The Complete Response to Targeted Drugs Without Surgery or Radiotherapy: A Case of Pituitary Metastasis From Renal Cell Carcinoma
Abstract
Pituitary gland metastasis was seen in elderly patients, and the incidence of pituitary metastasis is 1% to 4% of all cancer patients. Renal cell carcinoma is a primary malignancy in only 2.6% of pituitary metastases. We reported a 50-year-old man with pituitary metastasis from renal cell carcinoma that had signs of diabetes insipidus. He had multiple lesions in both lungs, and bone scan involved L12 and L1 vertebrates. He was treated with combination bevacizumab 600 mg/month and sunitinib 50 mg/D for four weeks with two weeks rest for 6 months. Treatment with targeted drugs without surgery of pituitary or radiotherapy improved metastatic renal cell carcinoma in the patient.
Yang L, Yu SY, Hu GY. Pituitary metastasis from a renal cell carcinoma progressed after sorafenib treatment. Chin J Cancer. 2013;32(6):353-6.
Kramer CK, Ferreira N, Silveiro SP, et al. Pituitary gland metastasis from renal cell carcinoma presented as a non-functioning macroadenoma. Arq Bras Endocrinol Metabol. 2010;54(5):498-501.
Kim YH, Lee BJ, Lee KJ, et al. A case of pituitary metastasis from breast cancer that presented as left visual disturbance. J Korean Neurosurg Soc. 2012;51:94–97.
Hwang JM, Kim YH, Kim TM, et al. Differential diagnosis and management of a pituitary mass with renal cell carcinoma. J Korean Neurosurg Soc. 2013 Aug;54(2):132-5.
Gore ME, Hariharan S, Porta C, et al. Sunitinib in metastatic renal cell carcinoma patients with brain metastases. Cancer. 2011;117:501–509.
Helgason HH, Mallo HA, Droogendijk H, et al. Brain metastases in patients with renal cell cancer receiving new targeted treatment. J Clin Oncol. 2008;26:152–154.
Ratti M, Passalacqua R, Poli R, et al. Pituitary gland metastasis from rectal cancer: report of a case and literature review. Pituitary gland metastasis from rectal cancer: report of a case and literature review. Springerplus. 2013 Sep 16;2:467.
Files | ||
Issue | Vol 54, No 9 (2016) | |
Section | Case Report(s) | |
Keywords | ||
Diabetes insipidus Pituitary metastasis Renal cell carcinoma Sunitinib |
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