Is the GSTM1 Null Polymorphism a Risk Factor for Primary Angle-Closure Glaucoma among Iranian Population?
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Abstract
Glutathione S-transferases (GSTs) are members of multigenic family which have the essential functionin cells as an antioxidant. In the present study we studied the polymorphism of GSTT1 and GSTM1 deletion genotypes in Iranian patients with primary closed angle glaucoma (PCAG) compared to healthy subjects. We conducted a study of 41 PCAG patients (24 women, 17 men) and 100 healthy participants (57 women, 43 men) to determine the prevalence of GSTT1 and GSTM1 deletion genotypes and the risk of PCAG, which were determined by multiplex polymerase chain reaction. Genotypes of GSTM1 and GSTT1 null deletions were determined in 22 (53.7%) and 7 (17.1%) patients with PCAG and 34 (34%) and 15 (15%) in healthy participants. Comparison of patients and healthy ones regarding GSTM1 and GSTT1 genotypes revealed increase of GSTM1 null deletions genotypes’ in patients with PCAG (P=0.03). It was concluded that the increased frequencies of GSTM1 null in patients with PCAG could be associated with a risk factor for incidence of PCAG in the Iranian population.
Abu-Amero KK, Morales J, Mohamed GH, et al. Glutathione S-transferase M1 and T1 polymorphisms in Arab glaucoma patients. Mol Vis 2008;14:425-30.
Amini H, Javadi MA, Yazdani Sh, et al. The Prevalence of Glaucoma in Tehran, Iran. Iran J Ophthalmic Res 2007;2(2):93-10.
Zimmerman TJ, Kooner KS, editors. Primary Angle-Closure Glaucoma. 1st ed. New York: Thieme; 2001: p. 81-8.
Sacca S, Izzotti A, Rossi P, et al. Glaucomatous outflow pathway and oxidative stress. Exp Eye Res 2007;84:389-99.
Moasser E, Kazemi-Nezhad R, Saadat M, et al. Study of the association between glutathione S-transferase (GSTM1, GSTT1, GSTP1) polymorphisms with type II diabetes mellitus in southern of Iran. Mol Biol Rep 2012;39(12):10187-92.
Sekine Y, Hommura S, Harada SH. Frequency of glutathione-S-transferase 1 gene deletion and its possible correlation with cataract formation. Exp Eye Res 1995;60(2):159-63.
Yildirim O, Aras NA, Tamer L, et al. May glutathione STransferase M1 positive genotypeafford protection against primary open-angle glaucoma? Greafes Arch Clin Exp Ophthalmol 2005;243(4):327-33.
Unal M, Guven M, Devranoglu k, et al. Glutathione transferase M1 and T1 genetic polymorphisms are related to the risk of primary open-angle glaucoma: a study in a Turkish population. Br J Ophthalmol 2007;91(4):527-530.
Ritch R, Lowe RF. Angle-Closure Glaucoma: Mechanisms and Epidemiology. In: Ritch R, Shields MB, Krupin T, editors. The Glaucomas. 2nd ed. St. Louis: Mosby; 1996: p. 801-19.
Quigley HA, Friedman DS, Congdon NG. Possible mechanisms of primary angle-closure and malignant glaucoma. J Glaucoma 2003;12(2):167-80.
Schlotzer-Schrehardt U, Naumann GO. Ocular and Systemic Pseudoexfoliation Syndrome. Am J Ophthalmol 2006;141(5):921-37.
Pache M, Flammer J. Sick eye in a sick body: Systemic findings in patients with primary open angle glaucoma. Surv Ophthalmol 2006;51(3):179-212.
Izzotti A, Bagnis A, Sacca SC. The role of oxidative stress in glaucoma. Mutat Res 2006;612(2):105-14.
Osborne NN, Chidlow G, Layton CJ, et al. Optic nerve and neuroprotection strategies. Eye 2004;18(11):1075-84.
Izzotti A, Sacca SC, Cartiglia C, et al. Oxidative deoxyribonucleic acid damage in the eyes of glaucoma patients. Am J Med 2003;114(8):638-46.
Ferreira SM, Reides CG, Lerner FS, et al. Evidence of Oxidative Stress Damage in Glaucoma. INTECH. (Accessed in July 2014, 14, at http://www.intechopen.com/books/themystery-of-glaucoma/evidence-of-oxidative-stress-damagein-glaucoma).
Yang J, Tezel G, Patil RV, et al. Serum autoantibody against glutathione Stransferase in patients with glaucoma. Invest Ophthalmol Vis Sci 2001;42(6):1273-6.
Yildirim O, Ates NA, Tamer L, et al. May glutathione STransferase M1 positive genotypeafford protection against primary open-angle glaucoma? Greates Arch Clin Exp Ophthalmol 2005;243(4):327-33. 19Rossini A, Rapozo DCM, Amorim LMF, et al. Frequencies of GSTM1, GSTT1, and GSTP1 polymorphisms in a Brazilian population. Genet Mol Res 2002;1(3):233-40.
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| Issue | Vol 53, No 2 (2015) | |
| Section | Articles | |
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| GSTM1 Polymorphism Angle-closure glaucoma Iran | ||
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