Study to Evaluate Two Dosage Regimens of Vitamin D through an Academic Year in Middle School Girls: a Randomized Trial
-
Mehrdad Shakiba
,
Malihe Ghadir
,
Zahra Nafei
,
Sedighe Akhavan Karbasi
,
Mohammad Hassan Lotfi
,
Ahmad Shajari
Abstract
Vitamin D is an essential hormone for growth and development of bones in children. There is a lot of evidence for deficiency of this vitamin in Middle East females. This study conduct to find a way to combat deficiency in girls during rapid growth phase of puberty in academic year. One hundred and two Middle School girls who had not consumed any vitamins supplement have been participated in this randomized clinical trial. They allocated randomly in two case groups who received 50,000 or 100,000 IU vitamin D3 in October and three months later in January or in control group who received vitamin E. At the end of winter blood samples for 25-hydroxyvitamin D were checked. The mean of 25-hydroxyvitamin D were 5.5±1.5 ng/ml, 15.2±6 ng/ml, 23.0±6.8 ng/ml in control, 50,000 and 100,000 IU vitamin D groups respectively (P0.05). Urine calcium/creatinin ratio was equal in case and control groups (P>0.05). 100,000 IU of vitamin D3 every three months (equal to 800IU/day) can raise 25-hydroxyvitamin D above 12 ng/ml in all cases but for area with high prevalence of sever deficiency, dosage more than 100,000 IU every three months or shorter interval recommended to achieve optimal level.
Holick MF. Vitamin D deficiency. N Engl J Med 2007;19;357(3):266-81.
Holick MF. Vitamin D: The underappreciated D-lightful hormone that is important for skeletal and cellular health. Curr Opin Endocrinol Diabetes 2002;9(1):87-98.
Heaney RP, Dowell MS, Hale CA, Bendich A. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D. J Am Coll Nutr 2003;22(2):142-6.
Cannell JJ, Hollis BW. Use of vitamin D in clinical practice. Altern Med Rev 2008;13(1):6-20.
El-Hajj Fuleihan G, Nabulsi M, Choucair M, Salamoun M, Hajj Shahine C, Kizirian A, Tannous R. Hypovitaminosis D in healthy schoolchildren. Pediatrics 2001;107(4):E53.
Du X, Greenfield H, Fraser DR, Ge K, Trube A, Wang Y. Vitamin D deficiency and associated factors in adolescent girls in Beijing. Am J Clin Nutr 2001;74(4):494-500.
Guillemant J, Taupin P, Le HT, Taright N, Allemandou A, Pérès G, Guillemant S. Vitamin D status during puberty in French healthy male adolescents. Osteoporos Int 1999;10(3):222-5.
Rovner AJ, O'Brien KO. Hypovitaminosis D among healthy children in the United States: a review of the current evidence. Arch Pediatr Adolesc Med 2008;162(6):513-9.
Gordon CM, DePeter KC, Feldman HA, Grace E, Emans SJ. Prevalence of vitamin D deficiency among healthy adolescents. Arch Pediatr Adolesc Med 2004;158(6):531-7.
Lehtonen-Veromaa MK, Möttönen TT, Nuotio IO, Irjala KM, Leino AE, Viikari JS. Vitamin D and attainment of peak bone mass among peripubertal Finnish girls: a 3-yprospective study. Am J Clin Nutr 2002;76(6):1446-53.
Outila TA, Kärkkäinen MU, Lamberg-Allardt CJ.Vitamin D status affects serum parathyroid hormone concentrations during winter in female adolescents: associations with forearm bone mineral density. Am JClin Nutr 2001;74(2):206-10.
Looker AC, Dawson-Hughes B, Calvo MS, Gunter EW, Sahyoun NR. Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone 2002;30(5):771-7.
Das G, Crocombe S, McGrath M, Berry JL, Mughal MZ.Hypovitaminosis D among healthy adolescent girls attending an inner city school. Arch Dis Child 2006;91(7):569-72.
Huh SY, Gordon CM. Vitamin D deficiency in children and adolescents: epidemiology, impact and treatment. Rev Endocr Metab Disord 2008;9(2):161-70.
Moussavi M, Heidarpour R, Aminorroaya A, Pournaghshband Z, Amini M. Prevalence of vitamin Ddeficiency in Isfahani high school students in 2004. Horm Res 2005;64(3):144-8.
Hashemipour S, Larijani B, Adibi H, Javadi E, SedaghatM, Pajouhi M, Soltani A, Shafaei AR, Hamidi Z, Fard AR, Hossein-Nezhad A, Booya F. Vitamin D deficiency and causative factors in the population of Tehran. BMC Public Health 2004;4:38.
Maghbooli Z, Hossein-Nezhad A, Shafaei AR, Karimi F, Madani FS, Larijani B. Vitamin D status in mothers and their newborns in Iran. BMC Pregnancy Childbirth 2007;7:1.
Dahifar H, Faraji A, Yassobi S, Ghorbani A. Asymptomatic rickets in adolescent girls. Indian J Pediatr 2007;74(6):571-5.
Rabbani A, Alavian SM, Motlagh ME, Ashtiani MT, Ardalan G, Salavati A, Rabbani B, Rabbani A, Shams S, Parvaneh N. Vitamin D Insufficiency among Children and Adolescents Living in Tehran, Iran. J Trop Pediatr 2009;55(3):189-91.
Shakiba M, Nafei Z, Lotfi MH, Shajari A. Prevalence of vitamin D deficiency among female students in secondary guidance school in Yazd City. Acta Med Iran 2009;47(3):209-14.
Maalouf J, Nabulsi M, Vieth R, Kimball S, El-Rassi R,Mahfoud Z, El-Hajj Fuleihan G. Short- and long-termsafety of weekly high-dose vitamin D3 supplementation in school children. J Clin Endocrinol Metab2008;93(7):2693-701.
Tau C, Ciriani V, Scaiola E, Acuña M. Twice singledoses of 100,000 IU of vitamin D in winter is adequate and safe for prevention of vitamin D deficiency in healthy children from Ushuaia, Tierra Del Fuego,Argentina. J Steroid Biochem Mol Biol 2007;103(3-5):651-4.
Duhamel JF, Zeghoud F, Sempé M, Boudailliez B, Odièvre M, Laurans M, Garabédian M, Mallet E. Prevention of vitamin D deficiency in adolescents and pre-adolescents. An interventional multicenter study on the biological effect of repeated doses of 100,000 IU of vitamin D3. Arch Pediatr 2000;7(2):148-53.
Oliveri B, Cassinelli H, Mautalen C, Ayala M. Vitamin D prophylaxis in children with a single dose of 150000 IU of vitamin D. Eur J Clin Nutr 1996;50(12):807-10.
| Files | ||
| Issue | Vol 49, No 12 (2011) | |
| Section | Original Article(s) | |
| Keywords | ||
| 25-OH vitamin D Girl Dietary supplement Bolus dose | ||
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