Unstimulated Salivary p53 in Patients with Oral Lichen Planus and Squamous Cell Carcinoma
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Abstract
Unstimulated whole salivary p53 was evaluated in non-involved subjects, in patients suffering from oral lichen planus (OLP) and squamous cell carcinoma (SCC). A total of 34 patients with OLP, 24 patients suffering from oral SCC and 41 non-involved participants were enrolled. The unstimulated whole saliva p53 level was assayed by ELISA. Data was analyzed by ANOVA followed by the Tukey post hoc test. Saliva p53 concentration in patients with SCC (5.36±1.08) was significantly higher than in healthy participants (0.41±0.04) and in patients suffering from OLP (0.94±0.31). This study could not confirm the precancerous nature of OLP based on the relatively low p53 expressions in comparison to SCC.
Acay RR, Felizzola CR, de Araújo N, et al. Evaluation of proliferative potential in oral lichen planus and oral lichenoid lesions using the immunohistochemical expression of p53 and Ki67. Oral Oncol 2006;42(5):475-80.
Agha-Hosseini F, Mirzaii-Dizgah I, Mikaili S, et al. Increased salivary lipid peroxidation in human subjects with oral lichen planus. Int J Dent Hyg 2009;7(4):246-50.
Agha-Hosseini F, Khalili M, Rohani B. Immunohistochemistry analysis of p53 and ki-67 proteins in oral lichen Planus and normal oral mocusa. Iranian J Publ Health 2009;38(2):37-43.
Agha-Hosseini F, Borhan-Mojabi K, Monsef-Esfahani HR, et al. Efficacy of purslane in the treatment of oral lichen planus. Phytother Res 2010;24(2):240-4.
Ebrahimi M, Boldrup L, Coates PJ, et al. Expression of novel p53 isoforms in oral lichen planus. Oral Oncol 2008;44(2):156-61.
Valente G, Pagano M, Carrozzo M, et al. Sequential immunohistochemical p53 expression in biopsies of oral lichen planus undergoing malignant evolution. J Oral Pathol Med 2001;30(3):135-40.
Ogmundsdóttir HM, Hilmarsdóttir H, Astvaldsdóttir A, et al. Oral lichen planus has a high rate of TP53 mutations. A study of oral mucosa in Iceland. Eur J Oral Sci2002;110(3):192-8.
Hassan NM, Tada M, Hamada J, et al. Presence of dominant negative mutation of TP53 is a risk of early recurrence of oral cancer. Cancer Lett 2008;270(1):108-19.
Snyder LA, Bertone ER, Jakowski RM, et al. p53 expression and environmental tobacco smoke exposure in feline oral squamous cell carcinoma. Vet Pathol 2004;41(3):209-14.
Bermejo-Fenoll A, Sanchez-Siles M, López-Jornet P, et al. Premalignant nature of oral lichen planus. A retrospective study of 550 oral lichen planus patients from south-eastern Spain. Oral Oncol 2009;45(8):e54-6.
Lee JJ, Kuo MY, Cheng SJ, et al. Higher expressions of p53 and proliferating cell nuclear antigen (PCNA) in atrophic oral lichen planus and patients with areca quid chewing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;99(4):471-8.
Mashayekhi F, Aghahoseini F, Rezaie A, et al. Alteration of cyclic nucleotides levels and oxidative stress in saliva of human subjects with periodontitis. J Contemp Dent Pract 2005;6(4):46-53.
Agha-Hosseini F, Mirzaii-Dizgah I, Moghaddam PP, et al. Stimulated whole salivary flow rate and composition in menopausal women with oral dryness feeling. Oral Dis 2007;13(3):320-3.
Agha-Hosseini F, Dizgah IM, Amirkhani S. The composition of unstimulated whole saliva of healthy dental students. J Contemp Dent Pract 2006;7(2):104-11.
Agha-Hosseini F, Mirzaii-Dizgah I, Rahimi A, et al. Correlation of serum and salivary CA125 levels in patients with breast cancer. J Contemp Dent Pract 2009;10(6):E001-8.
Agha-Hosseini F, Mirzaii-Dizgah I, Rahimi A. Correlationmof serum and salivary CA15-10(6):E001-8.3 levels in patients with breast cancer. Med Oral Patol Oral Cir Bucal 2009;14(10):e521-4.
Fan GK, Chen J, Ping F, Geng Y. Immunohistochemical analysis of P57(kip2), p53 and hsp60 expressions in premalignant and malignant oral tissues. Oral Oncol 2006;42(2):147-53.
Yoneda K, Yokoyama T, Yamamoto T, et al. p53 gene mutations and p21 protein expression induced independently of p53, by TGF-beta and gamma-rays in squamous cell carcinoma cells. Eur J Cancer 1999;35(2):278-83.
Guo-Kang F, Jun C, Feiyun P, et al. Immunohistochemical analysis of P57 (kip 2), p53 and hsp60 expressions in premalignant and malignant oral tissues. Oral Oncology (2006);42(2):147-153
Kaur J, Srivastava A, Ralhan R. Prognostic significance of p53 protein overexpression in betel- and tobacco-related oral oncogenesis. Int J Cancer 1998;79(4):370-5.
Schoelch ML, Regezi JA, Dekker NP, et al. Cell cycle proteins and the development of oral squamous cell carcinoma. Oral Oncol 1999;35(3):333-42.
Kuropkat C, Venkatesan TK, Caldarelli DD, et al. Abnormalities of molecular regulators of proliferation and apoptosis in carcinoma of the oral cavity and oropharynx. Auris Nasus Larynx 2002;29(2):165-74.
Montebugnoli L, Farnedi A, Marchetti C, et al. High proliferative activity and chromosomal instability in oral lichen planus. Int J Oral Maxillofac Surg 2006;35(12):1140-4.
Rad M, Hashemipoor MA, Mojtahedi A, et al. Correlation between clinical and histopathologic diagnoses of oral lichen planus based on modified WHO diagnostic criteria. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107(6):796-800.
Scully C, Beyli M, Ferreiro MC, et al. Update on oral lichen planus: etiopathogenesis and management. Crit Rev Oral Biol Med 1998;9(1):86-122.
González-Moles MA, Bascones-Ilundain C, Gil Montoya JA, et al. Cell cycle regulating mechanisms in oral lichen planus: molecular bases in epithelium predisposed to malignant transformation. Arch Oral Biol 2009;51(12):1093-103.
Lee JJ, Kuo MY, Cheng SJ, et al. Higher expressions of p53 and proliferating cell nuclear antigen (PCNA) in atrophic oral lichen planus and patients with areca quidchewing. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;99(4):471-8.
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| Issue | Vol 53, No 7 (2015) | |
| Section | Original Articles | |
| Keywords | ||
| Oral lichen planus Saliva SCC p53 | ||
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