Evaluation of Low Level Laser Therapy in Reducing Diabetic Polyneuropathy Related Pain and Sensorimotor Disorders
Over the past three decades physicians have used light level laser therapy (LLLT) for the management and the treatment of diabetic peripheral neuropathy and have obtained results that calls for further investigations. This study aimed to investigate the effectiveness of LLLT in treatment of pain symptoms in patients with diabetic polyneuropathy. In this study 60 patients with diabetic peripheral neuropathy were matched based on their sex, age, BMI, type of diabetes, duration of diabetes, and duration of pain, and randomized to case and control groups based on their established scores on the visual analog scale (VAS) and the Toronto clinical scoring system (TCSS). Cases received laser therapy with wavelength of 78 nm and 2.5 j/cm2 two times a week, each time for 5 min, for one month. During the same period, controls received sham laser therapy. Comparing the differences between the two groups' VAS and TCSS mean scores before the intervention with that of the 2 weeks and 4 weeks after the intervention we were able to see a statistically significant difference between the two groups (P<0.05). On the other hand, when we compared their VAS and TCSS mean scores 4 weeks and 2 weeks after the intervention we did not find any statistically significant difference between the two groups. We achieved the same results when we examined cases' and controls' pre and post VAS and TCSS scores independent from each other; no improvement in the assessment based on their 2 and 4 weeks comparisons tests. Laser therapy resulted in improved neuropathy outcomes in diabetic patients who received it relative to the group that received sham therapy, evaluating before and after LLLT assessments. Further studies are needed to test types of lasers, as well as different dosage and exposure levels required in different phase of neuropathic care, so as to obtain reproducible results.
Tesfaye S, Chaturvedi N, Eaton SE, Ward JD, Manes C, Ionescu-Tirgoviste C, Witte DR, Fuller JH; EURODIAB Prospective Complications Study Group. Vascular Risk Factors and Diabetic Neuropathy. N Engl J Med2005;352(4):341-50.
Duby JJ, Campbell RK, Setter SM, White JR, Rasmussen KA. Diabetic neuropathy: an intensive review. Am J Health Syst Pharm 2004;61(2):160-73.
Prathap S, Maiya A, Saraswathi, Dare J. Effect of low level laser irradiation on motor nerve conduction velocity of experimentally induced diabetic neuropathy in wistar rat. JPBMS 2011;13(20):1-7.
Tesfaye S, Kempler P. Painful diabetic neuropathy. Diabetologia 2005;48(5):805-7.
Bingöl U, Altan L, Yurtkuran M. Low-power laser treatment for shoulder pain. Photomed Laser Surg 2005;23(5):459-64.
Venancio Rde A, Camparis CM, Lizarelli Rde F. Low intensity laser therapy in the treatment of temporomandibular disorders: a double-blind study. J Oral Rehabil 2005;32(11):800-7.
Aigner N, Fialka C, Radda C, Vecsei V. Adjuvant laser acupuncture in the treatment of whiplash injuries: a prospective, randomized placebo-controlled trial. Wien Klin Wochenschr 2006;118(3-4):95-9.
Kalinina OV, Alekseeva NV, Burtsev EM. [Infrared laser therapy in distal diabetic polyneuropathy]. Zh Nevrol Psikhiatr Im S S Korsakova 1998;98(6):23-5.
Shablinskaia NB. [Use of physical factors in the complex therapy of patients with diabetic angio- and polyneuropathies of the lower extremities]. Lik Sprava 2002;(5-6):62-5.
Peric Z. [Influence of low-intensity laser therapy on spatial perception threshold and electroneurographic finding inpatients with diabetic polyneuropathy]. Srp Arh Celok Lek2007;135(5-6):257-63.
Shved MI, Dudnik AP. [The medical effect of magneticlaser therapy in patients with diabetic angiopathies of the lower extremities]. Lik Sprava 1996;(10-12):155-8.
Zinman LH, Ngo M, Ng ET, Nwe KT, Gogov S, Bril V. Low-intensity laser therapy for painful symptoms of diabetic sensorimotor polyneuropathy: a controlled trial. Diabetes Care 2004;27(4):921-4.
Bodnar PM, Peshko AO, Prystupiuk OM, Voronko AA, Kyriienko DV, Mykhal'chyshyn HP, Naumova MI.et al. [Laser therapy in diabetes mellitus]. Lik Sprava 1999;(6):125-8.
Laakso EL, Cabot PJ. Nociceptive scores and endorphincontaining cells reduced by low-level laser therapy (LLLT) in inflamed paws of Wistar rat. Photomed Laser Surg 2005;23(1):32-5.
|Issue||Vol 51, No 8 (2013)|
|Diabetic Polyneuropathy Laser Therapy Pain Sensorimotor Disorders|
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