Traffic Noise Exposure Increases Gastric Pepsin Secretion in Rat
-
Azam Moslehi
,
Fatemeh Nabavizadeh
,
Mansoor Keshavarz
,
Nematollah Rouhbakhsh
,
Masoud Sotudeh
,
Ehsan Salimi
,
Amir Barzegar Behrooz
Abstract
Noise is considered as one of the most severe sources of environmental and workplace constraints. Many noise effects are well known on immune function, hormonal levels, cardiovascular and respiratory systems. In this study, our aim is to evaluate the effects of traffic noise exposure on basal and stimulated gastric pepsin secretion. 48 male rats were exposed to traffic noise (86 dB) for a short term of (8h/ day for 1 day) and a long term of (8h/ day for 7, 14, 21 and 28 days) as well as a control group. The gastric contents were collected by the wash-out technique. Pepsin secretion was measured by employing the Anson method. Histological studies were carried out on the epithelial layer. The corticosteroid hormone was measured in the serum for the stress augmentation. The present finding indicated no changes in pepsin secretion content in the short term, but in the 14 and 21 days traffic noise exposure, basal gastric pepsin secretion increased markedly compared to the control group. Histological results showed that the number of oxyntic glands and cell nuclei decreased in comparison with the control group while the thickness of the epithelial layer increases. In addition, the corticosterone levels increase in all groups in comparison with the control. It seems that the increase of gastric pepsin secretion is due to the description and translation processes in the peptic cells and needs enough time for completion.
Thomas N, Mariah AN, Fuad A, Kuljit S, Philip R. Noise exposure and noise induced hearing loss among Kuala Lumpur traffic point duty personnel. Med J Malaysia 2007; 62(2):152-5.
Zheng KC, Ariizumi M. Modulations of immune functions and oxidative status induced by noise stress. J Occup Health 2007; 49(1):32-8.
Armario A, Castellanos JM, Balasch J. Adaptation of anterior pituitary hormones to chronic noise stress in male rats. Behav Neural Biol 1984; 41(1):71-6.
Babisch W, Gallacher JE, Elwood PC. Traffic noise and cardiovascular risk. The Caerphilly study, first phase. Outdoor noise levels and risk factors. Arch Environ Health 1988; 43(6): 407-14.
Ising H, Lange-Asschenfeldt H, Lieber GF, et al. Respiratory and dermatological diseases in children with long-term exposure to road traffic emissions . Noise Health 2003; 5(19): 41-50.
Ising H, Lange-Asschenfeldt H, Moriske HJ, et al. Low frequency noise and stress: bronchitis and cortisol in children exposed chronically to traffic noise and exhaust fumes. Noise Health 2004; 6(23):21-8.
Gitanjali B, Ananth R. Effect of Acute Exposure to Loud Occupational Noise during Daytime on the Nocturnal Sleep Architecture, Heart Rate, and Cortisol Secretion in Healthy Volunteers. J Occup Health 2003; 4 5: 146-152.
Shiraishi T. Hypothalamic control of gastric acid secretion. Brain Res Bull 1988; 20(6):791-7.
Ganong WF. Regulation of Gastrointestinal Function. In: Ganong WF, eds. Review of Medical Physiology: Mc Graw Hill; 2005. P. 479-480.
Mu ZB, Huang YX, Zhao BM, Liu ZX, Zhang BH, Wang QL. Effect of explosive noise on gastrointestinal transit and plasma levels of polypeptide hormones. World J Gastroenterol 2006: 12(114): 2284-2287.
Tomei F, Papaleo B, Baccolo TP, et al. Noise and gastric secretion. Am J Ind Med 1994; 26(3):367-72.
Liu GS, Huang YX, Li SW, et al. Experimental study on mechanism and protection of stress ulcer produced by explosive noise. World J Gastroenterol 1998; 4(6): 519-523.
Blandizzi C, Bernardini MC, Natale G, et al. α2 Adrenoreceptor-mediated, inhibitory and excitory effects of detomidine on rat gastric acid secretion. J Pharm Pharmacol 1990; 42: 685–688.
Vera MN., Vila J, Godoy JF. Cardiovascular effects of traffic noise: the role of negative self-statements. Psychol Med 1994; 24(4):817-27.
Nabavizadeh FR, Maghuli F, Vahedian J, et al. The effects of chronic consumption of heroin on basal and vagal electrical-stimulated gastric acid and pepsin secretion in rat. Saudi Med J 2004; 25: 1356–1359
Nabavizadeh FR, Vahedian J. The effects of insulindependent diabetes mellitus on basal and distention-induced acid and pepsin secretion in rat. Diabetes Res Clin Pract 2004; 66:1–6.
Berstad A. A modified hemoglobin substrate method for the estimation of pepsin in gastric juice. Scand JGastroenterol 1970; 5: 343–348.
Kato S, Abe Y, Konishi M, et al. Mechanism of gastric hyperemic response during acid secretion in rats: relation to nitric oxide, prostaglandins and sensory neurons.
J Clin Gastroenterol 1997.25: S48–S55.
Spreng M. Central nervous system activation by noise. Noise Health 2000; 2(7); 49-58.
Babisch W. The Noise/Stress Concept, Risk Assessment and Research Needs. Noise Health 2002; 4(16):1-11.
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| Issue | Vol 54, No 3 (2016) | |
| Section | Original Article(s) | |
| Keywords | ||
| Traffic noise Gastric pepsin Rat Pentagastrin | ||
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