The Characteristic Clinical and Pathological Features of Incidental and Non-Incidental Papillary Microcarcinoma of the Thyroid
-
Özgün Akgül
,
Erdinç Kamer
,
Turan Acar
,
Nihan Acar
,
Erdem Sarı
,
Yelda Dere
,
Özcan Dere
,
Ercüment Tarcan
,
Hüdai Genç
,
Mehmet Haciyanli
Abstract
The incidence of papillary microcarcinoma (PMC) keeps raising due to fine needle aspiration (FNA) biopsies and the pathologic evaluation of thyroid specimens of cases operated for benign thyroid disorders. The files of 78 patients who underwent surgery between January 2006 and May 2013 in our department and were diagnosed with PMC were analyzed, retrospectively.Cases were grouped as incidental and non-incidental depending on the preoperative diagnosis. The diameter of the nodules in the preoperativeultrasonographic examination, pathological parameters such as tumor size, bilaterality, multifocality,and capsular invasion were found significantly high in non-incidental group(P<0.05). No significant difference was detected between the two groups’ age, sex, and vascular invasion.Preoperative radiologic examination by experienced radiologists and FNA performed for suspicious nodules may increase the rate of early and correct diagnosis. In our opinion, determining the most useful criteria for malignancy will help to detect incidental PMC in cases followed up for multinodular goiter.
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http://www3.ha.org.hk/cancereg/
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8. Hundahl SA, Fleming ID, Fremgen AM, Menck HR. A National Cancer Data Base report on 53.856 cases of thyroid carcinoma treated in the US.,1985-1995. Cancer 1998;83:2638-48.
9. Fukunaga F, Yatani Y. Geographic pathology of occult tyroid carcinomas. Cancer Treat Rev 1975;36:1095-9.
10. Bozec A, Peyrottes I, Poissonnet G, Chamorey E, Mahdyoun P, Sudaka A, et al. Papillary thyroid microcarsinomas: review of 230 cases. Rev LarygngolOtolRhinol 2009;130:215-20.
11. Bramley MD, Harrison BJ.Papillarymicrocarsinoma of the thyroid gland. Br J Surg 1996;83:1674-83.
12. Vasileiadis I, Karatzas T, Vasileiadis D, Kapetanakis S, Charitoudis G, Karakostas E, et al. Clinical and pathological characteristics of incidental and nonincidental papillary thyroid microcarcinoma in 339 patients. Head Neck 2014;36:564-70.
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14. Kim BY, Jung CH, Kim JW, Lee SW, Kim CH, Kang SK, et al. Impact of clinicopatholojic factors on subclinical central lymph node metastasis in papillary thyoidmicrocarsinoma. Yonsei Med J 2012;53:924-30.
15. Roh JL, Kim JM, Park C. Lateral cervical lymph node metastasis from papillary thyroid carcinoma: Pattern of nodal metastases and optimal startegy for neck dissection. Ann SurgOncol 2008;15:1177-82.
16. Roh JL, Kim JM, Park C. Central cervical nodal metastasis from papillary thyroid mictrocarcinoma: Pattern and factors predictive of nodal metastasis Ann SurgOncol 2008;15:2482-6.
17. Londero SC, Krogdahl A, Bastholt L, Overgaard J, Trolle W, Pedersen HB, et al. Papillary thyroid microcarcinoma in Denmark 1996-2008: a national study of epidemiology and clinical significance. Thyroid 2013;23:1159-64.
18. Sadler TW. Langman’s Medical Embryology. Head and neck 11th ed. Maryland: Williams & Wilkins, 2009:363-403.
19. Wada N, Duh QY, Sugino K, Iwasaki H, Kameyama K, Mimura T, et al. Lymph node metastasis from 259 papillary thyroid microcarcinomas. Ann Surg 2003;237:399-407.
20. RohJL, Kim JM, Park C. Central cervical nodal metastasis from papillary thyroid mictrocarcinoma: Pattern and factors predictive of nodal metastasis. Ann SurgOncol 2008;15:2482-6.
21. Lombardi CP, Bellantone R, De Crea C, Paladino NC, Fadda G, Salvatori M, et al. Papillary thyroid microcarsinoma: extrathyroidal extension, lymph node metastases and risk factors for recurrence in a high prevalence of goiter area. World J Surg 2010;34:1214-21.
22. Elliott MS, Gao K, Gupta R, Chua EL, Gargya A, Clark J. Management of incidental and non-incidental papillary thyroid microcarcinoma. JlaryngolOtol 2013;127:S17-23.
23. Barbaro D, Simi U, Meucci G, Lapi P, Orsini P, Pasquini C. Thyroid papillary cancers: microcarcinoma and carcinoma, incidental cancers and non-incidental cancers - are they different diseases? ClinEndocrinol2005;63:577-81.
