Association of DC-SIGN and DC-SIGNR Repeat Regions with Susceptibility to Pulmonary Tuberculosis in Zahedan, Southeastern Iran
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Abstract
There are conflicting results concerning DC-SIGN and DC-SIGNR VNTR polymorphisms. The present study aimed to evaluate the possible association between DC-SIGN as well as DC-SIGNR VNTR polymorphisms and pulmonary tuberculosis (PTB) in a sample of Iranian population. This case-control study was done on 171 PTB and 161 healthy subjects. The variants were detected by polymerase chain reaction (PCR). DC-SIGNR VNTR genotypes in cases were 12.7% for 5/5, 2.4% for 6/5, 32.7% for 7/7, 38.2% for 7/5, 5.5% for 7/6, 1.2% for /5, 0.6% for 9/6, 6.7% for 9/7 in PTB patients and 19.7% for 5/5, 2.0% for 6/5, 31.6% for 7/7, 37.5% for 7/5, 5.7% for 7/6, 0.0% for 9/5, 0.7% for 9/6, 2.6% for 9/7 in controls. The findings showed no significant association between DC-SIGNR VNTR polymorphism and PTB. All subjects in cases and controls were 7/7 genotype regarding DC-SIGN VNTR polymorphism. Our data propose that DC-SIGNR VNTR, as well as DC-SIGN VNTR, were not associated with the risk of PTB in a sample of Iranian population.
Barry CE, 3rd, Boshoff HI, Dartois V, et al. The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. Nature Rev Microb 2009;7(12):845-55.
Stein CM. Genetic epidemiology of tuberculosis susceptibility: impact of study design. PLoS Pathog 2011;7(1):e1001189.
de Wit E, van der Merwe L, van Helden PD, et al. Gene- gene interaction between tuberculosis candidate genes in a South African population. Mammalian genome: official journal of the International Mammalian Genome Society 2011;22(1-2):100-10.
Hashemi M, Sharifi-Mood B, Nezamdoost M, et al. Functional polymorphism of interferon-gamma (IFN-gamma) gene +874T/A polymorphism is associated with pulmonary tuberculosis in Zahedan, Southeast Iran. Prague Med Rep 2011;112(1):38-43.
Naderi M, Hashemi M, Pourmontaseri Z, et al. TIRAP rs8177374 gene polymorphism increased the risk of pulmonary tuberculosis in Zahedan, southeast Iran. Asian Pac J Trop Med 2014;8:451-4.
Bahari G, Hashemi M, Taheri M, et al. Association of IRGM polymorphisms and susceptibility to pulmonary tuberculosis in Zahedan, Southeast Iran. Sci World J 2012;2012:950801.
Hashemi M, Eskandari-Nasab E, Moazeni-Roodi A, et al. Association of CTSZ rs34069356 and MC3R rs6127698 gene polymorphisms with pulmonary tuberculosis. Int J Tuberc Lung Dis 2013;17(9):1224-8.
Naderi M, Hashemi M, Taheri M, et al. CD209 promoter -n336 A/G (rs4804803) polymorphism is associated with susceptibility to pulmonary tuberculosis in Zahedan, southeast Iran. J Microbiol Immunol Infect 2014;47(3):171-5.
Pathak SK, Skold AE, Mohanram V, et al. Activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), DC-SIGN and beta-2 integrins. J Biol Chem 2012;287(17):13731-42.
Tailleux L, Schwartz O, Herrmann JL, et al. DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells. J Exp Med 2003;197(1):121-7.
Geijtenbeek TB, Torensma R, van Vliet SJ, et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 2000;100(5):575-85.
Li H, Yu XM, Wang JX, et al. The VNTR polymorphism of the DC-SIGNR gene and susceptibility to HIV-1 infection: a meta-analysis. PloS One 2012;7(9):e42972.
Mitchell DA, Fadden AJ, Drickamer K. A novel mechanism of carbohydrate recognition by the C-type lectins DC-SIGN and DC-SIGNR. Subunit organization and binding to multivalent ligands. J Biol Chem 2001;276(31):28939-45.
Feinberg H, Mitchell DA, Drickamer K, et al. Structural basis for selective recognition of oligosaccharides by DC- SIGN and DC-SIGNR. Science 2001;294(5549):2163-6.
Guo Y, Feinberg H, Conroy E, et al. Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR. Nat Struct Mol Biol 2004;11(7):591-8.
Naderi M, Hashemi M, Kouhpayeh H, et al. The status of serum procalcitonin in pulmonary tuberculosis and nontuberculosis pulmonary disease. JPMA 2009;59(9):647-8.
Alavi-Naini R, Hashemi M, Mohagegh-Montazeri M, et al. Glutaraldehyde test for rapid diagnosis of pulmonary tuberculosis. Int J Tubercs Lung Dis 2009;13(5):601-5.
Hashemi M, Moazeni-Roodi AK, Fazaeli A, et al. Lack of association between paraoxonase-1 Q192R polymorphism and rheumatoid arthritis in southeast Iran. Genet Mol Res 2010;9(1):333-9.
Liu H, Zhu T. Determination of DC-SIGN and DC-SIGNR repeat region variations. Methods Mol Biol 2005; 304:471-81.
Alagarasu K, Selvaraj P, Swaminathan S, et al. CCR2, MCP-1, SDF-1a & DC-SIGN gene polymorphisms in HIV-1 infected patients with & without tuberculosis. Indian J Med Res 2009;130(4):444-50.
Barreiro LB, Neyrolles O, Babb CL, et al. Length variation of DC-SIGN and L-SIGN neck-region has no impact on tuberculosis susceptibility. Hum Immunol 2007;68(2):106-12.
Gomez LM, Anaya JM, Sierra-Filardi E, et al. Analysis of DC-SIGN (CD209) functional variants in patients with tuberculosis. Hum Immunol 2006;67(10):808-11.
Ben-Ali M, Barreiro LB, Chabbou A, et al. Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients. Hum Immunol 2007;68(11):908-12.
da Silva RC, Segat L, da Cruz HL, et al. Association of CD209 and CD209L polymorphisms with tuberculosis infection in a Northeastern Brazilian population. Mol Biol Rep 2014;41(8):5449-57.
Stead WW, Senner JW, Reddick WT, et al. Racial differences in susceptibility to infection by Mycobacterium tuberculosis. N Engl J Med 1990;322(7):422-7.
Xu L, Li Q, Ye H, et al. The nine-repeat DC-SIGNR isoform is associated with increased HIV-RNA loads and HIV sexual transmission. J Clin Immunol 2010;30(3):402-7.
Zhou T, Chen Y, Hao L, et al. DC-SIGN and immunoregulation. Cell Molr Immunol 2006;3(4):279-83.
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| Issue | Vol 54, No 5 (2016) | |
| Section | Original Articles | |
| Keywords | ||
| Tuberculosis DC-SIGN DC-SIGNR VNTR Polymorphism | ||
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