Prophylactic Effect of Low Dose Vitamin D in Osteopenia of Prematurity: a Clinical Trial Study
Osteopenia of prematurity (OOP) is a preventable disease. Improved survival of premature newborns is associated with an increased incidence of OOP. The purpose of this study was to compare the prophylactic effects of two low doses of vitamin D (200 and 400 IU/Day) on the clinical, biochemical and radiological indices of the rickets of prematurity. In a randomized clinical trial, 60 preterm newborns with birth weight < 2000 g & gestational age < 37 weeks were randomly divided in two groups. Thirty newborns received 200 IU/d of vitamin D in group one and 30 ones received 400 IU/day of vitamin D in group two. On the 6th to 8th weeks of life, serum calcium, phosphate, alkaline phosphates, and 25-hydroxy vitamin D concentrations were measured and x- ray of left wrist and physical examination were performed. Both groups had no difference in biochemical, radiological or clinical presentation of rickets. Current study indicated that low dose vitamin D (200 IU/Day) is enough for prevention of OOP.
Alizadeh P, Naderi F, Sotoudeh K. A Randomized Clinical Trial: Prophylactic effects of vitamin D on different indices of ostopenia of prematurity. Iranian J Public Health 2006;35(3):58-63.
Rigo J, Mohamed MM, Curtis M. Disorders of calcium, phosphorus and magnesium metabolism. In: Martin RJ, Fanaroff AA, walsh MC, editors. Neonatal Perinatal Medicine Diseases of the Fetus and Infant. 9th ed, Philadelphia: Mosby Elsevier; 2010: p. 1550-3.
Winston WK, Reginald C. Calcium and magnesium homeostasis. In: MacDonald MG, Seshia MM, Mullett MD, editors. Avery′s Neonatology Pathophysiology & Mangement of the Newborn. 6th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2005: p. 845-71.
Greenbaum LA. Rickets and hypervitaminosis D. In: Kliegman RM, Jenson HB, Behrman RH, et al. Nelson Textbook of Pediatrics. 18th ed. Philadelphia: Elsverier; 2011: p. 261-3.
Harrison CM, Gibson AT. Osteopenia in preterm infants. Arch Dis Child Fetal Neonatal Ed 2013;98(3):F272-5.
Haschke F, Schilling R, Pietschnig B, et al. Calcium, phosphorus and vitamin D administration in infancy. Monastsschr Kinderheilkd 1992:140(9 suppl1):S13-6.
Vachharajani AJ, Mathur AM, Rao R. Metabolic bonedisease of prematurity. Neo Rev 2009;10(8):e402-11.
Sivert WL. Joint compression therapy in the prevention of osteopenia of prematurity: Current research and future considerations. SOPHIA. (Accessed in May 2, 2014, at http://sophia.stkate.edu/cgi/viewcontent.cgi?article=1006& context=ma_nursing).
Eliakim A, Nemet D. Osteopenia of prematurity. The role of exercise in prevention and treatment. Pediatr Endocrinol Rev 2005;2(4):675-82.
Law Hs, So KW, Ng PC. Osteopenia in neonates: A Review. HK J Pediatr 2007;12(2):118-24.
Taylor SN, Hollis BW, Wanger CL. Vitamin D needs of preterm infants. Neo Rev 2009;10(12):e590-9.
Woonso K, Cheung P. Treatment and prevention of neonatal osteopenia. Curr Paediatr2005;15(2):106-13.
Koo WW, Krug-Wispe S, Neylan M, et al. Effect of threelevels of vitamin D Intake in preterm infants receiving high mineral-containing milk. J Pediatr Gastroentrol Nutr 1995;21(2):182-9.
Gartner LM, Chairperson Kramer MS, Chalmers B, et al.American Academy of Pediatrics. Committee on Nutrition. JOGN 2005:34:367-72.
Backstorm MC, MAKI R, Kuusela AL, et al. Maci. Randomised Controlled Trial of Vit D supplementation on bonedensity and biochemical indices in preterm infants. Arch Dis Child Fetal Neonatal ED 1999;80(3):F161-6.
Cross BK, Vasquez E.Osteopenia of prematurity prevention & treatment. Internet Scientific publications (Accessed in May 17, 2014, at http://ispub.com/IJANP/4/2/7117).
Jacobus CH, Holick MF, Shao Q, et al. Hypervitaminosis D associated with drinking milk. N Engl J Med 1992;326(18):1173-7.
Laing IA, Glass EJ, Hendry GM, et al. Rickets of prematurity: Calcium and phosphors supplementation. JPediatr 1985;106(2):265-8.
Haschke F, Schilling R,Pietschnig B, et al. Calcium, phosphorus and vitamin D administration in infancy. Unsolved questions. Monatsschr Kinderheilkd 1992;140(9 Suppl 1):S13-6.
Markested T, Aksnes L, Finne PH, et al. Vitamin D nutritional status of premature infants supplemented with 500 IU vitamin D per day. Acta Pediatr 1983;72(4):517-20.
Agostoni C, Buonocore G, Carnielli VP, et al. Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroentrol Nutr 2010;50(1):85-91.
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