24. Pelizzo MR, Boschin IM, Toniato A, Pagetta C, Piotto A, Bernante P, et al. Natural history, diagnosis, treatment and outcome of papillary thyroid microcarcinoma (PTMC): a mono-institutional 12-year experience. Nucl Med Commun 2004;25:547-52.
25. Kasai N, Sakamoto A. New subgrouping of small thyroid carcinomas. Cancer Control 1987;60:1767-70.
26. Pellegriti G, Scollo C, Lumera G, Regalbuto C, Vigneri R, Belfiore A. Clinical behavior and outcome of papillary thyroid cancers smaller than 1.5cm in diameter: study of 299 cases. J ClinEndocrinolMetab 2004;89:3713-20.
27. Roti E, degliUberti EC, Bondanelli M, Braverman LE. Thyroid papillary microcarcinoma: a descriptive and meta-analysis study. Eur J Endocrinol 2008;159:659-73.
28. Baudin E, Travagli JP, Ropers J, Mancusi F, Bruno-Bossio G, Caillou B, et al. Microcarcinoma of the thyroid gland: the Gustave-Roussy Institute experience. Cancer 1998;83:553-9.
29. Chow SM, Law SC, Chan JK, Au SK, Yau S, Lau WH. Papillary microcarcinoma of the thyroid-Prognostic significance of lymph node metastasis and multifocality. Cancer 2003;98:31-40.
30. Shattuck TM, Westra WH, Ladenson PW, Arnold A. Independent clonal origins of distinct tumor foci in multifocal papillary thyroid carcinoma. N Engl J Med 2005;352:2406-12.
31. Miccoli P, Minuto MN, Galleri D, D'Agostino J, Basolo F, Antonangeli L, et al. Incidental thyroid carcinoma in a large series of consecutive patients operated on for benign thyroid disease. ANZ J Surg 2006;76:123-6.
2. Hedinger C, Williams ED, Sobin LH. Histological typing of thyroid tumors. World Health Organization. (Accsessed October 2018, 12, at http://apps.who.int/bookorders/anglais/detart1.jsp?codlan=4&codcol=25&codcch=1011).
3. Harach H, Franssila K, Wasenius V. Occult papillary carcinoma of the thyroid: a ‘normal’ finding in Finland; a systematic autopsy study. Cancer 1985;56:531-8.
4. Hay ID, Hutchinson ME, Gonzalez-Losada T, McIver B, Reinalda ME, Grant CS, et al. Papillary thyroid microcarcinoma: A study of 900 cases observed in a 60-year period. Surgery 2008;144:980-8.
5. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics. CA Cancer J Clin 2010;60:277-300.
6. Cancer incidance and mortality in Hong Kong. Hong Kong Cancer Registry. Hong Kong1983-2006.
http://www3.ha.org.hk/cancereg/
7. Carlini M, Giovannini C, Castaldi F, Mercadante E, Dell'Avanzato R, Zazza S, et al. High risk for microcarcinoma in thyroid benign diseases. Incidence in a one year period of total thyroidectomies. J ExpClin Cancer Res 2005;24:231-6.
8. Hundahl SA, Fleming ID, Fremgen AM, Menck HR. A National Cancer Data Base report on 53.856 cases of thyroid carcinoma treated in the US.,1985-1995. Cancer 1998;83:2638-48.
9. Fukunaga F, Yatani Y. Geographic pathology of occult tyroid carcinomas. Cancer Treat Rev 1975;36:1095-9.
10. Bozec A, Peyrottes I, Poissonnet G, Chamorey E, Mahdyoun P, Sudaka A, et al. Papillary thyroid microcarsinomas: review of 230 cases. Rev LarygngolOtolRhinol 2009;130:215-20.
11. Bramley MD, Harrison BJ.Papillarymicrocarsinoma of the thyroid gland. Br J Surg 1996;83:1674-83.
12. Vasileiadis I, Karatzas T, Vasileiadis D, Kapetanakis S, Charitoudis G, Karakostas E, et al. Clinical and pathological characteristics of incidental and nonincidental papillary thyroid microcarcinoma in 339 patients. Head Neck 2014;36:564-70.
13. Roti E, Rossi R, Trasforini G, Bertelli F, Ambrosio MR, Busutti L, et al. Clinical and histological characteristics of papillary thyroid microcarcinoma: Results of a retrospective study in 243 patients. J ClinEndocrinolMetab 2006;91:2171-8.
14. Kim BY, Jung CH, Kim JW, Lee SW, Kim CH, Kang SK, et al. Impact of clinicopatholojic factors on subclinical central lymph node metastasis in papillary thyoidmicrocarsinoma. Yonsei Med J 2012;53:924-30.
