Lamotrigine Effects on Breastfed Infants

  • Hosein Dalili Department of Neonatology, Breast Feeding Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Fatemeh Nayeri Department of Neonatology, Breast Feeding Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Mamak Shariat Department of Maternal and Child Health, Maternal-Fetal-Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Leila Asgarzadeh Mail Department of Medicine, Breast Feeding Research Center, Tehran University of Medical Sciences, Tehran, Iran
Lamotrigine, Effect, Breastfed Infants


Lamotrigine is a safe anti-epileptic drug among pregnant and lactating women. Some concerns exist regarding the safety of lamotrigine during breastfeeding and related neonatal complications. In this brief review, this matter was evaluated and discussed. In this review study, the medical literature available in search databases such as Embase, Scopus, PubMed, and Medline and even also local medical search engines were evaluated. The results indicated that lamotrigine is a safe anti-epileptic drug for breastfeeding women with rare and usually mild adverse effects among neonates exposed to high milk concentration of this drug and its metabolites. However, close periodical monitoring for infants whose mothers are utilizing lamotrigine is recommended to decrease the probability of severe side effects among them.


Pennell PB. Antiepileptic drug pharmacokinetics during pregnancy and lactation. Neurology 2003;61(6 Suppl 2):S35-42.

Sabers A, Tomson T. Managing antiepileptic drugs during pregnancy and lactation. Curr Opin Neurol 2009;22(2):157-61.

Adab N. Therapeutic monitoring of antiepileptic drugs during pregnancy and in the postpartum period: is it useful? CNS Drugs 2006;20(10):791-800.

Ohman I, Vitols S, Tomson T. Lamotrigine in pregnancy: pharmacokinetics during delivery, in the neonate, and during lactation. Epilepsia 2000;41(6):709-13.

Tomson T, Ohman I, Vitols S. Lamotrigine in pregnancy and lactation: a case report. Epilepsia 1997;38(9):1039-41.

Madadi P, Ito S. Perinatal exposure to maternal lamotrigine: clinical considerations for the mother and child. Can Fam Physician 2010;56(11):1132-4.

Wakil L, Epperson CN, Gonzalez J, et al. Neonatal outcomes with the use of lamotrigine for bipolar disorder in pregnancy and breastfeeding: a case series and review of the literature. Psychopharmacol Bull 2009;42(3):91-8.

Liporace J, Kao A, D'Abreu A. Concerns regarding lamotrigine and breast-feeding. Pediatrics 2008;122(1):e223-31.

Newport DJ, Pennell PB, Calamaras MR, et al. Lamotrigine in breast milk and nursing infants: determination of exposure. Pediatrics 2008;122(1):e223-31.

Nordmo E, Aronsen L, Wasland K, et al. Severe apnea in an infant exposed to lamotrigine in breast milk. Ann Pharmacother 2009;43(11):1893-7.

Wyszomirska E, CzerwiƄska K. Identification and assay of lamotrigine in human milk with gas chromatography and densitometry. Acta Pol Pharm 1999;56(2):101-5.

Rambeck B, Kurlemann G, Stodieck SR, et al. Concentrations of lamotrigine in a mother on lamotriginentreatment and her newborn child. Epilepsy Res 2009;85(1):60-4.

Page-Sharp M, Kristensen JH, Hackett LP, et al. Transfer of lamotrigine into breast milk. Ann Pharmacother 2006;40(7-8):1470-1.

Fotopoulou C, Kretz R, Bauer S, et al. Prospectively assessed changes in lamotrigine-concentration in women with epilepsy during pregnancy, lactation and the neonatal period. Epilepsy Res 2009;85(1):60-4.

How to Cite
Dalili H, Nayeri F, Shariat M, Asgarzadeh L. Lamotrigine Effects on Breastfed Infants. Acta Med Iran. 53(7):393-394.
Review Article(s)