Effects of Diabetes Mellitus Type Ι with or without Neuropathy on Vestibular Evoked Myogenic Potentials

  • Behnoush Kamali Department of Audiology, Faculty of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran.
  • Fahimeh Hajiabolhassan Mail Department of Audiology, Faculty of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran.
  • Jamileh Fatahi Department of Audiology, Faculty of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran.
  • Ensieh Nasli Esfahani Endocrinology and Metabolism Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Javad Sarrafzadeh Department of Physiotherapy, Faculty of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran.
  • Soghrat Faghihzadeh Department of Biostatistics, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Keywords:
Diabetes mellitus type Ι, Saccule, Sternocleidomastoid muscle, Vestibular evoked myogenic potentials, Vestibular System

Abstract

Diabetes mellitus type Ι is a metabolic disorder that affects multiple systems including the inner ear. Patients with diabetes mellitus commonly complain about dizziness, floating sensation, tinnitus and sweating. The aim of this study was to compare vestibular evoked myogenic potentials (VEMPs) between diabetic patients with or without neuropathy. Subjects included 14 patients with diabetes mellitus type Ι with polyneuropathy, 10 patients with diabetes mellitus type Ι without polyneuropathy and 24 healthy volunteers. Range of age in participants was 15-40 years old. The VEMPs were recorded with 500 Hz tone bursts with intensity at 95 dB. There was statistically significant difference between the groups in P13 and N23 latencies (P<0.05). There was no statistically significant difference between groups in absolute and relative amplitudes. Prolonged latencies of the VEMP suggest lesions in the retrolabyrinthine, especially in the vestibulospinal tract.

References

American Diabetes Association: Diagnosis and classification of diabetes mellitus. Diabetes Care 2005; 28(Suppl 1):S37-42.

Bittar RSM, Sunchez TG, Santoro PP, Medeiros IRT. O metabolismo da glucose e o ovid interno Arq otorringol. 1988; 2: 39-44.

Smith TL, Raynor E, Prazma J, Buenting JE, Pillsbury HC. Insulin-dependent diabetic microangiopathy in the inner ear. Laryngoscope 1995; 105(3):236–40.

Biurrun O, Ferrer JP, Lorente J, De Espana R, Gomis R, Traserra J. Asymptomatic electronystagmographic abnormalities in patients with type I diabetes mellitus. ORL J Otorhinolaryngol Relat Spec 1991; 53(6):335-8.

McQueen CT, Baxter A, Smith TL, Raynor E, Yoon SM, Prazma J, Pillsbury HC 3rd. Non-insulin-dependent diabetic microangiopathy in the inner ear. J Laryngol Otol 1999; 113(1):13–8.

Rust KR, Prazma J, Triana RJ, Michaelis OE 4th, PillsburyHC. Inner ear damage secondary to diabetes mellitus. Arch Otolaryngol Head Neck Surg 1992; 118(4):42–53.

Triana RJ, Suits GW, Garrison S, Prazma J, Brechtelsbauer PB, Michaelis OE, Pillsbury HC. Inner ear damage secondary to diabetes mellitus I Changes in aging SHR/Ncp rats. Arch Otolaryngol Head Neck Surg 1991; 117(6):635–40.

Rigon R, Rossi AG, Cóser PL. Otoneurologic findings in Type 1 Diabetes mellitus patients. Bras Otorrinolaringol 2007; 73(1):106-11.

Gawron W, Pospiech L, Orendorz-Fraczkowska K, Noczynska A. Are there any disturbances in vestibular organ of children and young adults with type I diabetes? Diabetologia 2002; 45(5):728-34.

Hall JW.New handbook of auditory evoked responses. 2nd ed. Boston: Pearson education Inc; 2007.

Bektas D, Gazioglu S, Arsalan S, Cobanoglu B, Boz C , Caylan R.VEMP responses are not affected in non-insulindependent diabetes mellitus patients with or without polyneuropathy. Acta Otolaryngol 2008; 128(7):768-71.

Khasanov SA, Vasilyeva VP, Mazovestsky AG. Vestibular function in the early forms of diabetes mellitus. Vestn Otorinolarginol (pol) 1980; 6:34-7.

