The Effect of Opium Addiction on Arrhythmia Following Acute Myocardial Infarction
Abstract
The effect of opium addiction on the appearance of different types of arrhythmias after acute myocardial infarction (AMI) has been assessed in few studies. This study is aimed to determine the effect of opium on post-MI arrhythmia and also to address the differences in the appearance of different types of arrhythmias after AMI between opium addicted and non-addicted patients. In this comparative study, participants were classified into two groups with opium addiction (n=94) and without opium addiction (n=106). Post-MI arrhythmias were determined among each group. Study populations were included all patients with first AMI admitted within 6 hours of the onset of chest pain to coronary care units (CCU) of two teaching hospitals affiliated to Kerman University of Medical Sciences (KUMS) in the city of Kerman, Iran. Opium addicted subjects had significantly more frequency of arrhythmia than non-opium addicted subjects (80.9% vs. 22.6%, respectively; P<0.001). Opium addiction was a strong predictor for the occurrence of postMI arrhythmias in two models of crude analysis (crude OR=14.4, P<0.001) and after adjusting for potential confounder factors (adjusted OR = 21.9, P<0.001). The prevalence of sinus tachycardia, sinus bradycardia and atrial fibrillation in opium addicts were significantly higher than non opium addicts (P<0.05). The results of our study showed that opium addiction is a potential and strong risk for occurring post-MI arrhythmias.
Ziaaddini H, Ziaaddini MR. The household survey of drug abuse in Kerman, Iran. J Appl Sci 2005;5(2):380-2.
Karbakhsh M, Salehian Zandi N. Acute opiate overdose in Tehran: the forgotten role of opium. Addictive Behav 2007;32(9):1835-42.
Mohammadi A, Darabi M, Nasry M, Saabet-Jahromi MJ, Malek-Pour-Afshar R, Sheibani H. Effect of opium addiction on lipid profile and atherosclerosis formation in hypercholesterolemic rabbits. Exp Toxicol Pathol 2009;61(2):145-9.
Sadr Bafghi SM, Rafiei M, Bahadorzadeh L, Namayandeh SM, Soltani MH, Motafaker M, Andishmand A. Is opium addiction a risk factor for acute myocardial infarction? Acta Med Iran 2005;43(3):218-22.
Sadeghian H, Sheikhvatan M, Mahmoodian M, Sheikhfathollahi M, Hakki E, Sadeghian A, Behnam B, Haji Zeinali AM, Semnani V. Comparison of short-term clinical outcome of non-ST elevation versus ST elevation myocardial infarction. J Teh Univ Heart Ctr 2009;2:97-102.
Karam G, Reisi M, Kaseb AA, Khaksari M, Mohammadi A, Mahmoodi M. Effects of opium addiction on some serum factors in addicts with non-insulindependent diabetes mellitus. Addict Biol 2004;9(1):53-8.
Asgary S, Sarrafzadegan N, Naderi GA, Rozbehani R. Effect of opium addiction on new and traditional cardiovascular risk factors: do duration of addiction and route of administration matter? Lipids Health Dis 2008;7:42.
Das B, Daga MK, Gupta SK. Lipid pentad index: a novel= bioindex for evaluation of lipid risk factors for atherosclerosis in young adolescents and children of premature coronary artery disease patients in India. Clin Biochem 2007;40(1-2):18-24.
van den Brink OW, Delbridge LM, Rosenfeldt FL, Penny D, Esmore DS, Quick D, Kaye DM, Pepe S. Endogenous cardiac opioids: enkephalins in adaptation and protection of the heart. Heart Lung Circ 2003;12(3):178-87.
Gross ER, Hsu AK, Gross GJ. Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts. Circ Res 2004;94(7):960-6.
Marmor M, Penn A, Widmer K, Levin RI, Maslansky R. Coronary artery disease and opioid use. Am J Cardiol 2004;93(10):1295-7.
