Comparison of Serum LP-PLA2 Level and some Nutritional Factors between Well-Controlled and Poorly-Controlled Diabetic Patients
-
Ali Cheraghi
,
Maryam Mahmoudi
,
Korosh Jafarian
,
Mohammadreza Eshraghian
,
Sanaz Soltani
,
Mahnaz Zarei
,
Farjam Godarzi
,
Yas Kalikias
,
Mahmoud Jalali
Abstract
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is produced by inflammatory cells, bound to LDL and other lipoproteins, and hydrolyzes oxidized phospholipids in LDL. Type 2 diabetes is the most common form of diabetes some investigations show the association of lipoprotein-associated phospholipase A2 mass and activity with the incidence of cardiovascular disease (CVD) in populations with high prevalences of insulin resistance and diabetes. This study is a cross-sectional descriptive and analytic study on 80 individuals with diabetes referring to the Tehran Diabetes Association. Patients divided into two groups (well-controlled and poorly controlled) based on their HbA1C. Personal information, anthropometric assessments (including height, weight, waist circumference and hip circumference) and semi-quantitative 147 items FFQ was used and vein blood samples were taken. After plasma separation, blood sample used for FBS, HbA1c and LP-PLA2 measurement. The independent sample T test was used for comparing means. Data analyses showed a significant difference between weight and WHR (waist to hip ratio) means in two studied groups, also there was a statistically significant difference in food intake (Energy, carbohydrate, protein, micronutrients percent and some of the micronutrients). FBS, HbA1C and LP-PLA2 means showed statistically significant difference (P<0/001) between two groups. This study showed LP-PLA2 is elevated in poorly-controlled patients compared to well-controlled diabetic patients, which may suggest some nutritional factors contributing to the regulation of this enzyme.
Haghdoost AA, Rezazadeh-Kermani M, Sadghirad B, et al. Prevalence of type 2 diabetes in the Islamic Republic of Iran: systematic review and meta-analysis. East Mediterr Health J 2009;15(3):591-9.
Zalewski A, Nelson JJ, Hegg L, et al. Lp-PLA2: a new kid on the block. Clin Chem 2006;52(9):1645-50.
Caslake MJ, Packard CJ, Suckling KE, et al. Lipoproteinassociated phospholipase A(2), platelet-activating factor acetylhydrolase: a potential new risk factor for coronary artery disease. Atherosclerosis 2000;150(2):413-9.
Packard CJ, O’Reilly DSJ, Caslake MJ, et al. Lipoprotein- Associated Phospholipase A2 as an Independent Predictor of Coronary Heart Disease. N Engl J Med 2000;343(16):1148-55.
Khuseyinova N, Imhof A, Rothenbacher D, et al. Association between Lp-PLA2 and coronary artery disease: focus on its relationship with lipoproteins and markers of inflammation and hemostasis. Atherosclerosis 2005;182(1):181-8.
O’Donoghue M, Morrow DA, Sabatine MS, et al. Lipoprotein-associated phospholipase A2 and its association with cardiovascular outcomes in patients with acute coronary syndromes in the PROVE IT-TIMI 22 (Pravastatin Or atorVastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction) trial. Circulation 2006;113(14):1745-52.
Scoppola A, Testa G, Frontoni S, et al. Effects of insulin on cholesterol synthesis in type II diabetes patients. Diabetes Care 1995;18(10):1362-9.
Sowers JR, Epstein M. Diabetes Mellitus and Associated Hypertension, Vascular Disease, and Nephropathy an Update. Hypertension 1995;26(6 Pt 1):869-79.
Wang Y, Rimm EB, Stampfer MJ, et al. Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men. Am J Clin Nutr 2005;81(3):555-63.
Schmidt MI, Duncan BB, Canani LH, et al. Association of waist-hip ratio with diabetes mellitus. Strength and possible modifiers. Diabetes Care 1992;15(7):912-4.
Xie X, Liu Q, Wu J, et al., Impact of cigarette smoking in type 2 diabetes development. Acta Pharmacol Sin 2009;30(6):784-7.
Xu J, Eilat-Adar S, Loria CM, et al. Macronutrient intake and glycemic control in a population-based sample of American Indians with diabetes: the Strong Heart Study. Am J Clin Nutr 2007;86(2):480-7.
Sinclair AJ, Taylor PB, Lunec J, et al. Low plasma ascorbate levels in patients with type 2 diabetes mellitus consuming adequate dietary vitamin C. Diabet Med J Br Diabet Assoc 1994;11(9):893-8.
Ahn HJ, Min KW, Cho Y-O. Assessment of vitamin B6 status in Korean patients with newly diagnosed type 2 diabetes. Nutr Res Pract 2011;5(1):34-9.
Sales CH, Pedrosa LFC, Lima JG, et al. Influence of magnesium status and magnesium intake on the blood glucose control in patients with type 2 diabetes. Clin Nutr Edinb Scotl 2011;30(3):359-64.
