Neoadjuvant Chemotherapy for Locally Advanced Squamous Carcinoma of Oral Cavity: a Pilot Study

  • Sanambar Sadighi Mail Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.
  • Amanolah Keyhani Department of Head and Neck Surgical Oncology and Reconstructive Surgery, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.
  • Iraj Harirchi Department of Head and Neck Surgical Oncology and Reconstructive Surgery, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.
  • Ata Garajei Department of Head and Neck Surgical Oncology and Reconstructive Surgery, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.
  • Mahdi Aghili Radiotherapy Oncology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.
  • Ali Kazemian Radiotherapy Oncology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.
  • Maziar Motiee Langroudi Department of Ear, Nose and Trout, Valiasr Hospital, Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Kazem Zendehdel Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.
  • Nariman Nikparto Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran.
Keywords:
Oral cavity, Squamous cell carcinoma, Randomized clinical trial, Induction chemotherapy

Abstract

To evaluate the effect of adding neoadjuvant chemotherapy to surgery and radiation therapy for locally advanced resectable oral cavity squamous cell carcinoma, 24 patients with T3 or T4a oral cavity squamous cell carcinoma were randomly assigned to surgery alone or Docetaxel, Cisplatin, and 5-FU (TPF) induction chemotherapy followed by surgery. All patients were planned to receive chemoradiotherapy after surgery. The primary end-points were organ preservation and progression-free-survival. SPSS version 17 was used for data analysis. Median follow-up was 16 months. The median age of the patients was 62 years old (23-75 years). Man/woman ratio was 1.13. The primary site of the tumor was the tongue in most patients (48%). No significant difference was observed between pathologic characteristics of the two groups. Chemotherapy group showed 16% complete pathologic response to TPF. No significant difference in organ preservation surgery or overall survival was detected. However, the patients in the chemotherapy group had longer progression-free-survival (P=0.014). Surgery followed by chemoradiotherapy with or without TPF induction results in similar survival time. However, progression-free-survival improves with the TPF induction chemotherapy. Studies with more patents and new strategies are recommended to evaluate organ preservation improvement and long-term outcomes.

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How to Cite
1.
Sadighi S, Keyhani A, Harirchi I, Garajei A, Aghili M, Kazemian A, Motiee Langroudi M, Zendehdel K, Nikparto N. Neoadjuvant Chemotherapy for Locally Advanced Squamous Carcinoma of Oral Cavity: a Pilot Study. Acta Med Iran. 53(6):380-386.
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