Gastrointestinal Manifestations in a Child With Mastocytosis
-
Gholamhossein Fallahi
,
Parisa Rashtian
,
Majid Aflatounian
,
Nazanin Babaei
,
Mehdi Gaisari
,
Nima Rezaei
Abstract
Mastocytosis is characterized by the accumulation of mast cells in different tissues either in the skin or extracutaneous organs. Herein, a 13-year-old girl is presented who suffered from intermittent abdominal pain, nausea, diarrhea with erythematous, and papulous cutaneous lesion. She had a history of same lesions from the age of four years. Since 8 months ago, the patient presented with digestive complaints. The histopathological examination of the cutaneous lesions approved the diagnosis of mastocytosis. H1 and H2 antagonists were prescribed for her, while a mast cell stabilizer for digestive and cutaneous symptoms was also utilized, which improved the signs and symptoms of the patient.
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10. Ammannagari N, Grethlein S, Longhi JJ, Fisk JM. k. Isolated splenomegaly as the only presentation of systemic mastocytosis. Ann Hematol 2013;92:1573-5.
11. Valent P, Akin C, Sperr WR, Escribano L, Arock M, Horny HP, et al. Aggressive systemic mastocytosis and related mast cell disorders: current treatment options and proposed response criteria. Leuk Res 2003;27:635-41.
2. Shields HM, Shaffer K, O’Farrell RP, Travers R, Hayward JN, Becker LS, et al. Gastrointestinal Manifestations of Dermatologic Disorders. Clin Gastroenterol Hepatol 2007;5:1010-7.
3. Georgescu EF, Stănescu L, Georgescu CV, Georgescu I. Type Ib indolent mastocytosis with systemic involvement: cutaneous mastocytosis and gastrointestinal involvement at young girl. Rom J Morphol Embryol 2008;49:547-52.
4. Mickys U, Barakauskiene A, De Wolf-Peeters C, Geboes K, De Hertogh G. Aggressive systemic mastocytosis complicated by protein-losing enteropathy. Dig Liver Dis
2007;39:693-7.
5. Elvevi A, Grifoni F, Branchi F, Gianelli U, Conte D. Severe chronic diarrhea and maculopapular rash: A case report. World J Gastroenterol 2011;17:3948-52.
6. Lee JK, Whittaker SJ, Enns RA, Zetler P. Gastrointestinal manifestations of systemic mastocytosis. World J Gastroenterol 2008;14:7005-8.
7. A Akbar S, Raza S, E Denney J, J Johannesen E, C Doll D. Systemic Mastocytosis Presenting as Acute Appendicitis: A Case Report and Review of the Literature. Case Rep Oncol 2013;6:174-9,
8. Valent P. Review Article: Mastocytosis: a paradigmatic example of a rare disease with complex biology and pathology. Am J Cancer Res 2013;3:159-72.
9. Ramsay DB, Stephen S, Borum M, Voltaggio L, Doman DB. Mast Cells in Gastrointestinal Disease. Gastroenterol Hepatol 2010;6:772-7.
10. Ammannagari N, Grethlein S, Longhi JJ, Fisk JM. k. Isolated splenomegaly as the only presentation of systemic mastocytosis. Ann Hematol 2013;92:1573-5.
11. Valent P, Akin C, Sperr WR, Escribano L, Arock M, Horny HP, et al. Aggressive systemic mastocytosis and related mast cell disorders: current treatment options and proposed response criteria. Leuk Res 2003;27:635-41.
| Files | ||
| Issue | Vol 56, No 10 (2018) | |
| Section | Case Report(s) | |
| Keywords | ||
| Gastrointestinal manifestations Child Mastocytosis | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Fallahi G, Rashtian P, Aflatounian M, Babaei N, Gaisari M, Rezaei N. Gastrointestinal Manifestations in a Child With Mastocytosis. Acta Med Iran. 2019;56(10):684-687.