Song Y, Manson JE, Buring JE, et al. Dietary Magnesium Intake in Relation to Plasma Insulin Levels and Risk of Type 2 Diabetes in Women. Diabetes Care 2004;27(1):59-65.
Song Y, Manson JE, Buring JE, et al. Dietary magnesium intake in relation to plasma insulin levels and risk of type 2 diabetes in women. Diabetes Care 2004;27(1):59-65.
de Jager J, Kooy A, Lehert P, et al. Long term treatment with metformin in patients with type 2 diabetes and risk of vitamin B-12 deficiency: randomised placebo controlled trial. BMJ 2010;340:c2181.
De Luis DA, Fernandez N, Aller R, et al. Relation between total homocysteine levels and beer intake in patients with diabetes mellitus Type 2. Ann Nutr Metab 2003;47(3-4):119-23.
Mahan LK, Escott-Stump S, Raymond JL, et al, editors. Krause’s Food and the Nutrition Care Process. 12th ed. Elsevier/Saunders, St Louis, MO; 2012: p. 1255.
Schianca GPC, Rossi A, Sainaghi PP, et al. The Significance of Impaired Fasting Glucose Versus Impaired Glucose Tolerance Importance of insulin secretion and resistance. Diabetes Care 2003;26(5):1333-7.
Manley S. Haemoglobin A1c--a marker for complications of type 2 diabetes: the experience from the UK Prospective Diabetes Study (UKPDS). Clin Chem Lab Med 2003;41(9):1182-90.
Nelson TL, Biggs ML, Kizer JR, et al. Lipoproteinassociated phospholipase A2 (Lp-PLA2) and future risk of type 2 diabetes: results from the Cardiovascular Health Study. J Clin Endocrinol Metab 2012;97(5):1695-70.
Hatoum IJ, Hu FB, Nelson JJ, et al. Lipoprotein-associated phospholipase A2 activity and incident coronary heart disease among men and women with type 2 diabetes. Diabetes 2010;59(5):1239-43.
Wong C-K, White HD. Effects of dietary factors on lipoprotein-associated phospholipase A(2) (Lp-PLA (2)). Curr Atheroscler Rep 2011;13(6):461-6.
Hatoum IJ, Nelson JJ, Cook NR, et al., Dietary, lifestyle, and clinical predictors of lipoprotein-associated phospholipase A2 activity in individuals without coronary artery disease. Am J Clin Nutr 2010;91(3):786-93.
Brilakis ES, McConnell JP, Lennon RJ, et al., Association of lipoprotein-associated phospholipase A2 levels with coronary artery disease risk factors, angiographic coronary artery disease, and major adverse events at follow-up. Eur Heart J 2005;26(2):137-44 .
Vinson A, Mahaney MC, Diego VP, et al., Genotype-bydiet effects on co-variation in Lp-PLA2 activity and LDLcholesterol concentration in baboons fed an atherogenic diet. J Lipid Res 2008;49(6):1295-302 .
Zalewski A, Macphee C. Role of Lipoprotein-Associated Phospholipase A2 in Atherosclerosis Biology, Epidemiology, and Possible Therapeutic Target. Arterioscler Thromb Vasc Biol 2005;25(5):923-31.
Bazzano LA. Effects of soluble dietary fiber on lowdensity lipoprotein cholesterol and coronary heart disease risk. Curr Atheroscler Rep 2008;10(6):473-7 .
Zunft HJF, Lüder W, Harde A, al. Carob pulp preparation rich in insoluble fibre lowers total and LDL cholesterol in hypercholesterolemic patients. Eur J Nutr 2003;42(5):235-42 .
Atik B, Johnston SC, Dean D. Association of Carotid Plaque Lp-PLA2 with Macrophages and Chlamydia pneumoniae Infection among Patients at Risk for Stroke. PLoS One 2010;5(6):e11026.
Antoniades C, Antonopoulos AS, Tousoulis D, et al. Homocysteine and coronary atherosclerosis: from folate fortification to the recent clinical trials. Eur Heart J 2009;30(1):6-15.
Chen KJ, Pan WH, Yang FL, et al. Association of B vitamins status and homocysteine levels in elderly Taiwanese. Asia Pac J Clin Nutr 2005;14(3):250-5.
Miodownik C, Lerner V, Vishne T, et al. High-dose vitamin B6 decreases homocysteine serum levels in patients with schizophrenia and schizoaffective disorders: a preliminary study. Clin Neuropharmacol 2007;30(1):13-7.
Krajcovicova-Kudlackova M, Ginter E, Blazicek P, et al. Homocysteine and vitamin C. Bratisl Lekárske Listy 2002;103(4-5):171-3.
Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D, and Fluoride. The National Academies Press. (Accessed in May 2015, 2, at http://www.nap.edu/catalog.php?record_id=5776).
| Files | ||
| Issue | Vol 53, No 11 (2015) | |
| Section | Original Article(s) | |
| Keywords | ||
| LP-PLA2 Well-controlled diabetes Poorly-controlled diabetes Nutrition | ||
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