Acetaminophen Versus Liquefied Ibuprofen for Control of Pain During Separation in Orthodontic Patients: A Randomized Triple Blinded Clinical Trial
The aim of this randomized clinical study was to investigate the effectiveness of acetaminophen 650 mg or liquefied ibuprofen 400 mg in pain control of orthodontic patients during separation with an elastic separator. A total of 101 patients with specific inclusion criteria were divided randomly into three groups (acetaminophen, liquefied ibuprofen, and placebo). They were instructed to take their drugs one hour before separator placement and every six hours afterward (five doses in total). They recorded their discomfort on visual analog scales immediately after separator placement, 2 hours later, 6 hours later, at bedtime, and 24 hours after separator placement. Repeated measure analysis of variance (ANOVA) was used to compare the mean pain scores between the three groups. Data were collected from 89 patients. The pain increased with time in all groups. Pain scores were statistically lower in the analgesic groups compared with the placebo group (P.value<0.001), but no statistically significant difference was found in mean pain scores between the two drug groups (acetaminophen and liquefied ibuprofen) (P.value=1). Acetaminophen and liquefied ibuprofen have similar potential in pain reduction during separation.
Hacopian N, Hosseinzadeh Nik T, Ghahremani MH, Rahimi HR, Ostad SN. Effects of Continuous and Interrupted Forces on Gene Transcription in Periodontal Ligament Cells in Vitro. Acta Med Iran 2011;49:643-9.
Scheurer PA, Firestone AR, Burgin WB. Perception of Pain as a result of orthodontic treatment with fixed appliances. Eur J Orthod 1996;18:349-57.
Oliver RG, Knapman YM. Attitudes to orthodontic treatment. Br J Orthod 1985;12:179-88.
Polat O, Karaman AI. Pain control during fixed orthodontic appliance therapy. Angle Orthod 2005;75:214-9.
Negan P, Wilson S, Shanfeld J. The effect of ibuprofen and the level of discomfort in Patients undergoing orthodontic treatment. Am J Orthod dentofacial Orthop 1994;106:88-95.
Steen Law SL, Southard KA, Law AS. An evaluation of Preoperative ibuprofen for treatment of pain associated with orthodontic Separator Placement. Am J Orthod Dentofacial Orthop 2000;118:629-35.
Bird S, Williams K, Kula K. Preoperative acetaminophen vs ibuprofen for control of Pain after orthodontic Separator Placement. Am J Orthod Dentofacial Orthop 2007;132:505-10.
Bradley RL, Tomas P. A randomized clinical trial comparing the efficacy of ibuprofen and paracetamol in control of orthodontic pain. Am J Orthod Dentofacial Orthop 2007;132:511-17.
Hoffman WE. A study of 4 types of orthodontic separator.Am J Orthod 1972;62:68-73.
Nalbantgil D, Cakan DG, Oztoprak MO, et al. Perception of pain and discomfort during tooth separation. Aust Orthod J 2009;25:110-5.
Okeson JP, editor. Bell's Orofacial Pain. 5th ed. Carol Stream, Ill: Quintessence Publishing Co Inc, 1995:79-84.
Jones M, Chan C. The pain and discomfort experienced during orthodontic treatment. A randomized controlled trial of two aligning arch wires. Am J Orthod Dentofacial Orthop 1992;102:373-81.
Fernandes LM, Ogaard B, Skoglund L. Pain and discomfort experienced after placement of a conventional or a super elastic NiTi aligning archwire. A randomized clinical trial. J Orofac Orthop 1998;59:331-9.
Minor V, Marris CK, Mc Gorray SP, et al. Effects of preoperative ibuprofen on pain after separator placement. Am J Orthod Dentofacial Orthop 2009;136:510-7.
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