Association of Lipid Accumulation Product with Cardio-Metabolic Risk Factors in Postmenopausal Women


The lipid accumulation product is a novel, safe and inexpensive index of central lipid over accumulation based on waist circumference and fasting concentration of circulating triglycerides. This study was designed to investigate the ability of lipid accumulation product to predict Cardio-metabolic risk factors in postmenopausal women. In this Cross-sectional study, 264 postmenopausal women by using convenience sampling method were selected from menopause clinic in Tehran. Cardio-metabolic risk factors were measured, and lipid accumulation product (waist-58×triglycerides [nmol/L]) was calculated. Optimal cut-off point of lipid accumulation product for predicting metabolic syndrome was estimated by ROC (Receiver-operating characteristic) curve analysis. Metabolic syndrome was diagnosed in 41.2% of subjects. Optimal cut-off point of lipid accumulation product for predicting metabolic syndrome was 47.63 (sensitivity:75%; specificity:77.9%). High lipid accumulation product increases risk of all Cardio-metabolic risk factors except overweight, high Total Cholesterol, high Low Density Lipoprotein Cholesterol and high Fasting Blood Sugar in postmenopausal women. Our findings show that lipid accumulation product is associated with metabolic syndrome and some Cardio-metabolic risk factors Also lipid accumulation product may have been a useful tool for predicting cardiovascular disease and metabolic syndrome risk in postmenopausal women.

Douchi T, Yamamoto S, Nakamura S, Ijuin T, Oki T, Maruta K, et al. The effect of menopause on regional and total body lean mass. Maturitas 1998;29:247-52.

Toth M, Tchernof A, Sites C, Poehlman ET. Effect of menopausal status on body composition and abdominal fat distribution. Int J Obes Relat Metab Disord 2000;24:226-31.

Prineas RJ, Folsom AR, Kaye SA. Central adiposity and increased risk of coronary artery disease mortality in older women. Ann Epidemiol 1993;3:35-41.

Expert Panel on Detection Evaluation THBCA. Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). JAMA 2001;285:2486-97.

Austin MA, Hokanson JE, Edwards KL. Hypertriglyceridemia as a cardiovascular risk factor. Am JCardiol 1998;81:7B-12B.

Kahn HS. The "lipid accumulation product" performsbetter than the body mass index for recognizing cardiovascular risk: a population-based comparison. BMCCardiovasc Disord 2005;5:26.

Wiltgen D, Benedetto I, Mastella L, Spritzer PM. Lipid accumulation product index: a reliable marker of cardiovascular risk in polycystic ovary syndrome. Hum Reprod 2009;24:1726-31.

Wehr E, Pilz S, Boehm BO, März W, Obermayer-Pietsch B. The lipid accumulation product is associated with increased mortality in normal weight postmenopausal women. Obesity 2011;19:1873-80.

Perkins NJ, Schisterman EF. The inconsistency of “optimal” cutpoints obtained using two criteria based on the receiver operating characteristic curve. Am J Epidemiol 2006;163:670-5.

Zweig MH, Campbell G. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinicalmedicine. Clin Chem 1993;39:561-77.

Maturana MA, Moreira R, Spritzer PM. Lipid accumulation product (LAP) is related to androgenicity and cardiovascular risk factors in postmenopausal women. Maturitas 2011;70:395-9.

Després JP, Lemieux I, Bergeron J, Pibarot P, Mathieu P, Larose E, et al. Abdominal obesity and the metabolicsyndrome: contribution to global cardiometabolic risk.Arterioscler Thromb Vasc Biol 2008;28:1039-49.

Ejike C. Lipid accumulation product and waist-to-height ratio are predictors of the metabolic syndrome in a Nigerian male geriatric population. J Rural Trop Public Health 2011;10:101-5.

Kahn HS, Valdez R. Metabolic risks identified by the combination of enlarged waist and elevated triacylglycerol concentration. Am J Clin Nutr 2003;78:928-34.

Siani A, Cappuccio FP, Barba G, Trevisan M, FarinaroE, Lacone R, et al. The relationship of waist circumference to blood pressure: the Olivetti Heart Study. Am J Hypertens 2002;15:780-6.

Schneider HJ, Glaesmer H, Klotsche J, Böhler S, Lehnert H, Zeiher AM, et al. Accuracy of anthropometric indicators of obesity to predict cardiovascular risk. J Clin Endocrinol Metab 2007;92:589-94.

Esmaillzadeh A, Mirmiran P, Azizi F. Comparative evaluation of anthropometric measures to predict cardiovascular risk factors in Tehranian adult women. Public Health Nutr 2006;9:61-9.

Taverna MJ, Martínez-Larrad MT, Serrano-Ríos M. Lipid accumulation product: a powerful marker of metabolic syndrome in healthy population. Eur J Endocrinol .

Tankó LB, Bagger YZ, Qin G, Alexandersen P, Larsen PJ, Christiansen C. Enlarged waist combined with elevated triglycerides is a strong predictor of accelerated atherogenesis and related cardiovascular mortality in postmenopausal women. Circulation 2005;111:1883-90.

Achie L, Olorunshola K, Toryila J, tende JA. The Body Mass Index, Waist Circumference and Blood Pressure of Postmenopausal Women in Zaria, Northern Nigeria. Curr Res J Biol Sci 2012;4:329-32.

Donato GB, Fuchs SC, Oppermann K, Bastos C, Spritzer PM. Association between menopause status and central adiposity measured at different cutoffs of waistcircumference and waist-to-hip ratio. Menopause 2006;13:280-5.

Wehr E, Gruber HJ, Giuliani A, Möller R, Pieber TR, Obermayer-Pietsch B. The lipid accumulation product is associated with impaired glucose tolerance in PCOS women. J Clin Endocrinol Metab 2011;96:E986-90.

IssueVol 54, No 6 (2016) QRcode
Lipid accumulation product Menopause Metabolic syndrome Cardio-metabolic syndrome

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
Namazi Shabestari A, Asadi M, Jouyandeh Z, Qorbani M, Kelishadi R. Association of Lipid Accumulation Product with Cardio-Metabolic Risk Factors in Postmenopausal Women. Acta Med Iran. 2016;54(6):370-375.