A Case of Mitral Valve Metastasis From Breast Carcinoma Mimicking as a Mitral Valve Regurgitation
Abstract
Metastatic involvement of cardiac valve and pericardium mimicking a cardiac valve pathology accompanied with cardiac tamponade is a rare phenomenon. These metastases commonly arise from the lymphoreticular system, the pulmonary system, and breast. Metastatic spread of breast carcinoma to the cardiac valve is exceedingly rare, and only two case reports have been detected in English literature so far. We report a rare case of a patient with adenocarcinoma of the breast, which presented with severe mitral valve regurgitation and pericardial effusion which was managed urgently with mitral valve replacement. Our case shows the probability of combined metastatic pericardial and valve involvement in patients with breast adenocarcinoma. The patient was treated with mitral valve replacement and intrapericardial infusion of cisplatinum drug to control possible recurrent effusion.
Reynen K: Frequency of primary tumors of the heart. Am J Cardiol. 1996, 77: 107-10.1016/S0002-9149(97)89149-7.View ArticlePubMedGoogle Scholar
Burke A, Virmani R: Tumors of the Cardiovascular System, Atlas of Tumor Pathology. 1996, Washington, DC: Armed Forces Institute of PathologyGoogle Scholar
Klatt EC, Heitz DR: Cardiac metastases. Cancer. 1990, 65: 1456-1459. 10.1002/1097-0142(19900315)65:6<1456::AID-CNCR2820650634>3.0.CO;2-5.View ArticlePubMedGoogle Scholar
Chiles C, Woodard PK, Gutierrez FR, Link KM: Metastatic involvement of the heart and pericardium: CT and MR imaging. Radiographics. 2000, 20: 1073-1103.View ArticleGoogle Scholar
MacGee W: Metastatic and invasive tumours involving the heart in a geriatric population: a necropsy study. Virchows Arch A Pathol Anat Histol. 1991, 419: 183-189. 10.1007/BF01626346.View ArticleGoogle Scholar
Scott RW, Garvin CF: Tumors of the heart and pericardium. Am Heart J. 1939, 17: 431-436. 10.1016/S0002-8703(39)90593-4.View ArticleGoogle Scholar
Bisel HF, Wróblewski F, LaDue JS: Incidence and clinical manifestations of cardiac metastases. JAMA. 1953, 153: 712-715. 10.1001/jama.1953.02940250018005.View ArticleGoogle Scholar
Prichard RW: Tumors of the heart. Review of the subject and report of one hundred and fifty cases. Arch Pathol. 1951, 51: 98-128.Google Scholar
Young JM, Goldman IR: Tumor metastasis to the heart. Circulation. 1954, 9: 220-229. 10.1161/01.CIR.9.2.220.View ArticlePubMedGoogle Scholar
Lockwood WB, Broghamer WL: The changing prevalence of secondary cardiac neoplasms as related to cancer therapy. Cancer. 1980, 45: 2659-2662. 10.1002/1097-0142(19800515)45:10<2659::AID-CNCR2820451029>3.0.CO;2-A.View ArticlePubMedGoogle Scholar
Lam KY, Dickens P, Chan ACL: Tumors of the heart. A 20-year experience with a review of 12485 consecutive autopsies. Arch Pathol Lab Med. 1993, 117: 1027-1031.PubMedGoogle Scholar
Virmani R: Atlas of tumour pathology. Tumours of the heart and great vessels. Edited by: Burke A, Virmani R. 1995, Washington, DC: AFIP, 195-209. Tumours metastatic to the heart and pericardium, rd Series Fascicle 16Google Scholar
McAllister HA: Tumours of the heart and pericardium. Cardiovascular pathology. Volume 2. Edited by: Silver MD. 1991, New York, NY: Churchill Livingstone, 1297-1333. 2Google Scholar
Wenger NK: Pericardial disease in the elderly. Cardiovasc Clin. 1992, 22: 97-103.PubMedGoogle Scholar
Nakayama R, Yoneyama T, Takatani O, Kimura K: A study of metastatic tumors to the heart, pericardium and great vessels. Jpn Heart J. 1966, 7: 227-234. 10.1536/ihj.7.227.View ArticlePubMedGoogle Scholar
Abraham KP, Reddy V, Gattuso P: Neoplasms metastatic to the heart: review of 3314 consecutive autopsies. Am J Cardiovasc Pathol. 1990, 3: 195-198.PubMedGoogle Scholar
Bussani R, De-Giorgio F, Abbate A, Silvestri F: Cardiac metastases. J Clin Pathol. 2007, 60: 27-34. 10.1136/jcp.2005.035105.PubMed CentralView ArticlePubMedGoogle Scholar
Gibbs P, Cebon JS, Calafiore P, Robinson WA: Cardiac metastases from malignant melanoma. Cancer. 1999, 85: 78-84. 10.1002/(SICI)1097-0142(19990101)85:1<78::AID-CNCR11>3.0.CO;2-5.View ArticlePubMedGoogle Scholar
Paget S: The distribution of secondary growths in cancer of the breast. Lancet. 1889, 1: 571-573.View ArticleGoogle Scholar
Ewing J: A treatise of tumors. 1928, Philadelphia, PA: SaundersGoogle Scholar
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Issue | Vol 57, No 1 (2019) | |
Section | Case Report(s) | |
DOI | https://doi.org/10.18502/acta.v57i1.1756 | |
Keywords | ||
Breast neoplasm metastasis Cardiac valve Tamponade Pericardial effusion |
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