Articles

On Pump versus Off Pump Coronary Artery Bypass Surgery in Patients Over Seventy Years Old with Triple Vessels Disease and Severe Left Ventricle Dysfunction: Focus on Early Clinical Outcomes

Abstract

Cardiovascular disease is the leading reason of morbidity in older people. Coronary artery bypass graft (CABG) surgery is the most common type of operations in world. This study was designed to characterize comparison of early clinical outcome following on pump vs. off pump in patients over 70 years old with triple vessels disease and severe left ventricle dysfunction. 80 patients were divided into two groups: In group A (n=40) on pump CABG was performed with hypothermic cardiopulmonary bypass and cold blood cardioplegic arrest and in group B (n=40) the patients had off pump coronary artery bypass (OPCAB) surgery. Exclusion criteria included emergency or urgent operation, combined valve surgery, history of renal insufficiency (Cr >2 mg/dl), stroke. Early postoperative complications such as occurrence, duration and frequency of recurrence of atrial fibrillation were recorded. All patients underwent Holter monitoring after ICU discharge during their hospital stay. The average age of patients was 79.5±7.5 years. Post operative atrial fibrillation (POAF) occurred in 24 cases (30%); 17 cases (42.5%) related to on pump CABG group and 7 cases (17.5%) related to OPCAB group (P=0.03). The frequency of the recurrence of AF in the on pump group was 3.8±1.3 days and in the off pump group was 2.4±1.1 days (P=0.02). ICU stay in on pump group was 3.6±1.80 days, while for the off pump was 2.5±0.6 days (P=0.001). Also hospital stay duration was 8.5±2.1 days for the on pump group compared to the other group that was 6.34±1.06 days. Off pump in patients over 70 years old with triple vessels disease and severe LV dysfunction is safer than on pump and can reduce POAF, ICU and hospital stay and some early surgical complications.

Angelini GD, Taylor FC, Reeves BC, Ascione R. Early and midterm outcome after off-pump and on-pump surgery in Beating Heart Against Cardioplegic Arrest Studies (BHACAS 1 and 2): a pooled analysis of two randomized controlled trials. Lancet2002;359(9313):1194-9.

Bull DA, Neumayer LA, Stringham JC, Meldrum P, Affleck DG, Karwande SV. Coronary artery bypass grafting with cardiopulmonary bypass versus off-pump cardiopulmonary bypass grafting: does eliminating thepump reduce morbidity and cost? Ann Thorac Surg 2001;71(1):170-3.

Kalavrouziotis D, Buth KJ, Vyas T, Ali IS. Preoperative atrial fibrillation decreases event-free survival following cardiac surgery. Eur J Cardiothorac Surg 2009;36(2):293-9.

Davies RF, Goldberg AD, Forman S, Pepine CJ, Knatterud GL, Geller N, Sopko G, Pratt C, Deanfield J, Conti CR. Asymptomatic Cardiac Ischemia Pilot (ACIP) study twoyear follow-up: outcomes of patients randomized to initial strategies of medical therapy versus revascularization. Circulation 1997;95(8):2037-43.

Baskett R, Buth K, Ghali W, Norris C, Maas T, Maitland

A, Ross D, Forgie R, Hirsch G. Outcomes in octogenarians undergoing coronary artery bypass grafting. CMAJ 2005;172(9): 1183-6.

Chen YB, Shu J, Yang WT, Shi L, Guo XF, Wang FG, Qian YY. Meta-analysis of randomized trials comparing the effectiveness of on-pump and off-pump coronary artery bypass. Chin Med J (Engl) 2012;125(2):338-44.

Forouzannia S Kh, Abdollahi MH, Mirhosseini SJ, Hosseini H, Moshtaghion SH, Golzar A, NaserzadehN, Ghoraishian SM, Emami Meybodi T. Clinical Outcome and Cost in Patients with Off-pump vs. On-PumpCoronary Artery Bypass Surgery. Acta Medica Iranica 2011;49(7):414-9.

Rocha AS, Pittella FJ, Lorenzo AR, Barzan V, Colafranceschi AS, Brito JO, Mattos MA, Silva PR. Age influences outcomes in 70-year or older patients undergoing isolated coronary artery bypass graft surgery. Rev Bras Cir Cardiovasc 2012; 27(1):45-51.

Moller CH, Penninga L, Wetterslev J, Steinbrüchel DA, Gluud C. Clinical outcomes in randomized trials of off- vs. on-pump coronary artery bypass surgery: systematicreview with meta-analyses and trial sequential analyses. Eur Heart J 2008;29(21):2601-16.

Chu D, Bakaeen FG, Dao TK, Lemaire SA, Coselli JS, Huh J. On-pump versus off-pump coronary artery bypass grafting in a cohort of 63,000 patients. Ann Thorac Surg 2009;87(6):1820-6.

Shroyer AL, Grover FL, Hattler B, Collins JF, McDonald GO, Kozora E, Lucke JC, Baltz JH, Novitzky D. Veterans Affairs Randomized On/Off Bypass (ROOBY) Study Group. On-pump versus off-pump coronary-artery bypass surgery. N Engl J Med 2009;361(19):1827-37.

Lemma MG, Coscioni E, Tritto FP, Centofanti P, Fondacone C, Salica A, Rossi A, De Santo T, Di Benedetto G, Piazza L, Rinaldi M,Schinosa AL, De Paulis R, Contino M, Genoni M. On-pump versus off-pump coronary artery bypass surgery in high-risk patients: operative results of a prospective randomized trial (on-off study). J Thorac Cardiovasc Surg 2012;143(3):625-31.

Files
IssueVol 51, No 5 (2013) QRcode
SectionArticles
Keywords
Off pump CABG On pump CABG Outcome Patients over seventy years old

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Mirhosseini SJ, Forouzannia SK, Ali-Hassan-Sayegh S, Hadad-Zadeh M, Abdollahi MH, Moshtaghiom H, Hosseini H. On Pump versus Off Pump Coronary Artery Bypass Surgery in Patients Over Seventy Years Old with Triple Vessels Disease and Severe Left Ventricle Dysfunction: Focus on Early Clinical Outcomes. Acta Med Iran. 1;51(5):320-323.