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How Can 5-HT3 Receptor Antagonists Exert Analgesic Properties?

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Zahedi H, Maleki A, Rostami Gh. Ondansetron pretreatment reduces pain on injection of propofol. Acta Medica Iranica 2012;50(4):239-43

Färber L, Haus U, Späth M, Drechsler S. Physiology andpathophysiology of the 5-HT3 receptor. Scand J Rheumatol 2004;33:2–8.

Fiebich BL, Akundi RS, Lieb K, Candelario‐Jalil E, Gmeiner D, Haus U, Müller W, Stratz T, Muñoz E.Antiinflammatory effects of 5-HT3 receptor antagonists in lipopolysaccharide-stimulated primary human monocytes. Scand. J. Rheumatol 2004;119:28–32.

Seidel MF, Fiebich BL, Ulrich-Merzenich G, Candelario- Jalil E, Koch FW, Vetter H. Serotonin mediates PGE2 overexpression through 5-HT2A and 5-HT3 receptor subtypes in serum-free tissue culture of macrophage-like synovial cells. Rheumatol 2008;28:1017–22.

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Norouzi A, Fakhfouri G, Rahimian R. How Can 5-HT3 Receptor Antagonists Exert Analgesic Properties?. Acta Med Iran. 1;50(4):225.