Human Papilloma Virus and Esophageal Squamous Cell Carcinoma
Abstract
Human papillomavirus (HPV) has also been suggested as an etiology of esophageal squamous cell carcinoma (SCC). The aim of this study was to investigate the prevalence of HPV infection in esophageal SCCs in our region with strict contamination control to prevent false positive results. Thirty cases of esophageal squamous cell carcinomas were chosen by simple random selection in a period of two years. PCR for target sequence of HPV L1 gene was performed on nucleic acid extracted from samples by means of GP5+/GP6+ primers. All tissue samples in both case and control groups were negative for HPV-DNA. Although the number of cases in this study was limited, the contribution of HPV in the substantial number of esophageal SCCs in our region is unlikely.
Devesa SS, Blot WJ, Fraumeni JF Jr. Changing patterns in the incidence of esophageal and gastric carcinoma in the United States. Cancer 1998;83(10):2049-53.
Munoz N, Day NE. Esophageal cancer. In:D. Schottenfeld, Fraumeni JF, editors. Cancer epidemiology and prevention. 3rd ed. New York:Oxford University Press; 1996: p. 681-706.
Parkin DM, Pisani P, Ferlay J, Estimates of the worldwide incidence of 25 major cancers in 1990. Int J Cancer 1999;80(6):827-41.
Holmes RS. Vaughan TL. Epidemiology and pathogenesis of esophageal cancer. Semin Radiat Oncol 2007;17(1):2-9.
Valsecchi MG. Modelling the relative risk of esophageal cancer in a case-control study. J Clin Epidemiol 1992;45(4):347-55.
Turner JR, Shen LH, Crum CP, et al. Low prevalence of human papillomavirus infection in esophageal squamous cell carcinomas from North America:analysis by a highly sensitive and specific polymerase chain reaction-based approach. Hum Pathol 1997;28(2):174-8.
zur Hausen H. Papillomaviruses and cancer:from basic studies to clinical application. Nat Rev Cancer 2002;2(5):342-50.
Doorbar J. The papillomavirus life cycle. J Clin Virol 2005;32 (Suppl 1):S7-15.
Kian Ang K, Harris J, Wheeler R, et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 2010;363(1):24-35.
Schlencht NF. Prognostic value of human papillomavirus in the survival of head and neck cancer patients:an overview of the evidence. Oncol Rep 2005;14(5):1239-47.
Eslami Far A, Aghakhani A, Hamkar R, et al. Frequency of human papillomavirus infection in oesophageal squamous cell carcinoma in Iranian patients. Scand J Infect Dis 2007;39(1):58-62.
Moberg M, Gustavsson I, Gyllensten U. Real-time PCRbased system for simultaneous quantification of human papillomavirus types associated with high risk of cervical cancer. J Clin Microbiol 2003;41(7):3221-8.
Shahsiah R, Khademalhosseini M, Mehrdad N, et al. Human papillomavirus genotypes in Iranian patients with cervical cancer. Pathol Res Pract 2011;207(12):754-7.
Evans MF, Adamson CS, Simmons-Arnold L, et al. Touchdown General Primer (GP5+/GP6+) PCR and optimized sample DNA concentration support the sensitive detection of human papillomavirus. BMC Clin Pathol 2005;5(1):10.
Castillo A, Aguayo F, Koriyama C, et al. Human papillomavirus in esophageal squamous cell carcinoma in Colombia and Chile. World J Gastroenterol 2006;12(38):6188-92.
Shuyama K, Castillo A, Aguayo F, et al. Human papillomavirus in high-and low-risk areas of oesophageal squamous cell carcinoma in China. Br J Cancer 2007;96(10):1554-9.
Souto Damin AP, Guedes Frazzon AP, de Carvalho Damin D, et al. Detection of human papillomavirus DNA in squamous cell carcinoma of the esophagus by auto-nested PCR. Dis Esophagus 2006;19(2):64-8.
Takahashi A, Ogoshi S, Ono H, et al. High-risk human papillomavirus infection and overexpression of p53 protein in squamous cell carcinoma of the esophagus from Japan. Dis Esophagus 1998;11(3):162-7.
Kamath AM, Wu TT, Heitmiller R, et al. Investigation of the association of esophageal carcinoma with human papillomaviruses. Dis Esophagus 2000;13(2):122-4.
Koshiol J, Wei WQ, Kewimer AR, et al. No role for human papillomavirus in esophageal squamous cell carcinoma in China. Int J Cancer 2010;127(1):93-100.
Baseman JG, Koutsky LA. The epidemiology of human papillomavirus infections. J Clin Virol 2005;32(Suppl1):S16-24.
Molijn A, Kleter B, Quint W, et al. Molecular diagnosis of human papillomavirus (HPV) infections. J Clin Virol 2005;32(Suppl 1):S43-51.
Zehbe I, Voglino G, Wilander E, et al. Codon 72 polymorphism of p53 and its association with cervical cancer. Lancet 1999;354(9174):218-9.
Rys PN, Persing DH. Preventing false positives:quantitative evaluation of three protocols for inactivation of polymerase chain reaction amplification products. J Clin Microbiol 1993;31(9):2356-60.
| Files | ||
| Issue | Vol 52, No 3 (2014) | |
| Section | Articles | |
| Keywords | ||
| Squamous cell carcinoma Human papillomavirus Polymerase chain reaction Esophaghus | ||
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