Evaluation of Chronic Physical and Psychological Stress Induction on Cardiac Ischemia / Reperfusion Injuries in Isolated Male Rat Heart: The Role of Sympathetic Nervous System
Exposure to stress leads to physiological changes called “stress response” which are the result of the changes in the adrenomedullary hormone system, hypothalamus-pituitary-adrenal (HPA) and sympathetic nervous system (SNS) activity. In the present study, the effects of chronic physical and psychological stress and also the role of sympathetic system effects in stress on ischemia/reperfusion (I/R) injuries have been= studied in isolated rat heart. Rat heart was isolated and subjected to 30 min regional ischemia and 120 min reperfusion. The daily stress was induced for one week prior to I/R induction. Sympathectomy was done chemically by injection of hydroxyl-dopamine prior to stress induction. There were no significant changes in heart rate and Coronary Flow between groups. Left ventricular developed pressure (LVDP) and rate product pressure (RPP) in both physical and psychological stress groups decreased significantly compared to those in control group (P<0.05), but there was no significant difference betwe n physical and psychological stress groups. Infarct size significantly increased in both physical and psychological stress groups and control group (P<0.05. Sympathectomy before induction of stress led to the elimination of the deleterious effects of stress as compared with stress groups (P<0.05). These results show that induction of chronic physical and psychological stress prior to ischemia/reperfusion causes enhancement of myocardial injuries and it seems that increased sympathetic activity in response to stress is responsible for these adverse effects of stress on ischemic/reperfused heart.
Tennant C, Langeluddecke P, Byrne D. The concept of stress. Aust N Z J Psychiatry 1985;19(2):113-8.
Silva SM, Madeira MD. Effects of chronic alcohol consumption and withdrawal on the response of the male and female hypothalamic-pituitary-adrenal axis to acute immune stress. Brain Res 2012;1444:27-37.
Seyler LE. The antihistaminic drugs; their relationship as shown by the structural formulas. Ann Allergy 1950; 8(3):322-7.
Seyler W. Tuberculosis following gunshot wound; contribution to the problem of traumatic tuberculosis. Beitr Klin Tuberk Spezif Tuberkuloseforsch 1950, 104(2):140-50.
Carrasco GA, Van de Kar LD. Neuroendocrine pharmacology of stress. Eur J Pharmacol 2003;463(1-3):235-72.
Johnson EO, Kamilaris TC, Chrousos GP, et al. Mechanisms of stress: a dynamic overview of hormonal and behavioral homeostasis. Neurosci Biobehav Rev 1992;16(2):115-30.
Tsigos C, Chrousos GP. Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosom Res 2002;53(4):865-71.
Angelucci L. The glucocorticoid hormone: from pedestal to dust and back. Eur J Pharmacol 2000;405(1-3):139-47.
Korte SM. Corticosteroids in relation to fear, anxiety and psychopathology. Neurosci Biobehav Rev 2001;25(2):117-42.
Fromm L, Heath DL, Vink R, et al. Magnesium attenuates post-traumatic depression/anxiety following diffuse traumatic brain injury in rats. J Am Coll Nutr 2004;23(5):529S-3S.
Liu X, Peprah D, Gershenfeld HK. Tail-suspension induced hyperthermia: a new measure of stress reactivity. J Psychiatr Res 2003;37(3):249-59.
Zebrowska-Lupina I, Ossowska G, Lupina T, Klenk- Majewska B. Prolonged treatment with beta-adrenoceptor antagonists counteracts the aggression deficit induced by chronic stress. Pol J Pharmacol 1997;49(5):283-9.
Lambert EA, Lambert GW. Stress and its role in sympathetic nervous system activation in hypertension and the metabolic syndrome. Curr Hypertens Rep 2011;13(3):244-8.
Brydon L, Steptoe A. Stress-induced increases in interleukin-6 and fibrinogen predict ambulatory blood pressure at 3-year follow-up. J Hypertens 2005;23(5):1001-7.
Yan LL, Liu K, Matthews KA, et al. Psychosocial factors and risk of hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) study. JAMA 2003;290(16):2138-48.
Lampert R, Jain D, Burg MM, et al. Destabilizing effects of mental stress on ventricular arrhythmias in patients with implantable cardioverter-defibrillators. Circulation 2000;101(2):158-64.
Rosales VP, Ikeda K, Hizaki K, et al. Emotional stress and brux-like activity of the masseter muscle in rats. Eur J Orthod 2002;24(1):107-17.
Martinelli PM, Camargos ER, Morel G, et al. Rat heart GDNF: effect of chemical sympathectomy. Histochem Cell Biol 2002;118(4):337-43.
Naderi R, Imani A, Faghihi M. Phenylephrine produces late pharmacological preconditioning in the isolated rat heart. Eur J Pharmacol 2010;627(1-3):203-8.
Imani A, Faghihi M, Keshavarz M, et al. Effect of different doses of noradrenaline against ischemia-induced ventricular arrhythmias in rat heart in vivo. Indian Pacing Electrophysiol J 2009;9(1):35-44.
Clark DW. Effects of immunosympathectomy on development of high blood pressure in genetically hypertensive rats. Circ Res 1971;28(3):330-6.
Lucini D, Di Fede G, Parati G, et al. Impact of chronic psychosocial stress on autonomic cardiovascular regulation in otherwise healthy subjects. Hypertension 2005;46(5):1201-6.
Wu S, Wong MC, Chen M, et al. Role of opioid receptors in cardioprotection of cold-restraint stress and morphine. J= Biomed Sci 2004;11(6):726-31.
Moghimian M, Faghihi M, Karimian SM, et al. The effect of acute stress exposure on ischemia and reperfusion injury in rat heart: role of oxytocin. Stress 2012;15(4):385-92.
Brotman DJ, Girod JP, Posch A, et al. Effects of short-term glucocorticoids on hemostatic factors in healthy volunteers. Thromb Res 2006;118(2):247-52.
von Kanel R, Dimsdale JE. Effects of sympathetic activation by adrenergic infusions on hemostasis in vivo. Eur J Haematol 2000;65(6):357-69.
Zgraggen L, Fischer JE, Mischler K, et al. Relationship between hemoconcentration and blood coagulation responses to acute mental stress. Thromb Res 2005; 115(3):175-83.
Bacon SL, Ring C, Hee FL, et al. Hemodynamic, hemostatic, and endothelial reactions to psychological and physical stress in coronary artery disease patients. Biol Psychol 2006;71(2):162-70.
Reims HM, Sevre K, Hoieggen A, et al. Blood viscosity: effects of mental stress and relations to autonomic nervous system function and insulin sensitivity. Blood Press 2005;14(3):159-69.
Baxter GF, Goodwin RW, Wright MJ, et al. Myocardial protection after monophosphoryl lipid A: studies of delayed anti-ischaemic properties in rabbit heart. Br J Pharmacol 1996; 117(8):1685-92.
Endo Y, Yamauchi K, Fueta Y, et al. Changes of body temperature and plasma corticosterone level in rats during psychological stress induced by the communication box. Med Sci Monit 2001;7(6):1161-5.
Adams V, Doring C, Schuler G. Impact of physical exercise on alterations in the skeletal muscle in patients with chronic heart failure. Front Biosci 2008;13:302-11.
Abraham J, Mudd JO, Kapur NK, et al. Stress cardiomyopathy after intravenous administration of catecholamines and beta-receptor agonists. J Am Coll Cardiol 2009;53(15):1320-5.