In Vitro Susceptibility of Aflatoxigenic and Non-aflatoxigenic Aspergillus flavus Strains to Conventional Antifungal Agents

  • Azam Fattahi Department of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Iran.
  • Farideh Zaini Mail Department of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Iran.
  • Parivash Kordbacheh Department of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Iran.
  • Seyed Jamal Hashemi Department of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Iran.
  • Mahmoud Mahmoudi Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Iran.
  • Mahin Safara Department of Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Iran.
Keywords:
Antifungal agents, Aspergillus flavus, Broth microdilution, Susceptibility

Abstract

Presently appearance of resistance to antifungal agents among Aspergillus species is dramatically increasing. The objective of this study was to look at the in vitro activities of antifungal drugs against Iranian clinical (from nail, bronchoalveolar lavage, paranasal sinus) isolated A. flavus strains. The susceptibility of 45 aflatoxigenic and non-aflatoxigenic Aspergillus flavus strains were evaluated to six antifungal agents (caspofungin, itraconazole, amphotericin B, ketoconazole, fluconazole, nystatin) using CLSI M38-A2 broth microdilution method. The results indicated that 57.1%, 28.6% of aflatoxigenic and 25.8%, 6.5% of non-aflatoxigenic isolates were susceptible to caspofungin, amphotericin B respectively. All isolates but one aflatoxigenic strain were sensitive to ketoconazole. All 45 strains showed to be resistant to nystatin. Also 64.28%, 92.9% of aflatoxigenic and 64.51%, 100% of non-aflatoxigenic isolates were resistant to fluconazole and itraconazole in ranking order. There was no statistically significant difference between the susceptibilities of aflatoxigenic and non-aflatoxigenic strains of A. flavus to tested antifungal agents.

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How to Cite
1.
Fattahi A, Zaini F, Kordbacheh P, Hashemi SJ, Mahmoudi M, Safara M. In Vitro Susceptibility of Aflatoxigenic and Non-aflatoxigenic Aspergillus flavus Strains to Conventional Antifungal Agents. Acta Med Iran. 50(12):798-804.
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