Original Article

Evaluation of Magnesium Levels in Serum and Cerebrospinal Fluid of Patients with Febrile Convulsion Hospitalized in Bahrami Hospital in Tehran in 2010-2011

Abstract

Evaluation of magnesium levels in serum and cerebrospinal fluid of patients with febrile convulsion (FC) hospitalized in Bahrami hospital in Tehran in 2010-2011. In the past, decreased levels of magnesium in serum and CSF of patients with FC were reported. The purpose of this study was to identify the possible role of magnesium in febrile seizures in children. Identifying this condition, we may control seizures and also prevent subsequent convulsion. In this cross-sectional study, inclusion criteria were the existence of convulsion due to fever and exclusion criteria were having a known neurological disease which could induce a seizure, and children younger than one month. In each group (cases include children with febrile convulsion and controls include febrile children without convulsion), Mg was measured in blood, and cerebrospinal fluid of 90 children and then they were compared. The data were analyzed by SPSS (α=0.05). The mean serum and CSF levels of Mg in case and control groups were equal (P<0.87 and P<0.22 respectively). There was no difference between two groups in terms of sex, but mean age was significantly different (P<0.003). There was not an association between serum and CSF levels of magnesium and the presence of FC. Therefore, it’s not suggested to measure the level of magnesium in serum or CSF in children with fever routinely.

Löscher W, Rating D, Siemes H. GABA in cerebrospinal fluid of children with febrile convulsions. Epilepsia 1981;22(6):697-702.

Burhanoğlu M, Tütüncüoğlu S, çoker C, et al. Hypozincaemia in febrile convulsion. Eur J Pediatr 1996;155(6):498-501.

Mollah AH, Dey R, Akhter S, et al. Zinc in CSF of patients with febrile convulsion. Indian J Pediatr 2002;69(10):859-61.

Leung A, Robson L. Febrile seizures. J Pediatr Health Care 2007;21(4):250-5.

Castilla-Guerra L, Del Carmen Fern´andez-Moreno M, L´opez-Chozas J, et al. Electrolytes Disturbances and Seizures. Epilepsia 2006;47(12):1990-8.

Prakash Mishra O, singhal D, Upadhyay R. S et al, Cerebro fluid zinc, magnesium, copper and gamma_aminobutyric acid levels in febrile seizures, J Pediatr Neurol 2007;5(1):39-44.

Evans D. Magnesium & Seizures. eHow. (Accessed in May 2015, 3, at http://www.ehow.com/about_6742961_magnesiumseizures.html).

Johnston M. Seizures in childhood. In: Kliegman R, Behrman R, Jenson H, et al, editors. Nelson Text book of pediatrics. 18th ed. Philadelphia: Saunders Elsevier; 2008: p. 2457.

Donaldson D, Trotman H, Barton M et al. Routin labortatoy investigations in infants and children presenting with fever and seizures at the university hospital of thebwest indies. West Indian Med J 2008;57(4):369-72.

Rutter N, Smales OR. Calcium, magnesium, and glucose= levels in blood and CSF of children with febrile convulsions. Arch Dis Child 1976;51(2):141-3.

Heipertz R, Eichoff K, karstens KH. Cerebrospinal fluid concentration of magnesium and inorganic phosphate in epilepsy. J Neurol Sci 1979;41(1):55-60.

Mroczkowska_Juchkiewicz A, Owska_kamieniak AP, Papier kowski A. Magnesium level in blood and cerebrospinal fluid of children with febril convulsions. Magnesium Research 2003;16(1):75-8.

Papierkowski A, Mroczkowska _Juchkiewicz A, Pawlowska _Kamieniak A, et al. Magnesium and zinc levels in blood serum and cerebrospinal fluid in children with febrile convulsions. Pol Merkur Lekarski 1999;6(33):138-40.

Chhaparwel BC, Kohl G, Pohawalla JN, et al. Magnesium levels in serum and in CSF in febrile convulsions in infants and children. Indian J Pediatr 1971;38(280):241-5.

Talebian A, Vakili Z, Talar S. A et al, Assessment of the relation between serum zinc & magnesium levels in children with febrile convulsion. Iranian J Pathol 2009;4(4):157-60.

Derakhshan R, Balaee P, Bakhshi H, et al. The relationship between serum magnesium level and febrile convulsion in 6 months to 6 years old children. ZJRMS 2010;12(2):40-2.

Sadi nejad M, Mohsenzadeh A, Varkoohi A, et al. Assessing serum magnesium level in 9months utill 5 years old children with febrile convulsion in spring 1383. J Iranian Children Dis 2002;13:00-00.

Files
IssueVol 53, No 12 (2015) QRcode
SectionOriginal Article(s)
Keywords
Febrile convulsion Serum magnesium Cerebrospinal fluid magnesium Children

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Khosroshahi N, Ghadirian L, Kamrani K. Evaluation of Magnesium Levels in Serum and Cerebrospinal Fluid of Patients with Febrile Convulsion Hospitalized in Bahrami Hospital in Tehran in 2010-2011. Acta Med Iran. 2015;53(12):778-781.