The Effect of Otic Melanocyte Destruction on Auditory and Vestibular Function: a Study on Vitiligo Patients
The hallmark of vitiligo is the disappearance of melanocytes from the skin. As a result, of melanocytes presence in the auditory and vestibular apparatus, the involvement of these systems in vitiligo which targets the melanocytes of the whole body is possible; suggesting that vitiligo is a systemic disease rather than a purely cutaneous problem. A total of 21 patients with vitiligo were enrolled in this study. A group of 20 healthy subjects served as a control group. Pure tone audiometry (PTA), auditory brainstem responses (ABR) and vestibular evoked myogenic potentials (VEMP) were carried out in all participants. High frequency sensory neural hearing loss was seen in 8 (38.09%) patients. ABR analysis revealed 10 (47.61%) had an abnormal increase in latency of wave III, and 6 (28.57%) had an abnormal prolongation of IPL I-III, however, regarding our VEMP findings, there were no recorded responses on left ear of 1 (4.76%) patient and latency of p13 was prolonged in 5(23.80%) patients. There was no correlation between ages, duration of disease, and any of the recorded parameters (P>0.05). In the present survey, we highlighted the auditory and vestibular involvement in vitiligo patients.
Abu TM, Pramod K, Ansari S, et al. Current remedies for vitiligo. Autoimmun Rev 2010;9(7):516.
Huggins RM, Schwartz RA, Janniger KC. Vitiligo. ActaDermatol 2005;14: 137-145.
Angrisani RM, Azevedo MF, Pereira LD, et al. A study on otoacoustic emission and suppression effects in patients with vitiligo. Braz J Otolaryngol 2009;75(1):111-5.
Aydogan K, Turan OF, Onart S, et al. Audiological abnormalities in patients with vitiligo. Clin Exp Dermatol 2006;31(1):110-3.
Borimnejad L, Yekta ZP, Nikbakht A. Lived Experience of Women Suffering from Vitiligo: A Phenomenological Study. Qual Rep 2006;11(2): 335-49.
Shajil EM, Chatterjee S, Agrawal D, et al. vitiligo: Pathomechanisms and genetic polymorphism of susceptible genes. Indian J Exp Biol 2006;44(7):526-39.
Nordlund JJ, Boissy RE, Hearing VJ, et al, editors. The pigmentary system: Physiology and pathophysiology. 2nd ed. Wiley-Blackwell; 2006: p. 91-107.
Aslan S, Serarslan G, Teksoz E, et al. Audiological and transient evoked otoacoustic emission findings in patientswith vitiligo. Otolaryngol Head Neck Surg 2010;142(3):409-14.
Ardie FN, Aktan S, Kara CO, et al. High-frequency hearing and reflex latency in patients with pigment disorder. Am J Otolaryngol 1998;19(6):365-9.
Colebatch JG, Halmagyi GM. Vestibular evoked potentials in human neck muscles before and after unilateral vestibular deafferentation. Neurology 1992;42(8):1635-6.
Pollak L, Kushnir M, Stryjer R. Diagnostic value of vestibular evoked myogenic potentials in cerebellar and lower-brainstem strokes. Clin Neurophysiol 2006;36(4):227-33.
American Speech Language-Hearing Association. Manual pure-tone threshold audiometry- ASHA 1978;20(4):221-7.
Murillo Cuesta S, Contreras J, Zurita E, et al. Melanin precursors prevent premature age related and noise induced hearing loss in albino mice. Pigm Cell Melanoma Res 2010;23(1):72-83.
Sharma L, Bhawan R, Jain RK. Hypoacoustic in vitiligo.Indian J Dermatol Venereol Leprol 2004;70(3):162-64.
Tosti A, Bardazzi F, Tosti G, et al. Audiologicabnormalities in cases of vitiligo. J Am Acta Dermatol 1987;17(2 Pt 1):230-3.
Sahrifian MR, Maleki M, Honarvar H. The correlation between vitiligo and hearing loss. Iran J Otorhinolaryngol 1986;17(42):3-8.
Orecchia G, Marelli MA, Fresa D, et al. Audiologic disturbances in vitiligo. J Am Acad Dermatol 1989;21(6): 1317-8.
El-Saied M, Naga A, Abdo IM. Evaluation of brain stem evoked response in vitiligo patients. J Pan-Arab League Dermatol 2008;19(1):91-7.
Shalaby MES, El-Zarea GA, Nassar AL. Auditiry function in vitiligo patients. Egypt Dermatol Online J 2006;2(1):7.
Wright CG, Lee DH. Pigmented cells of the stria vascularis and spiral ligament of the chinchilla. Acta Otolaryngol 1989;108(3-4):190-200.
Igarashi Y, Takeyama I, Takahashi I. Melanocytes in vestibular dark cell areas in human fetuses. Acta Otolaryngol 1989;108(1-2):9-18.
Wright CG, Lee DH. Pigmented epithelial cells of the membranous saccular wall of the chinchilla. Acta Otolaryngol 1986;102(5):438-49.
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