Frozen Section as a Diagnostic Test for Major Salivary Gland Tumors

  • Leila V. Mostaan Cancer Research Center, Omid Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Nasrin Yazdani Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Seyed Ziaodin Madani Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran.
  • Hasty Borghei Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Shabnam Mortazavi Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Leila Ojani Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Zahra Mokhtari Mail Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Keywords:
Salivary gland tumor, Frozen section, Histopathologic diagnosis

Abstract

Major salivary gland tumors are uncommon and the exact nature of these tumors is not obvious. This study was carried out to compare the histological results of intraoperative frozen sections against those of permanent reports for major salivary glands masses. One hundred thirty-nine patients with major salivary gland masses who were candidates for surgery underwent an intraoperative frozen section biopsy. A permanent histological examination was then performed for definite diagnosis and its result was compared with that of the frozen section. Sensitivity, specificity, accuracy and the positive and negative predictive values were analyzed. The frozen section had 98.4% sensitivity, 87% specificity, 97.1% accuracy, 98.4% positive predictive value and 87% negative predictive value in differentiating between non-neoplastic and neoplastic lesions. In addition, the frozen section's identification of a mass as either benign or malignant showed 98% sensitivity, 100% specificity, 99.2% accuracy, 100% positive predictive value and 99% negative predictive value. Based on the current study's findings, it can be suggested that the frozen section is considerably accurate in the diagnosis of malignant versus benign lesions of major salivary glands, regardless of the exact histopathological type of the malignant tumors.

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How to Cite
1.
V. Mostaan L, Yazdani N, Madani SZ, Borghei H, Mortazavi S, Ojani L, Mokhtari Z. Frozen Section as a Diagnostic Test for Major Salivary Gland Tumors. Acta Med Iran. 50(7):459-462.
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