Cutaneous Leiomyoma: Novel Histologic Findings for Classification and Diagnosis
Smooth muscle tumors rather benign or malignant can arise wherever the muscular tissue presents but cutaneous leiomyoma is one of the rare benign tumors of the which even the diagnostic criteria from the malignant type of the tumor is still in doubt. This study was aimed to compare the subtypes of cutaneous leiomyoma from different histologic aspects in order to find unique criteria for better classification and diagnosis. The six year data base of our center was reviewed and 25 patients with cutaneous leiomyoma were included in this study. Of 25 patients, 5 were female and 20 were male. 5 patients had angioleiomyoma (ALM) and 20 had pilar leiomyoma (PLM). ALM had following characteristics: dilated vascular canals intermingled with compact smooth muscle bundles; well circumscribe counter and myxoid and hyaline changes through the tumor. In contrast, PLMs had following histologic features: poor defined outline, entrapped hair follicles and eccrine glands, acanthosis and elongated rete ridges with hyperpigmentation and smooth muscle bundles which are interdigitated with elongated rete ridges. Here we introduced some distinct histological features for each subtype of the cutaneous leiomyoma which can lead to create novel criteria for classification and diagnosis of the lesion.
Usmani N, Merchant W, Yung A. A case of cutaneous symplastic leiomyoma – a rare variant of cutaneous pilar leiomyoma. J Cutan Pathol 2008;5(3):329-31.
Mitra A, Gudgeon PW, Merchant W, Shah M. A case of diffuse pilar leiomyoma or acquired smooth muscle hamartoma? Clin Exp Dermatol 2009;34(5):145-7.
Matthews JH, Pichardo RO, Hitchcock MG, Leshin B. Cutaneous Leiomyoma with Cytologic Atypia, Akin to Uterine Symplastic Leiomyoma. Dermatol Surg 2004;30(9):1249–51.
Kawagishi N, Kashiwagi T, Ibe M, Manabe A, Ishida- Yamamoto A, Hashimoto Y, Iizuka H. Pleomorphic angioleiomyoma: report of two cases with immunohistochemical studies, Am J Dermatopathol 2000;22(3):268–71.
Kacerovska D, Michal M, Kreuzberg B, Mukensnabl P, Kazakov DV. Acral calcified vascular leiomyoma of the skin: A rare clinicopathological variant of cutaneous vascular leiomyomas. J Am Acad Dermatol 2008;59(6):1000-4.
Ramesh P, Annapureddy SR, Khan F, Sutaria PD. Angioleiomyoma: a clinical, pathological and radiological review. Int J Clin Pract 2004;58(6):587–91.
Ku J, Campbell C, and Bennett I. Leiomyoma of the Nipple. The Breast Journal 2006;12(4):377–80.
Alam NA, Barclay E, Rowan AJ, Tyrer JP, Calonje E, Manek S, Kelsell D, Leigh I, Olpin S, Tomlinson IP. Clinical Features of Multiple Cutaneous and Uterine Leiomyomatosis. Arch Dermatol 2005;141(2):199-206.
Makino E, Yamada J, Tada J, Arata J, Iwatsuki K. Cutaneous angiolipoleiomyoma. J Am Acad Dermatol 2006; 54(1):167-71.
Utikal J, Haus G, Poenitz N, Koenen W, Back W, Dippel E, Gratchev A, Goerdt S. Cutaneous leiomyosarcoma with myxoid alteration arising in a setting of multiple cutaneous smooth muscle neoplasms . J Cutan Pathol 2006;33(Suppl2):20-3.
Holst VA, Junkins-Hopkins JM, and Elenitsas R. Cutaneous smooth muscle neoplasms: Clinical features, histologic findings, and treatment options. J Am Acad Dermatol 2002;46(4):477-90.
Huang K.C and Lee K.F. Angioleiomyoma in the palm of an 11-year-old boy. Skeletal Radiol 2008;37(4):339-41.
Freedman AM, Meland NB. Angioleiomyomas of the extremities: report of a case and review of the Mayo clinic experience. Plast Reconstr Surg 1989;83(2):328-31.
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