A Novel Compound Heterozygous Mutation (35delg, 363delc) in the Connexin 26 Gene Causes Non-Syndromic Autosomal Recessive Hearing Loss

  • Habib Onsori Mail Department of Cell & Molecular Biology, Marand Branch, Islamic Azad University, Marand, Iran.
  • Mohammad Rahmati Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.AND Department of Clinical Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Davood Fazli Department of Physiology, Payame Noor University, Marand, Iran.
Connexin 26, Hearing loss, Novel mutation, Case report


Mutations in the Connexin 26 (Cx26) gene are a common cause of hereditary hearing loss in different populations. In the present study, an Iranian patient with bilateral hearing loss underwent molecular analysis for the causative mutation. DNA studies were performed for the Cx26 gene by PCR and sequencing methods. We describe a novel compound heterozygous mutation (35delG, 363delC) in the Cx26 gene that is strongly associated with congenital non-syndromic hearing loss (NSHL).


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How to Cite
Onsori H, Rahmati M, Fazli D. A Novel Compound Heterozygous Mutation (35delg, 363delc) in the Connexin 26 Gene Causes Non-Syndromic Autosomal Recessive Hearing Loss. Acta Med Iran. 52(8):638-640.