Familial Amyloidosis Cutis Dyschromica: a Case Report
,
Abstract
Amyloidosis cutis dyschromica (ACD) is a rare form of macular amyloidosis characterized by hypo and hyperpigmented macules. Here we described a 20 year old girl with diffuse hypo and hyperpigmentation since she was four years old. Five other members of her family are also involved. Biopsy of hyperpigmented lesions revealed increase of melanin in the basal layer, pigment incontinence and amorphous eosinophilic masses stained positive with Congo red in the papillary dermis. The histopathologic findings were consistent with amyloidosis cutis dyschromica. Other investigations were normal. Dermatologists should consider amyloidosis cutis dyschromica when visit a patient with diffuse hypo and hyperpigmentation.
Morishima T. A clinical variety of localized cutaneous amyloidosis characterized by dyschromia (amyloidosis cutis dyschromica). Jpn J Dermatol Series B 1970;80(1):43-52.
Moriwaki S, Nishigori C, Horiguchi Y, et al. Amyloidosis cutis dyschromica: DNA repair reduction in the cellular response to UV light.Arch Dermatol 1992;128(7):966-70.
Choonhakarn C, Wittayachanyapong S. Familial amyloidosis cutis dyschromica: six cases from three families. J Dermatol 2002;29(7):439-42.
Vijaikumar M, Thappa DM. Amyloidosis cutis dyschromica in two siblings. Clin Exp Dermatol 2001;26(8):674–6.
Bourke JF, Berth-Jones J, Burns DA. Diffuse primary cutaneous amyloidosis. Br J Dermatol 1992;127(6):641-4.
F. Dehghani, et al. Acta Medica Iranica, Vol. 52, No. 2 (2014) 165
Wong CK. History and modern concepts. Clin Dermatol1990;8(1):1-6.
Karadagi AS, Guler Şimsek G. Familial amyloidosis cutis dyschromica. Turk J Med Sci 2010;40(1):151-4.
Garg T, Chander R, Jabeen M, et al. Amyloidosis cutis dyschromica: a rare pigmentary disorder. J Cutan Pathol 2011;38(10):823-6.
Yang W, Lin Y, Yang J, et al. Amyloidosis cutis dyschromica in two female siblings: cases report. BMC Dermatol 2011;11(1):4.
Bulbul Baskan E, Tunalı S, Turan A, et al. Dyschromatosis universalis herediteria: a case report from Turkey. T Klin J Dermatol 2008;18(3):191-4.
| Files | ||
| Issue | Vol 52, No 2 (2014) | |
| Section | Articles | |
| Keywords | ||
| Amyloidosis Congo Red Hypopigmentation Hyperpigmentation | ||
| Rights and permissions | |
|
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
