos I, Gourgoulianis K. Helicobacter pylori seroprevalence in patients with chronic obstructive pulmonary disease. Respir Med 2005;99(3):279-84.
Kanbay M, Gur G, Akcay S, Yilmaz U. Helicobacter pylori seroprevalence in patients with chronic bronchitis. Respir Med 2005;99(10):1213-6.
Jun ZJ, Lei Y, Shimizu Y, Dobashi K, Mori M. High seroprevalence of Helicobacter pylori in chronic bronchitisamong Chinese population. Tohoku J Exp Med2006;208(4):327-31.
Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C, Zielinski J; Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2007;176(6):532-55.
de Korwin JD. Does Helicobacter pylori infection play a role in extragastric diseases? Presse Med 2008;37(3 Pt2):525-34.
Kanbay M, Kanbay A, Boyacioglu S. Helicobacter pylori infection as a possible risk factor for respiratory system disease: a review of the literature. Respir Med 2007;101(2):203-9.
Gencer M, Ceylan E, Yildiz Zeyrek F, Aksoy N. Helicobacter pylori seroprevalence in patients with chronic obstructive pulmonary disease and its relation topulmonary function tests. Respiration 2007;74(2):170-5.
Fullerton D, Britton JR, Lewis SA, Pavord ID, McKeever TM, Fogarty AW. Helicobacter pylori and lung function, asthma, atopy and allergic disease: a population-based cross-sectional study in adults. Int J Epidemiol 2009;38(2):419-26.
Roussos A, Philippou N, Mantzaris GJ, Gourgoulianis KI. Respiratory diseases and Helicobacter pylori infection: is there a link? Respiration 2006;73(5):708-14.
Jafarzadeh A, Mirzaee V, Ahmad-Beygi H, Nemati M, Rezayati MT. Association of the CagA status of Helicobacter pylori and serum levels of interleukin (IL)-17 and IL-23 in duodenal ulcer patients. J Dig Dis 2009;10(2):107-12.
Kountouras J, Boura P, Lygidakis NJ. Omeprazole and regulation of cytokine profile in Helicobacter pyloriinfected patients with duodenal ulcer disease. Hepatogastroenterology 2000;47(35):1301-4.
Tetley TD. Inflammatory cells and chronic obstructive pulmonary disease. Curr Drug Targets Inflamm Allergy 2005;4(6):607-18.
Cornwell WD, Kim V, Song C, Rogers TJ. Pathogenesis of inflammation and repair in advanced COPD. Semin Respir Crit Care Med 2010;31(3):257-66.
Keatings VM, Collins PD, Scott DM, Barnes PJ. Differences in interleukin-8 and tumor necrosis factoralpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma. Am J Respir Crit Care Med 1996;153(2):530-4.
Kandulski A, Selgrad M, Malfertheiner P. Helicobacter pylori infection: a clinical overview. Dig Liver Dis 2008;40(8):619-26.
Kowalski M, Pawlik M, Konturek JW, Konturek SJ. Helicobacter pylori infection in coronary artery disease. J Physiol Pharmacol 2006;57 Suppl 3:101-11.
Bayraktaroğlu T, Aras AS, Aydemir S, Davutoğlu C, Ustündağ Y, Atmaca H, Borazan A. Serum levels of tumor necrosis factor-alpha, interleukin-6 and interleukin-8 are not increased in dyspeptic patients with Helicobacter pylori-associated gastritis. Mediators Inflamm 2004;13(1):25-8.
Mitz HS, Farber SS. Demonstration of Helicobacter pylori in tracheal secretions. J Am Osteopath Assoc 1993;93(1):87-91.
Gülhan M, Ozyilmaz E, Tarhan G, Demirağ F, Capan N, Ertürk A, Canbakan S, Ayaşlioğlu E, Gülhan E, Ahmed K. Helicobacter pylori in bronchiectasis: a polymerase chain reaction assay in bronchoalveolar lavage fluid and bronchiectatic lung tissue. Arch Med Res 2007;38(3):317-21.
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| Issue | Vol 49, No 11 (2011) | |
| Section | Articles | |
| Keywords | ||
| COPD Helicobacter pylori Infection | ||
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