The Prevalence of Iodine Deficiency Disorder in Two Different Populations in Northern Province of Iran: A Comparison Using Different Indicators Recommended by WHO
-
Setilla Dalili
,
Zahra Mohtasham-Amiri
,
Seyed Mahmood Rezvani
,
Arsalan Dadashi
,
Abdolreza Medghalchi
,
Simin Hoseini
,
Hajar Gholami-Nezhad
,
Anis Amirhaki
Abstract
Comparison of the prevalence of Iodine Deficiency Disorder (IDD) in neonates and school children using two different WHO indicators. From 2006 to 2010, 119701 newborns were screened by measurement of serum TSH level by heel prick. Neonates who had blood TSH ≥ 5 mIU/l were recalled for more evaluation. In the same period of time, urine iodine was measured in 1200 school-aged children. The severity of IDD was classified using WHO, UNICEF, ICCIDD criteria. Between 2006 and 2010 a total of 138832 neonates were screened in Guilan province and the total recall rate (neonates with TSH level ≥ 5 mIU/l) was 1.8 %. The incidence rate of Congenital Hypothyroidism (CH) was 1/625. The median urine iodine level in school-aged children was 200-299 μg/l. Considering the WHO, UNICEF, ICCIDD criteria, Guilan province would be classified as a none-IDD endemic area. However, health care systems should pay attention to the iodine excess and the risk of iodine induced hyperthyroidism in this population.
Verheesen RH, Schweitzer CM. Iodine deficiency, more than cretinism and goiter. Med Hypotheses 2008; 71(5):645-8.
Zimmermann MB. Iodine deficiency. Endocr Rev 2009; 30(4):376-408.
Zimmermann MB. Iodine deficiency in pregnancy and the effects of maternal iodine supplementation on the offspring: a review. Am J Clin Nutr 2009; 89(2):668S-72.
Vitti P, Delange F, Pinchera A, Zimmermann MB, Dunn JT. Europe is iodine deficient. Lancet 2003;361(9364):1226.
World Health Organization/United Nations Children’s Fund/International Council for the Control of Iodine Deficiency Disorders; Assessment of Iodine Deficiency Disorders and Monitoring their Elimination. WHO/NHD/2001/01.1, pp. 1–107. WHO, Geneva, Switzerland.
Zimmermann MB. Methods to assess iron and iodine status. British Journal of Nutrition 2008;99( Suppl 3):S2-9.
Ristic-Medic D, Piskackova Z, Hooper L, Ruprich J, Casgrain A, Ashton K, Pavlovic M, Glibetic M. Methods of assessment of iodine status in humans: a systematic review. Am J Clin Nutr 2009;89(6):2052S–69.
Michael B. Zimmermann. Assessing Iodine Status and Monitoring Progress of Iodized Salt Programs. J. Nutr. 2004;134(7): 1673–7.
Li M, Eastman CJ. Neonatal TSH screening: is it a sensitive and reliable tool for monitoring iodine status in populations? Best Pract Res Clin Endocrinol Metab 2010;24(1):63–75.
Missler U, Gutekunst R, Wood WG. Thyroglobulin is a more sensitive indicator of iodine deficiency than thyrotropin: development and evaluation of dry blood spot assays for thyrotropin and thyroglobulin in iodine-deficient geographical areas. Eur J Clin Chem Clin Biochem 1994;32(3):137-43.
Loeber JG. Neonatal screening in Europe; the situation in 2004. J Inherit Metab Dis 2007;30(4):430-8.
Panamonta O, Tuksapun S, Kiatchoosakun P, Jirapradittha J, Kirdpon W, Loapaiboon M. Newborn screening for congenital hypothyroidism in Khon Kaen University Hospital, the first three years, a preliminary report. J Med Assoc Thai 2003;86(10):932-7.
Daher R, Beaini M, Mahfouz R, Cortas N, Younis KA. A neonatal screening in Lebanon: Results of five years' experience. Ann Saudi Med 2003;23(1-2):16-9.
Hashemipour M, Hovsepian S, Kelishadi R, Iranpour R, Hadian R, Haghighi S, Gharapetian A, Talaei M, Amini M. Permanent and transient congenital hypothyroidism in Isfahan-Iran. J Med Screen 2009;16(1):11-6.
Karamizadeh Z, Dalili S, Sanei-far H, Karamifard H, Amirhakimi GH, Mohammadi H. Does Congenital Hypothyroidism Have Different Etiologies in Iran? Iran J Pediatr 2011;21(2):188-92.
Copeland DL, Sullivan KM, Houston R, May W, Mendoza I, Salamatullah Q, Solomons N, Nordenberg D, Maberly GF. Comparison of neonatal thyroid-stimulating hormone levels and indicators of iodine deficiency in school children Public Health Nutrition 2002;5(1):81-7.
Delange F, de Benoist B, Alnwick D. Risks of iodineinduced hyperthyroidism after correction of iodine deficiency disorders by iodized salt. Thyroid 1999;9(6):545-56.
| Files | ||
| Issue | Vol 50, No 12 (2012) | |
| Section | Articles | |
| Keywords | ||
| Iodine deficiency disorder (IDD) Neonatal TSH Urine iodine WHO criteria | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
