Kikuchi-Fujimoto Disease: a Case Report

  • Mozaffar Aznab Mail Department of Internal Medicine, Taleghani Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
  • Naser Kamalian Department of Pathology, Tehran University of Medical Sciences, Tehran, Iran.
  • Jaffar Navabi Department of Internal Medicine, Taleghani Hospital, Kermanshah, Iran.
  • Kaveh Kavianimoghadam Department of Paramedical, School of Medicine, Kermanshah of University Medical Sciences, Kermanshah, Iran.
Kikuchi-Fujimoto disease, Histiocytic necrotizing lymphadenitis


Kikuchi-Fujimoto disease or histiocytic necrotizing lymphadenitis is an idiopathic, self-limiting disorder and predominantly affects young women. We report a 35-year-old female who presented with soft to firm cervical lymphadenopathy and neck pain. She had multiple enlarged cervical nodes. Examination of other systems was normal. Lymph node biopsy was performed, and the histological features, and immunohistochemistry confirmed the diagnosis. The Patient was treated with non-steroidal anti-inflammatory drugs and low-dose prednisolone. A significant decrease in the size of lymph node and relief of neck pain occurred. During four years of follow-up, the patient developed no malignant disease or systemic and autoimmune diseases such as systemic lupus erythematosus. Kikuchi-Fujimoto disease is rare, clinicians should be aware of this condition as early diagnosis of the disease will lessen concerns of the patient's family.


Kikuchi M. Lymphadenitis showing focal reticulum cell hyperplasia with nuclear debris and phagocytes. Acta Hematol Jpn 1972;35:379-80.

Fujimoto Y, Kozima Y, Yamaguchi K. Cervical subacute necrotizing lymphadenitis: a new clinicopathologic entity. Naika 1972;20:920-7.

Bosch X, Guilabert A, Miquel R, et al. Enigmatic Kikuchi- Fujimoto disease: a comprehensive review. Am J Clin Pathol 2004;122(1):141-52.

Lin HC, Su CY, Huang CC, et al. Kikuchi's disease. A review and analysis of 61 cases. Otoralyngol Head Neck Surg 2003;128(5):650-3.

Kuo T. Kikuchi's disease (histiocytic necrotising lymphadenitis): a clinicopathologic study of 79 cases with an analysis of histologic subtypes, immunohistology and DNA ploidy. Am J Surg Pathol 1995;19(7):798-809.

Lee HY, Huang YC, Lin TY, et al. Primary Epstein-Barr virus infection associated with Kikuchi’s disease and hemophagocytic lymphohistiocytosis: a case report and review of the literature. J Microb Immunol Infect 2010;43(3):253-7.

Atarashi K, Yoshimura N, Nodera H, et al. Recurrent histiocytic necrotizing lymphadenitis (Kikuchi’s disease) in an human T lymphotropic virus type I carrier. Intern= Med 1996;35(10):821-5.

Pileri SA, Sabattini E, Costigliola P, et al. Kikuchi’s lymphadenitis and HIV infection. AIDS 1991;5(4):459-61.

Hollingsworth HC, Peiper SC, Weiss LM, et al. An investigation of the viral pathogenesis of Kikuchi-Fujimoto disease: lack of evidence for Epstein-Barr virus or human herpesvirus type 6 as the causative agents. Arch Pathol Lab Med 1994;118(2):134-40.

Chen PH, Huang YF, Tang CW, et al. Kikuchi-Fujimoto disease: an amazing response to hydroxychloroquine. Eur J Pediatr 2010;169(12):1557-9.

Jang YJ, Park KH, Seok HJ. Management of Kikuchi's disease using glucocorticoid. J Laryngol Otol 2000;114(9):709-11.

Dorfman RF. Histiocytic necrotizing lymphadenitis of Kikuchi and Fujimoto. Arch Pathol Lab Med 1987;111(11):1026-9.

George TI, Jones CD, Zehnder JL , et al. Lack of human herpesvirus 8 and Epstein-Barr virus in Kikuchi’s histiocytic necrotizing lymphadenitis. Hum Pathol 2003;34(2):130-5.

How to Cite
Aznab M, Kamalian N, Navabi J, Kavianimoghadam K. Kikuchi-Fujimoto Disease: a Case Report. Acta Med Iran. 53(11):725-727.
Case Report(s)