Comparison of Vitamin D3 Serum Levels in New Diagnosed Patients with Multiple Sclerosis versus Their Healthy Relatives

  • Mehrdokht Mazdeh Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Soroush Seifirad Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Niloofar Kazemi Medical Student, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Mohammad Ali Seifrabie Department of Social Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Arash Dehghan Department of Pathology, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Hamidreza Abbasi Medical Student, Hamadan University of Medical Sciences, Hamadan, Iran.
Keywords:
Multiple Sclerosis, Vitamin D, Vitamin D Deficiency

Abstract

Multiple risk factors are introduced for Multiple Sclerosis (MS). Recent studies have suggested a possible correlation between vitamin D deficiency and an increase risk of MS. This study was therefore undertaken to compare vitamin D levels in new cases of MS and their relatives as healthy controls. Seventy five new diagnosed MS patients and 100 matched healthy controls among their relatives were enrolled in this study. Two groups were matched for gender, age, season in which serum level of vitamin D was checked and region and diet. Serum levels of 25-hydroxy vitamin D was measured, recorded and analyzed. Seventy five patients (57 female and 18 male) and 100 healthy subjects (75 female and 25 male) were enrolled in this study. The mean serum levels of 25-hydroxy vitamin D in case and control groups were 11.31 and 17.9 ng/ml, respectively (P=0.003). Compared to the healthy subject, serum levels of vitamin D were significantly lower in patients with MS. This difference was only significant in women. Observed difference of vitamin D levels of both groups were significant in summer. This study continues to support the role of vitamin D deficiency in MS.

References

Weinstock-Guttman B, Bakhshi R. Combination Therapy for Multiple sclerosis: The Treatment Strategy of the future? CNS Drugs 2004;8(12):777-92.

Zittermann A. Vitamin D in preventive medicine: are we ignoring the evidence? Br J Nutr 2003;89(5):552-72.

Berlanga-Taylor AJ, Ramagopalan SV. Vitamin D and multiple sclerosis: what is the clinical impact? Expert Opin Med Diagn 2013;7(3):227-9.

Hewer S, Lucas R, van der Mei I, Taylor BV. Vitamin D and multiple sclerosis.J Clin Neurosci 2013;20(5):634-41.

Pierrot-Deseilligny C, Souberbielle JC. Contribution of vitamin D insufficiency to the pathogenesis of multiple sclerosis. Ther Adv Neurol Disord 2013;6(2):81-116.

Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio

A. Serum 25-Hydroxyvitamin D levels and Risk of Multiple sclerosis. JAMA 2006;296(23):2832-8.

Soilu-Hanninen M, Laksonen M, Laitinen I, Erlinna J, Lilius E, Mononen I. A longitudinal study of serum 25- hydroxyvitamin D and intact parathyroid hormone levels indicate the important of vitamin D and Calcium homeostasis regulation in Multiple sclerosis. J Neurol Neurosurg Psychiatr 2008;79:152-7.

van der Mei IA, Ponsonby AL, Dwyer T, Blizzard L, Taylor BV, Kilpatrick T, Butzkueven H, McMichael AJ. Vitamin D levels in people with multiple sclerosis andmcommunity controls in Tasmania, Australia. J Neurol 2007;254(5):581-90.

Chris H Polman, Stephen C Reingold, Brenda Banwell, Michel Clanet, Jeffrey A Cohen, Massimo Filippi, LudwigKappos, Fred D Lublin, Xavier Montalban, Paul O'Connor, Magnhild Sandberg-Wollheim, Alan J Thompson, Emmanuelle Waubant, Brian Weinshenker, Jerry SWolinsky. Diagnostic criteria for multiple sclerosis: 2010 Revisions to the McDonald criteria Ann Neurol 2011;69(2): 292-302.

van der Mei IA, Ponsonby AL, Engelsen O, Pasco JA, McGrath JJ, Eyles DW, Blizzard L, Dwyer T, Lucas R, Jones G. The high prevalence of vitamin D insufficiency across Australian populations is only partly explained by season and latitude. Environ Health Perspect 2007;115(8):1132–9.

Smolders J, Damoiseaux J, Menheere P, Hupperts R. Vitamin D as an immune modulator in multiple sclerosis, a review. J Neuroimmunol 2008;194(1-2):7–17.

Gale CR, Martyn CN. Migrant studies in multiple sclerosis. Prog Neurobiol 1995;47(4-5):425–48.

Van Amerongen BM, Dijkstra CD, Lips P, Polman CH.Multiple sclerosis and vitamin D. Eur J Clin Nutr 2004;58:1095-109.

Lucas RM, Ponsonby AL, Dear K, Valery PC, Pender MP, Taylor BV, Kilpatrick TJ, Dwyer T, Coulthard A, Chapman C, van der Mei I, Williams D, McMichael AJ. sun exposure and vitamin D levels may have Role in MS. Neurology 2011;76(6):540-8.

Soilu-Hanninen M, Airas L, Mononen I, Heikkila A, Viljanen M. 25-Hydroxyvitamin D level in serum of theonset of Multiple sclerosis. J Multiple Sclerosis 2005;11(3):266-71.

How to Cite
1.
Mazdeh M, Seifirad S, Kazemi N, Seifrabie MA, Dehghan A, Abbasi H. Comparison of Vitamin D3 Serum Levels in New Diagnosed Patients with Multiple Sclerosis versus Their Healthy Relatives. Acta Med Iran. 51(5):289-292.
Section
Articles