Histiocytic Sarcoma of Nasal Cavity: A Case Report
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Abstract
Histiocytic sarcoma is a rare hematopoietic malignancy that originates from histiocytes, and may involve lymph nodes and extranodal sites such as the spleen, head and neck, skeleton, liver, breast, bone marrow, mediastinum, pancreas, skin, lung, kidney, central nervous system, testis, gastrointestinal tract, and uterus. The involvement of the nasal cavity is considered extremely rare. The prognosis is poor, even with chemotherapy, and the survival time is usually two years. We report the case of a 16-year-old-male with primary histiocytic sarcoma of the nasal cavity. The diagnosis was based on classical histopathology and immunohistochemical findings. This malignancy has not shown consistent satisfactory responses to chemotherapy regimens.
García-Gutiérrez M, Ortiz-Hidalgo C. [Histiocytic sarcoma. Diagnostic histopathologic and immunohitochemical criteria and the differential diagnosis.] GAMO 2011;10(6):373-83.
Hornick JL, Jaffe ES, Fletcher CD. Extranodal histiocytic sarcoma: clinicopathologic analysis of 14 cases of a rare epithelioid malignancy. Am J Surg Pathol 2004;28(9):1133-44.
Narita K, Noro R, Seike M, Matsumoto M, Fujita K, Matsumura J, et al. Successful treatment of histiocytic sarcoma and concurrent HIV infection using a combination of CHOP and antiretroviral therapy. Intern Med 2013;52(24):2805-9.
Takahashi E, Nakamura S. Histiocytic sarcoma: an updated literature review based on the 2008 WHO classification. J Clin Exp Hematop 2013;53(1):1-8.
Vos JA, Abboncanzo SL, Barekman CL, Andriko JW, Miettinen M, Aguilera NS. Histiocytic sarcoma: a study of five cases including the histiocyte marker CD163. Modern Pathol 2005;18(5):693-704.
Yoshida C, Takeuchi M. Histiocytic sarcoma: Identification of its histiocytic origin using immunohistochemistry. Intern Med 2008;47(3):165-9.
Agarwal A, Pathak S, Gujral S. Sinus histiocytosis with massive lymphadenopathy – a review of seven cases. Indian J Pathol Microbiol 2006;49(4):509-15.
Mainard C, D’Amore ES, Pillon M, Toffolutti T, Rosolen A. A case of resistant pediatric histiocytic sarcoma successfully treated with chemo-radiotherapy and autologous peripheral blood stem cell transplant. Leuk Lymphoma 2011;52(7):1367-71.
Buonocore S, Valente AL, Nightingale D, Bogart J, Souid AK. Histiocytic sarcoma in a 3-year-old male: A case report. Pediatrics 2005;116(2):e322-5.
| Files | ||
| Issue | Vol 56, No 11 (2018) | |
| Section | Case Report(s) | |
| Keywords | ||
| Nasal cavity Immunohistochemistry Chemotherapy Histiocytic sarcoma | ||
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