Different Breast Cancer Subtypes in Women More Than 65-Year-Old

  • Arezoo Sanaee Pour General Practitioner, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Leila Pourali Mail Department of Obstetrics and Gynecology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran .
  • Mona Joudi Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Ali Taghizadeh Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Maryam Salehi Department of Socio-Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Mehrdad Gazanchian Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Golshid Nouri Hosseini Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Keywords:
Breast cancer, Diagnosis, Age, Metastasis

Abstract

Breast cancer is the most common malignancy of females. Breast cancer is a heterogenic disease; it consists of several subtypes based on the expression of different genes. Risk factors associated with each subtype is not completely understood, yet. Moreover, recognizing the cancer subtypes may alter the treatment plan. The aim of this study was to evaluate different breast cancer subtypes in women more than 65-year-old. This was a cross-sectional study done on patients with breast cancer aged 65 years and older presenting to clinics of Emam Reza and Omid Hospitals, Mashhad, Iran between 2005 and 2015. Statistical analysis was carried out using SPSS ver. 16. P<0.05 was considered statistically significant.A total of 225 breast cancer patients age 65 and older were included in our study. When we categorized our patients by breast cancer subtypes, 69.8% had the Luminal A, B subtype, 23.1% had Triple-Negative subtype, and the remaining 7.1% had HER-2 enriched subtype.Different breast cancer subtypes in patients aged 65-year-old and higher were Luminal A, B, HER-2 enriched and Triple-negative, respectively. We also showed that patients with Luminal A, B subtypes had significantly higher BMI and BSA compared to other subtypes.

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Published
2019-01-15
How to Cite
1.
Sanaee Pour A, Pourali L, Joudi M, Taghizadeh A, Salehi M, Gazanchian M, Nouri Hosseini G. Different Breast Cancer Subtypes in Women More Than 65-Year-Old. Acta Med Iran. 56(11):698-703.
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