Lithium Decreases Streptozocin-Induced Diabetic Neuropathy in Rats by Inhibiting of Adenosine Triphosphate (ATP) Degradation
-
Azar Aghazadeh Khasraghi
,
Maryam Baeeri
,
Borna Payandemehr
,
Mahshid Rezaeiroushan
,
Gelareh Vakilzadeh
,
Shokoufeh Hassani
,
Asieh Hosseini
,
Gholamreza Hassanzadeh
,
Ahmad Reza Dehpour
,
Mohammad Sharifzadeh
Abstract
One of the most frequent complications of diabetes is diabetic peripheral neuropathy. Hyperglycemia would result in the advancement of this condition over a period of time. The most effective way in preventing diabetic neuropathy is regular control of glucose. In this study; we evaluated the effects of lithium onstreptozocin (STZ)-induced diabetic neuropathy in rats. Diabetic neuropathy was created 7 weeks after administration of STZ (45 mg/kg). Lithium was added to drinking water (450 mg/l) for 7 weeks and its plasma level after this period of time was 0.17±0.02 mmol/l. Levels of adenosine triphosphate (ATP) in dorsal root ganglion (DRG) neurons, oxidative stress parameters, open-field activity test and morphological analysis were assessed in this investigation. Currentresults showed significant elevation of oxidative stress biomarkers, reduction of ATP, abnormal morphology of DRG neurons and decrease of total distance moved in rats with STZ-induced diabetic neuropathy. The alterations in mentioned parameters were considerably restored by lithium treatment. These findings provide evidence for protective effects of lithium on STZ-induced diabetic neuropathy.
Zenker J, Ziegler D, Chrast R. Novel pathogenic pathways in diabetic neuropathy. Trends in neurosciences 2013;36:439-49.
Edwards JL, Vincent AM, Cheng HT, Feldman EL. Diabetic neuropathy: mechanisms to management. Pharmacology & therapeutics 2008;120:1-34.
Feldman EL. Oxidative stress and diabetic neuropathy: a new understanding of an old problem. Journal of Clinical Investigation 2003;111:431.
Obrosova IG. Update on the pathogenesis of diabetic neuropathy. Current diabetes reports 2003;3:439-45.
Sima A, Sugimoto K. Experimental diabetic neuropathy: an update. Diabetologia 1999;42:773-88.
Sytze van Dam P. Oxidative stress and diabetic neuropathy: pathophysiological mechanisms and treatment perspectives. Diabetes/metabolism research and reviews 2002;18:176-84.
Vincent AM, Russell JW, Low P, Feldman EL. Oxidative stress in the pathogenesis of diabetic neuropathy. Endocrine reviews 2004;25:612-28.
Shimizu T, Shibata M, Wakisaka S, Inoue T, Mashimo T, Yoshiya I. Intrathecal lithium reduces neuropathic pain responses in a rat model of peripheral neuropathy. Pain 2000;85:59-64.
Camins A, Verdaguer E, Junyent F, Yeste‐Velasco M, Pelegrí C, Vilaplana J, et al. Potential mechanisms involved in the prevention of neurodegenerative diseases by lithium. CNS neuroscience & therapeutics 2009;15:333-44.
Caldero J, Brunet N, Tarabal O, Piedrafita L, Hereu M, Ayala V, et al. Lithium prevents excitotoxic cell death of motoneurons in organotypic slice cultures of spinal cord. Neuroscience 2010;165:1353-69.
Makoukji J, Belle M, Meffre D, Stassart R, Grenier J, Fledrich R, et al. Lithium enhances remyelination of peripheral nerves. Proceedings of the National Academy of Sciences 2012;109:3973-8.
Chiu CT, Chuang DM. Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders. Pharmacology & therapeutics 2010;128:281-304.
Yu F, Wang Z, Tchantchou F, Chiu C-T, Zhang Y, Chuang D-M. Lithium ameliorates neurodegeneration, suppresses neuroinflammation, and improves behavioral performance in a mouse model of traumatic brain injury. Journal of neurotrauma 2012;29:362-74.
Hosseini A, Sharifzadeh M, Rezayat SM, Hassanzadeh G, Hassani S, Baeeri M, et al. Benefit of magnesium-25 carrying porphyrin-fullerene nanoparticles in experimental diabetic neuropathy. International journal of nanomedicine 2010;5:517.
Kei S. Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method. Clinica chimica acta 1978;90:37-43.
Hu M, Dillard C. Plasma SH and GSH measurement. Methods Enzymol 1994;233:87.
Pakzad M, Fouladdel S, Nili-Ahmadabadi A, Pourkhalili N, Baeeri M, Azizi E, et al. Sublethal exposures of diazinon alters glucose homostasis in Wistar rats: biochemical and molecular evidences of oxidative stress in adipose tissues. Pesticide biochemistry and physiology 2013;105:57-61.
