UDP-Glucuronosyltransferase Promoter Polymorphism in Iranian Neonates with Idiopathic Hyperbilirubinemia

  • Mahbod Kaveh Mail Department of Neonatology, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Tahereh Esmailnia Department of Neonatology, Vali-e-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Fatemeh Nayeri Department of Neonatology, Vali-e-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Firoozeh Nili Department of Neonatology, Vali-e-Asr Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Fatemeh Davari Tanha Department of Obstetrics &Gynecology , Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Mahsa Ghajarzdeh Brain and Spinal Injury Repair Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Keywords:
Idiopathic, Hyperbilirubinemia, Neonate, UDP-glucuronosyltransferase gene

Abstract

To determine the association between polymorphism of UGT1A1 gene and idiopathic hyperbilirubinemia in Iranian neonates. Fifty neonates with idiopathic hyperbilirubinemia and Serum total bilirubin (STB) more that 15mg/dl and 50 neonates with idiopathic hyperbilirubinemia and Serum total bilirubin (STB) less than 15mg/dl enrolled in this study. Thymine-adenine (TA)  repeats in the promoter region of UGT1A1 gene investigated by means of  polymerase- chain reaction (PCR) DNA sequencing. Demographic characteristics did not differ significantly between groups while STB was higher in case group (17.5±1.9 vs. 10.4±1.8, p value<0.001). Among one hundred neonates evaluated in this study, TA6/6, TA6/7 and TA7/7 genotypes found in 52%, 42% and 6%, totally. TA6/7 and TA7/7 genotypes observed in case group more than the control group (P<0.001). STB levels were significantly higher in cases with TA6/7 and TA7/7 genotype pattern (P<0.001). Heterozygous and variant homozygous genotypes of the promoter region of UGT1A1 gene in healthy Iranian neonates with idiopathic hyperbilirubinemia should be considered.

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How to Cite
1.
Kaveh M, Esmailnia T, Nayeri F, Nili F, Davari Tanha F, Ghajarzdeh M. UDP-Glucuronosyltransferase Promoter Polymorphism in Iranian Neonates with Idiopathic Hyperbilirubinemia. Acta Med Iran. 51(11):789-792.
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