Growth Status and Its Relationship with Serum Lipids and Albumin in Children with Cystic Fibrosis
-
Gholam Hossein Fallahi
,
Sahar Latifi
,
Maryam Mahmoudi
,
Davood Kushki
,
Mohammad Taghi Haghhi Ashtiani
,
Afsaneh Morteza
,
Nima Rezaei
Abstract
Cystic fibrosis (CF) is an autosomal recessive disease, which affects many organs as it impairs chloride channel. This study was performed to evaluate growth status and its relationship with some laboratory indices such as Cholesterol (chol), Triglyceride (TG), albumin and total protein in children with CF referred to pediatrics center. This study was designed as a cross-sectional study in one year section. Demographic features were compared with standard percentiles curves. Chol, TG, albumin, total protein, prothrombin time, and hemoglobin were measured. Stool exams were also performed. A questionnaire was designed to obtain a history of the first presentation of disease, birth weight, type of labor and parent relativity. In 52% of patients, failure to thrive (FTT) was the first presentation. Steatorrhea and respiratory infections were the first presentations, which were seen in 13.7% and 33% of the cases, respectively. The weight of 88% of patients was below the 15th percentile while 82% had a height percentile below 15th. Head circumference in 53% of patients was below the 15th percentile. There was a significant association between weight percentile and serum albumin and total protein (P=0.03 and P=0.007, respectively). There was also a significant relationship between height percentile and serum albumin and total protein (P<0.001 and P<0.000, respectively). The relationships between head circumference and serum albumin and total protein were also significant (P=0.006 and P<0.000, respectively). There was also a significant association between height percentile and hemoglobin. The decrease in anthropometric percentiles leads to decreased serum albumin and total protein.
Fallahi G, Najafi M, Farhmand F, et al. The clinical and laboratory manifestations of Iranian patients with cystic fibrosis. Turk J Pediatr 2010;52(2):132-8.
Farahmand F, Khalili M, Shahbaznejad L, et al. Clinical presentation of cystic fibrosis at the time of diagnosis: a multicenter study in a region without newborn screening. Turk J Gastroenterol 2013;24(6):541-5.
Motamed F, Fallahi G, Ahmadi F, et al. Gastroesophageal variceal bleeding as a complication of cystic fibrosis in a 3-month old patient. Acta Med Iran. 2016 2016;54(3):220-1.
Najafi M, Alimadadi H, Rouhani P, et al. Genotypephenotype relationship in Iranian patients with cystic fibrosis. Turk J Gastroenterol. 2015 May;26(3):241-3.
Mountinho CR, Chaves J, Augostiono De Britto, et al. Association between nutritional status measurements andpulmonary function in children and adolescents with cystic fibrosis. J Bras One mol 2009;35(5):409-14.
Peterson ML, Jacobs DR, Milla CE. Longitudinal changes in growth parameters are correlated with changes in pulmonary functions in children with cystic fibrosis. Pediatrics 2003;112(3 Pt 1):588-92.
Burdge GC, Goodate AJ, Hill CM, et al. Plasma lipidconcentrations in children with cystic fibrosis: the value of high-fat diet and pancreatic supplementation. Br J Nutr 1994;71(6):959-64.
Bentur L, Kalins D, Levison H, Corey M, et al. Dietary intakes of young children with cystic fibrosis: is there a difference? J Pediatr Gastroenterol Nutr 1996;22(3):254-8.
Lai Hc, Kosorok MR, Sondel SA, et al. Growth status in children with cystic fibrosis based on nutritional cystic fibrosis patient registry data: evaluation of various criteria used to identify malnutritional. J Pediatr 1998;132(3 Pt 1):478-85.
Shoff SM, Ahn HY, Davis L, Lai H. Wisconsin cystic fibrosis neonatal screening group. Temporal associationbetween energy intake, plasma linoleic acid and growth improvement in response to treatment initiation after diagnosis of cystic fibrosis. University of Wisconsin, USA 2006:117(2):391-400
Lai HJ, Shoff SM. Classification of malnutrition in cystic fibrosis: implications for evaluating and benchmarking clinical practice performance. Am J Clin Nutr 2008;88(1):161-6.
Gurrera IC, Astarita G, Jais JP, et al. A novel lipidomic strategy reveals plasma phospholipid signature associated with respiratory disease in cystic fibrosis patients. PLoS One 2009;4(11):e7735.
Ataee P, Najafi M, Gharagozlou M, et al. Effect of supplementary zinc on body mass index, pulmonary function and hospitalization in children with cystic fibrosis. Turk J Pediatr. 2014;56(2):127-32.
Laryea BB, Schuster A, Griese M, et al. Status of plasma and erythrocyte fatty acids and vitamin A and E in young children with cystic fibrosis. Scand J Gastroenterol suppl 1988;143:135-41.
Antony H, Bines J, Phelan P. Relationship between dietary intake and nutritional status in cystic fibrosis. Royal children’s Hospital. Arch Dis Child 1998;78(5):443-7.
De Boek K, Eggermont D, Veereman-Wauter G, et al. Lipid digestion in cystic fibrosis : comparison of conventional and high-lipase enzyme therapy using the mixed triglyceride breath test. J Pediatr Gastroenterol Nutr 1988;26(4):408-11.
Lepage G, Champagne J, Ronco N, et al.. Supplementation with carotenoids corrects increased lipid peroxidation in children with cystic fibrosis. Am J Clin Nutr 1996;64(1):87-93.
| Files | ||
| Issue | Vol 54, No 4 (2016) | |
| Section | Original Article(s) | |
| Keywords | ||
| Cystic fibrosis Growth Failure to thrive | ||
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