Original Article

Different Breast Cancer Subtypes in Women More Than 65-Year-Old

Abstract

Breast cancer is the most common malignancy of females. Breast cancer is a heterogenic disease; it consists of several subtypes based on the expression of different genes. Risk factors associated with each subtype is not completely understood, yet. Moreover, recognizing the cancer subtypes may alter the treatment plan. The aim of this study was to evaluate different breast cancer subtypes in women more than 65-year-old. This was a cross-sectional study done on patients with breast cancer aged 65 years and older presenting to clinics of Emam Reza and Omid Hospitals, Mashhad, Iran between 2005 and 2015. Statistical analysis was carried out using SPSS ver. 16. P<0.05 was considered statistically significant.A total of 225 breast cancer patients age 65 and older were included in our study. When we categorized our patients by breast cancer subtypes, 69.8% had the Luminal A, B subtype, 23.1% had Triple-Negative subtype, and the remaining 7.1% had HER-2 enriched subtype.Different breast cancer subtypes in patients aged 65-year-old and higher were Luminal A, B, HER-2 enriched and Triple-negative, respectively. We also showed that patients with Luminal A, B subtypes had significantly higher BMI and BSA compared to other subtypes.

1. Simpson JS, Briggs K, George R. Breast Cancer amongst Filipino migrants: A review of the literature and ten-year institutional analysis. J Immigr Minor Health 2015;17:729-36.
2. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet‐Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin 2015;65:87-108.
3. Mousavi SM, Montazeri A, Mohagheghi MA, Jarrahi AM, Harirchi I, Najafi M, et al. Breast cancer in Iran: an epidemiological review. Breast J 2007;13:383-91.
4. Sadjadi A, Nouraie M, Ghorbani A, Alimohammadian M, Malekzadeh R. Epidemiology of breast cancer in the Islamic Republic of Iran: first results from a population-based cancer registry. East Mediterr Health J 2009;15:1426-31.
5. Bloom H, Richardson W. Histological grading and prognosis in breast cancer: a study of 1409 cases of which 359 have been followed for 15 years. Br JCancer1957;11:359-77.
6. Kurebayashi J, Moriya T, Ishida T, Hirakawa H, Kurosumi M, Akiyama F, et al. The prevalence of intrinsic subtypes and prognosis in breast cancer patients of different races. Breast 2007;16:72-7.
7. Barnard ME, Boeke CE, Tamimi RM. Established breast cancer risk factors and risk of intrinsic tumor subtypes. BiochimBiophysActa2015;1856:73-85.
8. Osborne CK, Yochmowitz MG, Knight III WA, McGuire WL. The value of estrogen and progesterone receptors in the treatment of breast cancer. Cancer 1980;46:2884-8.
9. Ihemelandu CU, Leffall LD, Dewitty RL, Naab TJ, Mezghebe HM, Makambi KH, et al. Molecular breast cancer subtypes in premenopausal and postmenopausal African-American women: age-specific prevalence and survival. J Surg Res 2007;143:109-18.
10. Kwan ML, Kushi LH, Weltzien E, Maring B, Kutner SE, Fulton RS, et al. Epidemiology of breast cancer subtypes in two prospective cohort studies of breast cancer survivors. Breast Cancer Res2009;11:R31.
11. Carey LA, Perou CM, Livasy CA, Dressler LG, Cowan D, Conway K, et al. Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA 2006;295:2492-502.
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IssueVol 56, No 11 (2018) QRcode
SectionOriginal Article(s)
Keywords
Breast cancer Diagnosis Age Metastasis
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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Sanaee Pour A, Pourali L, Joudi M, Taghizadeh A, Salehi M, Gazanchian M, Nouri Hosseini G. Different Breast Cancer Subtypes in Women More Than 65-Year-Old. Acta Med Iran. 2019;56(11):698-703.