Clinical Features of Laryngeal Tuberculosis in Iran
Tuberculosis is a major health problem in Iran and its laryngeal involvement is not uncommon. Laryngeal tuberculosis is so infectious and delay in diagnosis and treatment could result spread of disease and causes divesting complications. We reviewed clinical and para-clinical characteristics of patients with laryngeal tuberculosis in Iran. In a cross sectional study, patients with laryngeal tuberculosis were studied and followed. All patients admitted from May 2000 to Dec 2011 in Amir-Alam hospital, a referral center for laryngeal diseases in Tehran. We studied 19 cases of laryngeal tuberculosis with typical histopathology (chronic granulomatous inflammation with caseous necrosis and langhans-type giant cells) and 6 cases of laryngeal tuberculosis with atypical histopathology (chronic granulomatous inflammation or chronic inflammation without necrosis). They had laryngeal symptoms and signs from 2 to 12 months before definitive diagnosis. Macroscopic appearances of laryngeal lesions were exophytic in 11 cases and ulcerative in 14 cases. True vocal cords were involved in 22 cases. The primary clinical diagnosis was malignancy in 17 cases, tuberculosis in 5 cases, and nonspecific inflammation in 3 cases. The chest x-ray findings were compatible with tuberculosis in 14 patients. The response to anti-tuberculosis therapy was desirable in all patients. In endemic area, tuberculosis should be considered as an important diagnosis in patients with laryngeal lesions even when histopathology of laryngeal lesions is not typical. Association with pulmonary tuberculosis helps for diagnosis.
Prasad KC, Sreedharan S, Chakravarthy Y, Prasad SC. Tuberculosis of the head and neck: experience in India. J Laryngol Otol 2007;121(10):979-85.
Rizzo PB, Da Mosto MC, Clari M, Scotton PG, Vaglia A, Marchiori C. Laryngeal tuberculosis: an often forgotten diagnosis. Int J Infect Dis 2003;7(2):129–31.
Menon K, Bem C, Gouldesbrough D, Strachan DR. A clinical review of 128 cases of head and neck tuberculosis presenting over a 10-year period in Bradford, UK. J Laryngol Otol 2007;121(4):362-8.
Caldarelli DD, Friedberg SA, Harris AA. Medical andsurgical aspects of the granulomatous diseases of the larynx. Otolaryngol Clin North Am 1979;12(4):767–81.
Shin JE, Nam SY, Yoo SJ, Kim SY. Changing trends in clinical manifestations of laryngeal tuberculosis. Laryngoscope. 2000 Nov; 110(11):1950-3.
Wang CC, Lin CC, Wang CP, Liu SA, Jiang RS. Laryngeal tuberculosis: a review of 26 cases. Otolaryngol Head Neck Surg 2007;137(4):582-8.
Nalini B, Vinayak S. Tuberculosis in ear, nose, and throat practice: its presentation and diagnosis. Am J Otolaryngol 2006;27(1):39-45.
Lim JY, Kim KM, Choi EC, Kim YH, Kim HS, Choi HS. Current clinical propensity of laryngeal tuberculosis: review of 60 cases. Eur Arch Otorhinolaryngol 2006;263(9):838-42.
Nishiike S, Irifune M, Doi K, Sawada T, Kubo T. Laryngeal tuberculosis: a report of 15 cases. Ann Otol Rhinol Laryngol 2002;111(10):916-8.
Uslu C, Oysu C, Uklumen B. Tuberculosis of the epiglottis: a case report. Eur Arch Otorhinolaryngol 2008;265(5):599-601.
Obstructing mass lesion of epiglottis: it can be tubercular. Indian J Tuberc 2008;55(2):100-3.
Thaller SR, Gross JR, Pilch BZ, Goodman ML. Laryngeal tuberculosis as manifested in the decades 1963–1983. Laryngoscope 1987;97(7 Pt 1): 848–850.
Kandiloros DC, Nikolopoulos TP, Ferekidis EA, Tsangaroulakis A, Yiotakis JE, Davilis D, Adamopoulos GK. Laryngeal tuberculosis at the end of the 20th century. J Laryngol Otol 1997;111(7):619-21.
Polok A, Namysłowski G, Scierski W, Czecior E, Mrówka-Kata K, Gac B. Tuberculosis within laryngologic organs. Pol Merkur Lekarski 2005;19(111): 473-4.
El Kettani NE, El Hassani M, Chakir N, Jiddane M. Primary laryngeal tuberculosis mimicking laryngeal carcinoma: CT scan features. Indian J Radiol Imaging 2010;20(1):11-2.
Suhail A, Ahmed MS, Sobani ZU, Ghaffar S. Laryngeal tuberculosis presenting as laryngeal carcinoma. J Pak Med Assoc 2012;62(2):167-8.
Yencha MW, Linfesty R, Blackmon A. Laryngeal tuberculosis. Am J Otolaryngol 2000;21(2):122-6.
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