Hosseini A, Abdollahi M, Hassanzadeh G, Rezayat M, Hassani S, Pourkhalili N, et al. Protective Effect of Magnesium‐25 Carrying Porphyrin‐Fullerene Nanoparticles on Degeneration of Dorsal Root Ganglion Neurons and Motor Function in Experimental Diabetic Neuropathy. Basic & clinical pharmacology & toxicology 2011;109:381-6.
Negi G, Kumar A, Kaundal RK, Gulati A, Sharma SS. Functional and biochemical evidence indicating beneficial effect of Melatonin and Nicotinamide alone and in combination in experimental diabetic neuropathy. Neuropharmacology 2010;58:585-92.
Visnagri A, Kandhare AD, Kumar VS, Rajmane AR, Mohammad A, Ghosh P, et al. Elucidation of ameliorative effect of co-enzyme Q10 in streptozotocin-induced diabetic neuropathic perturbation by modulation of electrophysiological, biochemical and behavioral markers. Biomedicine & Aging Pathology 2012;2:157-72.
Zangiabadi N, Asadi-Shekaari M, Sheibani V, Jafari M, Shabani M, Asadi AR, et al. Date fruit extract is a neuroprotective agent in diabetic peripheral neuropathy in streptozotocin-induced diabetic rats: a multimodal analysis. Oxidative medicine and cellular longevity 2011;2011.
Machado‐Vieira R, Manji HK, Zarate Jr CA. The role of lithium in the treatment of bipolar disorder: convergent evidence for neurotrophic effects as a unifying hypothesis. Bipolar disorders 2009;11:92-109.
Wada A, Yokoo H, Yanagita T, Kobayashi H. Lithium: potential therapeutics against acute brain injuries and chronic neurodegenerative diseases. Journal of pharmacological sciences 2005;99:307-21.
Pourmohammadi N, Alimoradi H, Mehr SE, Hassanzadeh G, Hadian MR, Sharifzadeh M, et al. Lithium attenuates peripheral neuropathy induced by paclitaxel in rats. Basic & clinical pharmacology & toxicology 2012;110:231-7.
Edwards J, Quattrini A, Lentz S, Figueroa-Romero C, Cerri F, Backus C, et al. Diabetes regulates mitochondrial biogenesis and fission in mouse neurons. Diabetologia 2010;53:160-9.
Vincent AM, Brownlee M, Russell JW. Oxidative stress and programmed cell death in diabetic neuropathy. Annals of the New York Academy of Sciences 2002;959:368-83.
Aminzadeh A, Dehpour AR, Safa M, Mirzamohammadi S, Sharifi AM. Investigating the Protective Effect of Lithium Against High Glucose-Induced Neurotoxicity in PC12 Cells: Involvements of ROS, JNK and P38 MAPKs, and Apoptotic Mitochondria Pathway. Cellular and molecular neurobiology 2014.
Chiu C-T, Chuang D-M. Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders. Pharmacology & therapeutics 2010;128:281-304.
Zangiabadi N, Sheibani V, Asadi-Shekaari M, Shabani M, Jafari M, Asadi A, et al. Effects of melatonin in prevention of neuropathy in STZ-induced diabetic rats. Am J Pharmacol Toxicol 2011;6:59-67.
Forlenza OV, De-Paula VdJR, Diniz B. Neuroprotective effects of lithium: implications for the treatment of Alzheimer’s disease and related neurodegenerative disorders. ACS chemical neuroscience 2014;5:443-50.
Rossetti L. Normalization of insulin sensitivity with lithium in diabetic rats. Diabetes 1989;38:648-52.
Wang XQ, Xiao AY, Sheline C, Hyrc K, Yang A, Goldberg MP, et al. Apoptotic insults impair Na+, K+-ATPase activity as a mechanism of neuronal death mediated by concurrent ATP deficiency and oxidant stress. Journal of Cell Science 2003;116:2099-110.
Kamboj SS, Vasishta RK, Sandhir R. N‐acetylcysteine inhibits hyperglycemia‐induced oxidative stress and apoptosis markers in diabetic neuropathy. Journal of neurochemistry 2010;112:77-91.
Banerjee U, Dasgupta A, Rout JK, Singh OP. Effects of lithium therapy on Na+–K+-ATPase activity and lipid peroxidation in bipolar disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2012;37:56-61.
Kishi M, Tanabe J, Schmelzer JD, Low PA. Morphometry of dorsal root ganglion in chronic experimental diabetic neuropathy. Diabetes 2002;51:819-24.
| Files | ||
| Issue | Vol 56, No 3 (2018) | |
| Section | Original Article(s) | |
| Keywords | ||
| Diabetic peripheral neuropathy Streptozocin Lithium Oxidative stress Dorsal root ganglion neurons Motor function | ||
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