Case Report

Extramedullary Plasmacytoma of the Breast: A Case Report and Literature Review


Breast plasmacytoma is a rare neoplasm. Here we present a case of extramedullary plasmacytoma of the breast in a 41-year-old Iranian lady who was a known case of spine plasmacytoma. Two years ago study case was presented with severe back pain. At that time, MRI revealed an expansile and destructive lesion in the body of S1 which was suggestive of metastasis. The patient underwent incisional biopsy that was a representative of a plasmacytoma. Skeletal survey, bone marrow aspiration, and serum protein electrophoresis were negative. The patient received radiation therapy. This year (2 years later) she detected a mass in her right breast. A mammography revealed a 30 mm high-density mass with an ill-defined border in the right breast. The mass was excised, and histological examination confirmed the diagnosis of plasmacytoma. Although plasmacytoma of the breast is rare, this tumor should be considered as a differential diagnosis of a breast mass, especially in patients with plasma cell dyscrasias.

Kalyani A, Rohaizak M, Cheong SK, Nor Aini U, Balasundaram V, Norlia A. Recurrent multiple myeloma presenting as a breast plasmacytoma. Med J Malaysia 2010; 65: 227-228.

Taylor L, Aziz M, Klein P, Mazumder A, Jagannath S, Axelrod D. Plasmacytoma in the breast with axillary lymph node involvement: a case report. Clin Breast Cancer 2006; 7: 81-84.

Pasquini E, Rinaldi P, Nicolini M, Papi M, Fabbri P, Bernardi L, et al. breast involvement in immunolymphoproliferative disorders; a report of two cases of multiple myeloma of the breast. Ann Oncol 2000; 11: 1153-9.

Surov A, Holzhausen HJ, Ruschke K, Arnold D, Spielmann RP. Breast plasmacytoma. Acta Radiol 2010; 51:498–504.

Blade J, Kyle RA, Greipp PR. Presenting features and prognosis in 72 patients with multiple myeloma who were younger than 40 years. Br J Haematol 1996; 93(2):345–51.

Lorsbach RB, Hsi ED, Dogan A, Fend F. Plasma cell myeloma and related neoplasms. Am J Clin Pathol 2011; 136(2):168–82

Lamy O, von Bremen K, Burckhardt P. Breast plasmacytoma. Leukemia Lymphoma 2000; 37:611 - 15.

Khalbuss WE, Fisher G, Ahmad M, Villas B. Synchronous presentation of breast carcinoma with plasmocytoid cytomorphology and multiple myeloma. Breast J 2006;12:165-7.

De Chiara A, Losito S, Terracciano L, Di Giacomo R, Iaccarino G, Rubolotta MR. Primary Plasmacytoma of the Breast. Arch Pathol Lab Med 2001; 125 (8): 1078-1080

Kaviani A, Djamali-zavareie M, Noparast M, Keyhani-Rofagha S. Recurrence of primary extramedullary plasmacytoma in breast both simulating primary breast carcinoma. World J Surgical Oncol 2004; 2:29.

IssueVol 56, No 3 (2018) QRcode
SectionCase Report(s)
Plasmacytoma Breast Extramedullary

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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
Binesh F, Vahedian HA, Shabani M, Zare S, Shahcheraghi SH. Extramedullary Plasmacytoma of the Breast: A Case Report and Literature Review. Acta Med Iran. 56(3):204-207.