Is Serum Uric Acid Level Correlated with Erectile Dysfunction in Coronary Artery Disease Patients?
Abstract
Coronary artery disease (CAD) and vascular insufficiency are consequences of modern lifestyle, and vasogenic erectile dysfunction (ED) is one of the leading causes of sexual dysfunction which could be prevented like ischemic heart disease if the risk factors are discovered and managed. Seventy-five men scheduled for coronary angiography were asked to fill out the IIEF5 questionnaire and underwent serum lipoprotein-a, uric acid, lipid profile, testosterone, Sex Hormone Binding Globulin (SHBG), dehyderoepiandrostendion sulfate (DHEAS) tests; and the results were compared with those of erectile dysfunction patients with and without coronary artery disease. Ten out of 32 CAD patients (30%) and 6 of 43 normal coronary men had ED Prevalence (P=0.04). The average serum uric acid in ED patients with normal coronary was 5.6 (± 0.68) 6.5 ±078 mg/dl in ED patients of CAD group P=0.034. Men with both ED and CAD had significantly higher levels of lipoprotein-a compared to those CAD patients with normal sexual function. Higher uric acid and lipoprotein-a levels are correlated with the presence of ED in patients with CAD.
Shabsigh R, Kaufman J, Magee M, et al. Lack of awareness of erectile dysfunction in many men with risk factors for erectile dysfunction. BMC Urol 2010;10(1):18.
Kawanishi Y, Lee KS, Kimura K, et al. Screening for ischemic heart disease with cavernous artery blood flow in erectile dysfunctional patients. Int J Impot Res 2001;13(2):100-3.
Feldman HA, Johannes CB, Derby CA, et al. Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts male aging study. Prev Med 2000;30(4):328-38.
Corona G, Maggi M. Conventional and unconventional cardiovascular risk factors in men with erectile dysfunction. J Sex Med 2013;10(2):305-8.
Brodov Y, Chouraqui P, Goldenberg I, et al. Serum uric acid for risk stratification of patients with coronary artery disease. Cardiology 2009;114(4):300-5.
Jelić-Ivanović Z, Memon L, Spasojević-Kalimanovska V, et al. Independent association of high serum uric acid concentration with angiographically defined coronaryartery disease. Tohoku J Exp Med 2007;211(4):369-77.
Nehra A. Erectile dysfunction and cardiovascular disease: efficacy and safety of phosphodiesterase type 5 inhibitors in men with both conditions. Mayo Clin Proc 2009;84(2):139-48.
Kaya EB, Yorgun H, Canpolat U, et al. Serum uric acid levels predict the severity and morphology of coronary atherosclerosis detected by multidetector computedtomography. Atherosclerosis 2010;213(1):178-83.
Kanbay M, Sanchez-Lozada LG, Franco M, et al. Microvascular disease and its role in the brain and cardiovascularsystem: A potential role for uric acid as a cardiorenal toxin. Nephrol Dial Transplant 2011;26(2):430-7.
Lin CS, Hung YJ, Chen GY, et al. A multicenter study of the association of serum uric acid, serum creatinine, and diuretic use in hypertensive patients. Int J Cardiol 2011;148(3):325-30.
Rodrigues TC, Maahs DM, Johnson RJ, et al. Serum uricacid predicts progression of subclinical coronary atherosclerosis in individuals without renal disease. Diabetes Care 2010;33(11):2471-3.
Justo D, Arbel Y, Mulat B, et al. Sexual activity and erectile dysfunction in elderly men with angiographically documented coronary artery disease. Int J Impot Res 2009;22(1):40-4.
Sinan Deveci O, Kabakci G, Okutucu S, et al. The association between serum uric acid level and coronary artery disease. Int J Clin Pract 2010;64(7):900-7.
Jackson G, Boon N, Eardley I, et al. Erectile dysfunction and coronary artery disease prediction: evidencebased guidance and consensus. Int J Clin Practe2010;64(7):848-57.
Meluzín J, Vasků A, Kincl V, et al. Association of coronary artery disease, erectile dysfunction, and endothelial nitric oxide synthase polymorphisms. Heart Vessels 2009;24(3):157-63
Kincl V, Panovsky R, Meluzin J, et al. Association between laboratory markers and presence of coronary artery disease. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2010;154(3):227-33.
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Issue | Vol 54, No 3 (2016) | |
Section | Original Articles | |
Keywords | ||
Cronary artery disease Erectile dysfunction Uric acid |
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