Prevalence of Vitamin D Deficiency and Rickets in Children with Cholestasis in Iran

  • Bahram Mohammadi Mail Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.
  • Mehri Najafi Department of Pediatrics, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Fateme Farahmand Department of Pediatrics, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  • Farzaneh Motamed Department of Pediatrics, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Mahsa Ghajarzadeh Student’s Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Jamshid Mohammadi Herbal Medical Research Center, School of Medicine, Yasouj University of Medical Sciences, Yasouj, Iran.
  • Mohammad Eshagh Roze Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.
Keywords:
Rickets, Vitamin D, Chronic cholestasis, Children

Abstract

This study was aimed to determine prevalence of Vitamin D deficiency and rickets in children with cholestatic liver diseases. Forty eight children with established cholestatic liver disease who referred to gastrointestinal clinic of Children Medical Center (Tehran, Iran) between April 2010 and March 2011 were enrolled in a cross-sectional study. Laboratory analysis including calcium, phosphate, albumin, total and direct bilirubin, aminotransferases, alkalinephosphatase (ALP), prothrombin time (PT), parathyroid hormone (PTH), total protein determined by routine laboratory techniques. Mean age of participants was 299.1 ± 676.8 days (range 2-3600 days) whereas twenty one were female (43.8%) and 27 (56.3%) were male. Twenty two (45.8%) had evidences of rickets in X-ray evaluation. Three children with rickets and two with normal X-ray had Vitamin D deficiency while ten in rickets group and 16 in normal group had Vitamin D insufficiency. The main underlying diseases were anatomical biliary atresia in cases with rickets and idiopathic in other group. Rickets and Vitamin D deficiency should be considered in chronic cholestatic children.

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How to Cite
1.
Mohammadi B, Najafi M, Farahmand F, Motamed F, Ghajarzadeh M, Mohammadi J, Roze ME. Prevalence of Vitamin D Deficiency and Rickets in Children with Cholestasis in Iran. Acta Med Iran. 50(7):482-485.
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