Effect of Aqueous Extract of Elaeagnus angustifolia Fruit on Experimental Cutaneous Wound Healing in Rats

  • Mahboobeh Mehrabani Natanzi Department of Biochemistry, School of Medicine, Tehran University of Medical Science, Tehran, Iran.
  • Parvin Pasalar Department of Biochemistry, School of Medicine, Tehran University of Medical Science, Tehran, Iran.
  • Mohammad Kamalinejad Depertment of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Ahmad Reza Dehpour Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Seyed Mohammad Tavangar Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Roya Sharifi Department of Biochemistry, School of Medicine, Tehran University of Medical Science, Tehran, Iran.
  • Naghmeh Ghanadian Department of Biochemistry, School of Medicine, Tehran University of Medical Science, Tehran, Iran.
  • Maryam Rahimi-Balaei Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Siavash Gerayesh-Nejad Mail Department of Biochemistry, School of Medicine, Tehran University of Medical Science, Tehran, Iran.
Keywords:
Elaeagnus Angustifolia, Histology, Hydroxyproline, Rat, Wound healing

Abstract

The present study was conducted to investigate the histological changes and wound healing effect of aqueous extract of Elaeagnus angustifolia. After creating full-thickness skin wounds on the back of 45 male Sprague-Dawley rats they were randomly divided into three groups. Treated group received the extract, positive control group were treated with mupirocin ointment 2% and control group did not receive any treatment. Wound healing rates were calculated on days 3, 5, 8, 10, 12 and 15 post-wounding and the wound tissues were harvested at 5, 10, and 15 days for histological analysis and hydroxyproline content measurement. The results indicated a significant increase in the percentage of wound contraction and hydroxyproline content in the treated group comparing to the control and positive control groups. A significant increase in the assigned histological scores was observed at 10 and 15 days in the treated and positive control groups compared to the control group. The results demonstrate that aqueous extract of Elaeagnus angustifolia accelerates cutaneous wound healing, and its effect may be due to the increased re-epithelialization and collagen deposition in wound and so it can be considered as a therapeutic agent for wound healing.

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How to Cite
1.
Mehrabani Natanzi M, Pasalar P, Kamalinejad M, Dehpour AR, Tavangar SM, Sharifi R, Ghanadian N, Rahimi-Balaei M, Gerayesh-Nejad S. Effect of Aqueous Extract of Elaeagnus angustifolia Fruit on Experimental Cutaneous Wound Healing in Rats. Acta Med Iran. 50(9):589-596.
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