5-HT3 Receptor Antagonists: New Promising Therapeutic Agents in Diabetes and Its Complications

  • Reza Rahimian Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Brain and Spinal Injury Repair Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Shahram Ejtemaei Mehr Mail Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Gohar Fakhfouri Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Ahmad Reza Dehpour Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Brain and Spinal Injury Repair Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Keywords:
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Abstract

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References

Carvalho F, Marcedo D, Banderia I, Maldonado I, Salles L, Azevedo MF, Rocha MA Jr, Fregoneze JB, De Castroe- Silva E. Central 5-HT3 receptor stimulation by m-CPBG increases blood glucose in rats. Horm Metabol Res 2002;34:55–61.

Heimes K, Feistel B, Verspohl EJ. Impact of the 5-HT3 receptor channel system for insulin secretion and interaction of ginger extracts. Eur J of Pharmacol 2009;624:58–65.

Fakhfouri G, Rahimian R, Ghia JE, Khan WI, Dehpour AR. Impact of 5-HT3 receptor antagonists on peripheral and central diseases. Drug Discov Today 2012;17(13-14):741-7.

Rahimian R, Dehpour AR, Fakhfouri G, Khorramizadehc MR,, Ghiad JE, Seyedabadia M, Caldarellie A, Mousavizadehf K, Forouzandehg M, Ejtemaei Mehr Sh. Tropisetron Upregulates Cannabinoid CB1 Receptors in Cerebellar Granule Cells: Possible Involvement of Calcineurin. Brain Res 2011;1417:1–8.

Norouzi A, Fakhfouri G, Rahimian R. How Can 5-HT3 Receptor Antagonists Exert Analgesic Properties? Acta Med Iran 2012;50(4):225.

Eisensamer B, Rammes G, Gimpl G, Shapa M, Ferrari U, Hapfelmeier G, Bondy B, Parsons C, Gilling K, Zieglgänsberger W, Holsboer F, Rupprecht R. Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor. Molecul Psychiatry 2003;8:994–1007.

How to Cite
1.
Rahimian R, Ejtemaei Mehr S, Fakhfouri G, Dehpour AR. 5-HT3 Receptor Antagonists: New Promising Therapeutic Agents in Diabetes and Its Complications. Acta Med Iran. 51(10):736.
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