Gender-Age Disparity of Cancers' Incidence in Iran
Cancer is one of the leading causes of death worldwide and among Iranian population; cancer is the third important causes of death. It is a critical issue to identify sex and age group difference of cancer pattern for planning and management of cancer patients, therefore the aim of present study was to examine sex and age difference in cancer incidence during 2003-2008 in Iran. The National Cancer Registry (NCR) reports from 2003 to 2008 have been applied to test trend of cancer incidence and illustrating sex-age disparity of most common cancers in Iran. Direct adjustment method was used for computing the age-specific rates (ASRs) and Cochran-Armitage tests for trends were used to test statistical significance of cancer incidence rate in both genders during 2003-2008. Our findings indicated that male and female incidence rate is increased from 64.2 to 117.5 and from 50.1 to 105.8, respectively during 2003-2008 (P for trend <0.001). Highest Age-Specific Rate of cancer in male was for stomach cancer (ASR=12.8), beside of skin cancer and in female was for breast cancer (ASR=33.2). Highest incidence rate of cancers was found in people aged 80-84 years in both genders. In elderly people, incidence rate of cancer was higher in male than female. The observed sex-age disparity of common cancers in this study indicated that male cancer of stomach and bladder and female cancer of breast and colorectal can be targeted in cancer control and prevention programs are required to reach remarkable reduction of cancer burden in Iran.
2. Saadat S, Yousefifard M, Asady H, Jafari AM, Fayaz M, Hosseini M. The most important causes of death in Iranian population; a retrospective cohort study. Emerg (Tehran) 2015;3:16-21.
3. Dorak MT, Karpuzoglu E. Gender differences in cancer susceptibility: an inadequately addressed issue. Front Genet 2012;3:268.
4. Biggar RJ, Bergen AW, Poulsen GN. Impact of X chromosome genes in explaining the excess risk of cancer in males. Am J Epidemiol 2009;170:65-71.
5. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin 2016;66:7-30.
6. Armitage P, Doll R. The age distribution of cancer and a multi-stage theory of carcinogenesis. Br J Cancer 1954;8:1-12.
7. Krieger N. Genders, sexes, and health: what are the connections and why does it matter? Int J Epidemiol 2003;32:652-7.
8. Benigni R. Social sexual inequality and sex difference in cancer incidence. Environ Res 2007;104:128-34.
9. Zhang Y, Klein K, Sugathan A, Nassery N, Dombkowski A, Zanger UM, et al. Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease. PLoS One 2011;6:e23506.
10. Pakzad R, Mohammadian-Hafshejani A, Mohammadian M, Pakzad I, Safiri S, Khazaei S, et al. Incidence and mortality of bladder cancer and their relationship with development in Asia. Asian Pac J Cancer Prev 2015;16:7365-74.
11. Khazaei S, Rezaeian S, Soheylizad M, Khazaei S, Biderafsh A. Global incidence and mortality rates of stomach cancer and the human development index: an ecological study. Asian Pac J Cancer Prev 2016;17:1701-4.
12. Khazaei S, Rezaeian S, Ayubi E, Gholamaliee B, Pishkuhi MA, Khazaei S, et al. Global prostate cancer incidence and
mortality rates according to the Human Development Index. Asian Pac J Cancer Prev 2016;17:3793-6.
13. Khazaei S, Rezaeian S, Mansori K, Sanjari MA, Ayubi E. Effects of Human Development Index and Its Components on Colorectal Cancer Incidence and Mortality: a Global Ecological Study. Asian Pacific journal of cancer prevention: APJCP 2015;17:253-6.
14. Shuja M, Islamie Farsani S, Salehiniya H, Khazaei S, Mohammadian M, Aryaie M, et al. Assessment the association between liver cancer incidence and mortality rate with human development index in the European countries in 2012. Biomed Res Ther 2017.
15. Khazaei S, Rezaeian S, Khazaei Z, Molaeipoor L, Nematollahi S, Lak P, et al. National breast cancer mortality and incidence rates according to the human development index: an ecological Study. Adv Breast Cancer Res 2016;5:30-6.
16. Mousavi SM, Gouya MM, Ramazani R, Davanlou M, Hajsadeghi N, Seddighi Z. Cancer incidence and mortality in Iran. Ann Oncol 2009;20:556-63.
17. Boyle P, Levin B. World cancer report 2008: IARC Press, International Agency for Research on Cancer; 2008.
18. Bilimoria KY, Stewart AK, Winchester DP, Ko CY. The National Cancer Data Base: a powerful initiative to improve cancer care in the United States. Ann Surg Oncol 2008;15:683-90.
19. Wu A, Paganini-Hill A, Ross R, Henderson B. Alcohol, physical activity and other risk factors for colorectal cancer: a prospective study. Br J Cancer 1987;55:687.
20. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127:2893-917.
21. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011;61:69-90.
22. Zohal M, Ghorbani A, Esmailzadehha N, Ziaee A, Mohammadi Z. Association of sleep quality components and wake time with metabolic syndrome: The Qazvin Metabolic Diseases Study (QMDS), Iran. Diabetes Metab Syndr 2017;11:S377-80.
23. Alikhani S, Delavari A, Alaedini F, Kelishadi R, Rohbani S, Safaei A. A province-based surveillance system for the risk factors of non-communicable diseases: A prototype for integration of risk factor surveillance into primary healthcare systems of developing countries. Public Health 2009;123:358-64.
24. Derakhshan MH, Malekzadeh R, Watabe H, Yazdanbod A, Fyfe V, Kazemi A, et al. Combination of gastric atrophy, reflux symptoms and histological subtype indicates twodistinct aetiologies of gastric cardia cancer. Gut 2008;57:298-305.
25. Ansari R, Mahdavinia M, Sadjadi A, Nouraie M, Kamangar F, Bishehsari F, et al. Incidence and age distribution of colorectal cancer in Iran: results of a population-based cancer registry. Cancer Lett 2006;240:143-7.
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