Kalgenberg KF, Zeigelboim BS, Jurkiewicz AL, Martins- Bassetto J, Vestibulocochlear manifestations in patients with type 1 diabetes mellitus. Bras J Otorrinolariongol 2007; 73(3):353-8.

England JD, Gronseth GS, Franklin G, Miller RG, Asbury AK, Carter GT, Cohen JA, Fisher MA, Howard JF, Kinsella LJ, Latov N, Lewis RA, Low PA, Sumner AJ. American Academy of Neurology; American Association of Electrodiagnostic Medicine;American Academy of Physical Medicine and Rehabilitation. Distal symmetric polyneuropathy: A definition for clinical research. Neurology 2005; 64(2):199-207.

Jorgensen MB, Buch NH. Studies on inner-ear function and cranial nerves in diabetics. Acta Otolaryngol 1961; 107(1):179-82.

Murofushi T, Shimizu K, Takegoshi H, Cheng PW. Diagnostic Value of Prolonged Latencies in the Vestibular Evoked Myogenic Potential. Arch Otolaryngol Head Neck Surg 2001; 127(9):1069-72.

Welgampola MS. Evoked potential testing in neurootology. Cur Opin Neurol 2008; 21(1):29-35.

Perez R, Ziv E, Freeman S, Sichel JY, Sohmer H. Vestibular end-organ impairment in an animal model of type 2 diabetes mellitus. Laryngoscope 2001;/111(1):110-3.

Jerger S, Jerger J. Diabetes Mellitus. In: Jerger S, Jerger J. Alt rações auditivas: um manual para avaliação clínica. São Paulo: Atheneu;1998. p.35-9.

Paula Serra A, Lopes KC, Dorigueto R, Ganança FF. Blood glucose and insulin levels in patients with peripheral vestibular disease. Braz J Otorhinolaryngol 2009; 75(5):701-5.

Almeida FS. Disfunção metabólica tireóidea e otoneurologia. Rev Bras Otorrinolaringol 1998; 64(4):351-8.

Scherer LP, Lobo MB. Pesquisa do nistagmo/vertigem de posição e avaliação eletronistagmográfica em um grupo deindivíduos portadores de diabetes mellitus tipo I. Rev Bras Otorinolaringol 2002; 68(3):355-60.

Camisasca L. Studies on inner-ear function and cranial nerves in diabetics. Acta Otolaryngol 1961; 107(1):179-82.

Murbach VF, Caovilla HH, Munhoz MSL, Ganança MM, Guerrero AI. Distortion Product Otoacoutic Emissions Amplitude Variations During Glucose Tolerance Test and Insulin Titration. Acta ORL 2003; 22(4):32-42.

Mendelsohn M, Roderique J. Cationic changes in endolymph during hypoglycemia. Laryngoscope 1972; 82(8):1533-40.

Goldsher M, Pratt H, Hassan A, Shenhav R, Eliacher I,Kanter Y. Auditory brainstem evoked potentials in insulindependent diabetics with and withoutperipheral neuropathy. Acta Otolaryngol 1986; 102(3-4):204-8.

Niedzielska G, Katska E. ABR disturbances in children with insulin dependent diabetes mellitus. Int J Pediatr Otorhinolaryngol 1998; /44(1):1-4.

Obrebowski A, Pruszewicz A, Swidzinski P, Obrebowska- Karsznia Z, Karlik M, Gawlinski M. The electro physiolgical examinations of hearing in some metabolic disorders. Otolaryngol Pol 1999; 53(5):591–3.

Hendriks JJT, DeJong RN, Hogenhus LAA. Investigations of retrocochlear function in diabetic neuropathy. ClinOtolaryngol 1985; 10:51.

Wang SJ, Yeh TH, Chang CH, Young YH. Consistent Latencies of vestibular evoked myogenic potentials. Ear Hear 2008; 29(6):923-9.

How to Cite
1.
Kamali B, Hajiabolhassan F, Fatahi J, Nasli Esfahani E, Sarrafzadeh J, Faghihzadeh S. Effects of Diabetes Mellitus Type Ι with or without Neuropathy on Vestibular Evoked Myogenic Potentials. Acta Med Iran. 51(2):107-112.
QRcode
Section
Articles