Sarcoid Myopathy Mimicking Polymyositis: A Case Report and Pool Analysis of the Literature Reviews

  • Syahrul Sazliyana Shaharir Mail Department of Internal Medicine, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.
  • Adawiyah Jamil Department of Internal Medicine, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.
  • Sumitro Kosasih Department of Internal Medicine, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.
  • Low Soo Fin Department of Radiology, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.
  • Radhika Sridharan Department of Radiology, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.
  • Suria Hayati Md Pauzi Department of Pathology, National University of Malaysia Medical Centre, Kuala Lumpur, Malaysia.
Keywords:
Granuloma, Myopathy, Sarcoidosis, Subcutaneous nodules

Abstract

A 59-year-old man presented with proximal myopathy, myalgia, and weight loss, with the initial markedly elevated serum creatine kinase at 11,000 U/L. Due to his refusal for muscle biopsy, he was initially treated as inflammatory myositis and responded well with the corticosteroids. However, he subsequently had a relapse of the symptoms with more extensive systemic involvement, i.e., hypercalcemia, lymphadenopathy and subcutaneous nodules. Finally, a biopsy of the thigh and subcutaneous nodule revealed non-caseating granulomatous inflammation, consistent with sarcoidosis. He responded well to the corticosteroids, and finally, azathioprine was added as a steroid-sparing agent. Including our series, there are 103 cases of symptomatic muscle involvement in sarcoidosis patients published in the English literature to date. Further pool analysis of the cases will be reported in this review.

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Published
2018-01-16
How to Cite
1.
Sazliyana Shaharir S, Jamil A, Kosasih S, Soo Fin L, Sridharan R, Hayati Md Pauzi S. Sarcoid Myopathy Mimicking Polymyositis: A Case Report and Pool Analysis of the Literature Reviews. Acta Med Iran. 55(12):800-806.
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