Survey of Nerve Fiber Layer Thickness in Anisometropic and Strabismic Amblyopia
To investigate the effect of anisometropic and strabismic amblyopia on the nerve fiber layer thickness. This cross-sectional study was done on 54 amblyopic subjects, equally in both strabismic and anisometropic groups. The thickness otonerve fiber layer measured in superior, inferior, nasal, temporal quadrants and as a whole in both eyes of both groups. The means of thickness were compared in amblyopic and sound eyes. In strabismus group, the average nerve fiber layer thickness of the sound eye , in superior, inferior, nasal and temporal quadrants and as a whole were 113.23±14, 117.37±25, 68.96±6, 69.55±14 and 93.40±8 microns respectively. In amblyopic eyes of the same group, these measurements were 103.11±18, 67.74±11, and 69.59±16 and 89.59±12 microns in superior, inferior, nasal, temporal quadrants and as whole respectively. In anisometropic groups, the sound eye measurements were as 130.96±22, 129.07±29, 80.62±12, and 83.88±20 and 107.7±13 microns in superior, inferior, nasal and temporal quadrants and as a whole orderly. In amblyopic eyes of this group the mean thicknesses were 115.63±29, 133.15±25, 78.8±15, 80.2±16 and 109.17±21 microns in superior, inferior, nasal, temporal quadrants and as a whole respectively. Statistically, there were no significant differences between amblyopic and sound eyes (P>0.5). Our study did not support any significant change in a nerve fiber layer thickness of amblyopic patients; however, decreased thickness in superior and nasal quadrants of strabismic amblyopia and except inferior quadrant and as a whole. These measurements may be a clue for management and prognosis of amblyopia in old age.
Lemberts P. Optic nerve hypoplasia and small eyes in presumed amblyopia. J AAPOS 2000;4:258-266.
Arden GB, Wooding SL. Pattern ERG in Amblyopia.Invest Ophthalmol Vis Sci 1985;26:88-96.
Kiorpes L, Kiper DC, OKeefe LP, Cavanaugh JR, Movshon JA. Neurona l correlates of amblyopia in the visual cortex of macauque monkeys with experimentalstrabismus and anisometropia. J Neurosci 1998;18:6411-24.
Yoon SW, Park WH,Baek SH, Kong SM. The thicknes sof macular retinal layer and peripapillary retinal nerve
fiber layer in patients with hyperopic nisometropicamblyopia. Korean J Ophthalmol 2005;19:62-7.
Yen, Cheng CY, Wang AG. Retinal nerve fiber layer thickness in unilateral amblyopia. Invest Ophthalmol,
Korean J Ophthalmol 2005;19:62-7.
Colen TP, de Faber JT, Lemij HG. Retinal nerve fiber layer thickness in human strabismic amblyopia. Binocular
Vis Strabimus Q 2000;15:141-6.
May-Yung Y, Ching-Yu C, An-Guor W.Retinal nerve fiber layer thickness in unilateral amblyopia. InvestOphthalmol Vis Sci 2004;45:2224-30.
Ann Dickmann, Sergio Petroni, AnnabellaSalerni,Roberto Dell Omo, Emili o Balestrazzi.Unilateral amblyopia: An optical coherence tomography study. J AAPOS 2009;13:148-50.
Altintas O, Yuksel N, Ozkan B, Cglar Y. The thickness of the retinal nerve fiber layer, macular thickness,and
macular volume in patients with strabismic Amblyopia. J Pediatr Opthalmol Strabismus 2005;42:216-21.
Huynh SC, Samarawickrama C, Wang XY, Rochtchina E,Wong TY, Gole GA, et al. Macular and Nerve Fiber
Layer Thickness in Amblyopia. Opthalmol2009;116:1604-9.
Michael X. Repka, Nitza Goldenberg-Cohen, Allison R.Edwards. Retinal Nerve Fiber Layer Thickness in
Amblyopic Eyes. Am J Ophthalmol 2006;142:247-51
Andalib.D,Javadzadeh A,Nabai R,Amizadeh Y. Macular and retinal nerve fiber layer thickness in unilateral
anisometropic or strabismic amblyopia. J Pediatr Ophthalmol Strabismus 2013;50:218-21.
Yakar K, Kan E, Alan A, Hanifi Alp M, Ceylan T.Retinal Nerve Fibre Layer and Macular Thicknesses in Adults with Hyperopic Anisometropic Amblyopia. JOphthalmol 2015;2015:946467.
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