Najafi M, Sheikhvatan M, Montazeri A, Sheikh Fathollahi M. Quality of life in opium-addicted patients with coronary artery disease as measured with WHOQOLBREF. Int J Soc Psychiatr 2009;55(3):247-56.
Najafipour H, Joukar S. Combination of opium smoking and hypercholesterolemia augments susceptibility for lethal cardiac arrhythmia and atherogenesis in rabbit. Environ Toxicol Pharmacol 2012;34(2):154-159.
Pinelli A, Trivulzio S, Tomasoni L, Bertolini B, Brenna S, Bonacina E, Vignati S. Myocardial infarction noninvasively induced in rabbits by administering isoproterenol and vasopressin: protective effects exerted by verapamil. Fundam Clin Pharmacol 2004;18(6):657-67.
Feuerstein G, Siren AL. The opioid peptides. A role in hypertension? Hypertension 1987;9(6):561-5.
Hill-Pryor C, Lindsey D, Lapanowski K, Dunbar JC. The cardiovascular responses to mu opioid agonist and antagonist in conscious normal and obese rats. Peptides 2006;27(6):1520-6.
The Diagnostic and Statistical Manual of Mental Disorders, Text Revision (DSM-IV-TR). 4th ed. Washington, DC: American Psychiatric Press; 2000.
Barrett-Connor E, Giardina EG, Gitt AK, Gudat U, Steinberg HO, Tschoepe D. Women and heart disease: the role of diabetes and hyperglycemia. Arch Intern Med 2004;164(9):934-42.
Recommendations of the Second Joint Task Force of European and other Societies on coronary prevention. Prevention of coronary heart disease in clinical practice. Eur Heart J 1998;19(10):1434-503.
Bartnik M, Rydén L, Ferrari R, Malmberg K, Pyörälä K, Simoons M, Standl E, Soler-Soler J, Ohrvik J; Euro Heart Survey Investigators. The prevalence of abnormal glucose regulation in patients with coronary artery disease across Europe. The Euro Heart Survey on diabetes and the heart. Eur Heart J 2004;25(21):1880-90.
Chalmers J, MacMahon S, Mancia G, Whitworth J, Beilin L, Hansson L, Neal B, Rodgers A, Ni Mhurchu C, Clark T. 1999 World Health Organization-International Society of Hypertension Guidelines for the management of hypertension. Guidelines sub-committee of the World Health Organization. Clin Exp Hypertens 1999;21(5-6):1009-60.
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care2008;31 Suppl 1:S55-60.
Gad A, Morelli P, Decristofaro J. Perinatal isolated atrial flutter associated with maternal cocaine and opiate use in a late preterm infant. J Matern Fetal Neonatal Med 2010;23(9):1062-5.
Gorgaslidze AG, Saĭfullaeva MA, Kuz'mina MM, Golitsina LS, Smetnev AS. Cardiac arrhythmia and myocardial contraction in opium and ephedrone addiction. Kardiologiia 1993;33(1):14-6.
Kett A, Omoniyi AT, Kim H, Olariu N, Wu D, Szeto HH, Clapp JF 3rd. Baroreflex-mediated bradycardia but not tachycardia is blunted peripherally by intravenous mu-opioid agonists. Am J Obstet Gynecol 1998;178(5):950-5.
Malinowska B, Piszcz J, Koneczny B, Hryniewicz A, Schlicker E. Modulation of the cardiac autonomic transmission of pithed rats by presynaptic opioid OP4 and cannabinoid CB1 receptors. Naunyn Schmiedebergs Arch Pharmacol 2001;364(3):233-41.
Paakkari P, Paakkari L, Feuerstein G. Sirén AL. Opioidreceptor mediated regulation of heart rate in the conscious rat. Neuropharmacology 1992;31(8):777-82.
| Files | ||
| Issue | Vol 50, No 10 (2012) | |
| Section | Articles | |
| Keywords | ||
| Addiction Arrhythmia Myocardial infarction Opium | ||
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