15. Roh JL, Kim JM, Park C. Lateral cervical lymph node metastasis from papillary thyroid carcinoma: Pattern of nodal metastases and optimal startegy for neck dissection. Ann SurgOncol 2008;15:1177-82.
16. Roh JL, Kim JM, Park C. Central cervical nodal metastasis from papillary thyroid mictrocarcinoma: Pattern and factors predictive of nodal metastasis Ann SurgOncol 2008;15:2482-6.
17. Londero SC, Krogdahl A, Bastholt L, Overgaard J, Trolle W, Pedersen HB, et al. Papillary thyroid microcarcinoma in Denmark 1996-2008: a national study of epidemiology and clinical significance. Thyroid 2013;23:1159-64.
18. Sadler TW. Langman’s Medical Embryology. Head and neck 11th ed. Maryland: Williams & Wilkins, 2009:363-403.
19. Wada N, Duh QY, Sugino K, Iwasaki H, Kameyama K, Mimura T, et al. Lymph node metastasis from 259 papillary thyroid microcarcinomas. Ann Surg 2003;237:399-407.
20. RohJL, Kim JM, Park C. Central cervical nodal metastasis from papillary thyroid mictrocarcinoma: Pattern and factors predictive of nodal metastasis. Ann SurgOncol 2008;15:2482-6.
21. Lombardi CP, Bellantone R, De Crea C, Paladino NC, Fadda G, Salvatori M, et al. Papillary thyroid microcarsinoma: extrathyroidal extension, lymph node metastases and risk factors for recurrence in a high prevalence of goiter area. World J Surg 2010;34:1214-21.
22. Elliott MS, Gao K, Gupta R, Chua EL, Gargya A, Clark J. Management of incidental and non-incidental papillary thyroid microcarcinoma. JlaryngolOtol 2013;127:S17-23.
23. Barbaro D, Simi U, Meucci G, Lapi P, Orsini P, Pasquini C. Thyroid papillary cancers: microcarcinoma and carcinoma, incidental cancers and non-incidental cancers - are they different diseases? ClinEndocrinol2005;63:577-81.
24. Pelizzo MR, Boschin IM, Toniato A, Pagetta C, Piotto A, Bernante P, et al. Natural history, diagnosis, treatment and outcome of papillary thyroid microcarcinoma (PTMC): a mono-institutional 12-year experience. Nucl Med Commun 2004;25:547-52.
25. Kasai N, Sakamoto A. New subgrouping of small thyroid carcinomas. Cancer Control 1987;60:1767-70.
26. Pellegriti G, Scollo C, Lumera G, Regalbuto C, Vigneri R, Belfiore A. Clinical behavior and outcome of papillary thyroid cancers smaller than 1.5cm in diameter: study of 299 cases. J ClinEndocrinolMetab 2004;89:3713-20.
27. Roti E, degliUberti EC, Bondanelli M, Braverman LE. Thyroid papillary microcarcinoma: a descriptive and meta-analysis study. Eur J Endocrinol 2008;159:659-73.
28. Baudin E, Travagli JP, Ropers J, Mancusi F, Bruno-Bossio G, Caillou B, et al. Microcarcinoma of the thyroid gland: the Gustave-Roussy Institute experience. Cancer 1998;83:553-9.
29. Chow SM, Law SC, Chan JK, Au SK, Yau S, Lau WH. Papillary microcarcinoma of the thyroid-Prognostic significance of lymph node metastasis and multifocality. Cancer 2003;98:31-40.
30. Shattuck TM, Westra WH, Ladenson PW, Arnold A. Independent clonal origins of distinct tumor foci in multifocal papillary thyroid carcinoma. N Engl J Med 2005;352:2406-12.
31. Miccoli P, Minuto MN, Galleri D, D'Agostino J, Basolo F, Antonangeli L, et al. Incidental thyroid carcinoma in a large series of consecutive patients operated on for benign thyroid disease. ANZ J Surg 2006;76:123-6.
| Files | ||
| Issue | Vol 57, No 1 (2019) | |
| Section | Articles | |
| DOI | https://doi.org/10.18502/acta.v57i1.1755 | |
| Keywords | ||
| Incidental Non-incidental Papillary microcarcinoma Thyroid | ||
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How to Cite
1.
Akgül Özgün, Kamer E, Acar T, Acar N, Sarı E, Dere Y, Dere Özcan, Tarcan E, Genç H, Haciyanli M. The Characteristic Clinical and Pathological Features of Incidental and Non-Incidental Papillary Microcarcinoma of the Thyroid. Acta Med Iran. 2019;57(1):63-67.
