Association Between a 50bp Ins/Del Genetic Variation at Promoter of the Superoxide Dismutase-1 (SOD1) and the Risk of Dependency to Opium and Methamphetamine
Abstract
Superoxide dismutase-1 (SOD1, OMIM: 147450, copper-zinc superoxide dismutase) is one of the major antioxidant enzymes, which plays an important role in clearance of reactive oxygen species. A common genetic polymorphism of 50 bp insertion/deletion (Ins/Del) in the promoter region of the SOD1 has been reported. The purpose of the present study was to investigate the association between this polymorphism and the risk of opium (OD) and methamphetamine (MD) dependency. The present report was consisted of two case-control studies. The first study consisted of 143 OD subjects and 570 healthy controls. The second study consisted of 65 cases with MD and 635 controls. The controls were selected randomly from the healthy blood donors. Genotyping were carried out using PCR based method. Statistical analysis indicated that neither the Ins/Del (OR=1.06, 95% CI: 0.69-1.62, P=0.788) nor the Del/Del (OR=0.57, 95% CI: 0.13-2.55, P=0.464) genotypes were associated with the risk of OD. Although the frequency of the Ins/Del genotype was lower among methamphetamine-dependent persons compared to healthy control subjects, there was no significant association between the Ins/Del polymorphism and the risk of MD (OR=0.82, 95% CI: 0.44-1.53, P=0.547). The present findings demonstrated that the SOD1 50bp Ins/Del polymorphism is not associated with the risk of OD and MD.
Niwa J, Yamada S, Ishigaki S, Sone J, Takahashi M, Katsuno M, Tanaka F, Doyu M, Sobue G. Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1. J Biol Chem. 2007;282:28087-28095.
Smaga I, Niedzielska E, Gawlik M, Moniczewski A, Krzek J, Przegaliński E, Pera J, Filip M. Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism. Pharmacol Rep. 2015;67:569-580.
Ghazavi A, Mosayebi G, Solhi H, Rafiei M, Moazzeni SM. Serum markers of inflammation and oxidative stress in chronic opium (Taryak) smokers. Immunol Lett. 2013;153:22-26.
Soykut B, Eken A, Erdem O, Akay C, Aydın A, Çetin MK, Dilbaz N. Oxidative stress enzyme status and frequency of micronuclei in heroin addicts in Turkey. Toxicol Mech Methods. 2013;23:684-688.
El-Kheshen G, Moeini M, Saadat M. Susceptibility to ulcerative colitis and genetic polymorphisms of A251G SOD1 and C-262T CAT. J Med Biochem. 2016;35:333-336.
Rajkumar S, Vasavada AR, Praveen MR, Ananthan R, Reddy GB, Tripathi H, Ganatra DA, Arora AI, Patel AR. Exploration of molecular factors impairing superoxide dismutase isoforms activity in human senile cataractous lenses. Invest Ophthalmol Vis Sci. 2013;54:6224-6233.
Kasznicki J, Sliwinska A, Kosmalski M, Merecz A, Majsterek I, Drzewoski J. Genetic polymorphisms (Pro197Leu of Gpx1, +35A/C of SOD1, -262C/T of CAT), the level of antioxidant proteins (GPx1, SOD1, CAT) and the risk of distal symmetric polyneuropathy in Polish patients with type 2 diabetes mellitus. Adv Med Sci. 2016;61:123-129.
Spisak K, Klimkowicz-Mrowiec A, Pera J, Dziedzic T, Aleksandra G, Slowik A. rs2070424 of the SOD1 gene is associated with risk of Alzheimer's disease. Neurol Neurochir Pol. 2014;48:342-345.
Jamhiri I, Saadat I, Omidvari S. Genetic polymorphisms of superoxide dismutase-1 A251G and catalase C-262T with the risk of colorectal cancer. Mol Biol Res Commun. 2017;6:85-90.
Eskandari-Nasab E, Kharazi-Nejad E, Nakhaee A, Afzali M, Tabatabaei SP, Tirgar-Fakheri K, Hashemi M. 50-bp Ins/Del polymorphism of SOD1 is associated with increased risk of cardiovascular disease. Acta Med Iran. 2014;52:591-595.
Kordestanian N, Saadat M. A 50-bp Ins/Del polymorphism at the promoter region of the superoxide dismutase-1 and bipolar disorder type 1. Nordic J Psychiatry. 2017;71:750-753.
Broom WJ, Greenway M, Sadri-Vakili G, Russ C, Auwarter KE, Glajch KE, Dupre N, Swingler RJ, Purcell S, Hayward C, Sapp PC, McKenna-Yasek D, Valdmanis PN, Bouchard JP, Meininger V, Hosler BA, Glass JD, Polack M, Rouleau GA, Cha JH, Hardiman O, Brown RH Jr. 50bp deletion in the promoter for superoxide dismutase 1 (SOD1) reduces SOD1 expression in vitro and may correlate with increased age of onset of sporadic amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2008;9:229-237.
Ingre C, Wuolikainen A, Marklund SL, Birve A, Press R, Andersen PM. A 50 bp deletion in the SOD1 promoter lowers enzyme expression but is not associated with ALS in Sweden. Amyotroph Lateral Scler Frontotemporal Degener. 2016;22:1-6.
Saify K, Saadat M. Influence of a 50bp Ins/Del polymorphism at promoter of the superoxide dismutase-1 on gene expression and risk of heroin dependency. Environ Health Prev Med. 2017;22:24.
Ma J, Yuan X, Qu H, Zhang J, Wang D, Sun X, Zheng Q. The role of reactive oxygen species in morphine addiction of SH-SY5Y cells. Life Sci. 2015;124:128-135.
Hool LC. Evidence for the regulation of L-type Ca2+ channels in the heart by reactive oxygen species: mechanism for mediating pathology. Clin Exp Pharmacol Physiol. 2008;35:229-234.
Pardo CA, Xu Z, Borchelt DR, Price DL, Sisodia SS, Cleveland DW. Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons. Proc Nat Acad Sci USA. 1995;92:954-958.
Saify K, Saadat M. Expression patterns of antioxidant genes in human SH-SY5Y cells after treatment with methadone. Psychiatry Res. 2015;230:116-119.
Saify K, Saadat I, Saadat M. Down-regulation of antioxidant genes in human SH-SY5Y cells after treatment with morphine. Life Sci. 2016;144:26-29.
Saify K, Saadat M. Expression levels of antioxidant genes in human SH-SY5Y cells long term exposed to methadone. Turk J Biochem. 2016;41:493-494.
Nakatome M, Miyaji A, Mochizuki K, Kishi Y, Isobe I, Matoba R. Association between the GST genetic polymorphisms and methamphetamine abusers in the Japanese population. Leg Med (Tokyo). 2009;11:468-470.
Khalighinasab MR, Saify K, Saadat M. Association between GSTM1 and GSTT1 genetic polymorphisms and susceptibility to methamphetamine dependence. Mol Biol Res Commun. 2015:4:25-32.
Khalighinasab MR, Saify K, Saadat M. Association between null alleles of GSTM1 and GSTT1 and dependence to heroin and opium. Psychiatry Res. 2015;228:977-978.
Saify K, Khalighinasab MR, Saadat M. No association between GSTM1 and GSTT1 genetic polymorphisms and susceptibility to opium sap dependence Mol Biol Res Commun. 2016;5:59-64.
Koizumi H, Hashimoto K, Kumakiri C, Shimizu E, Sekine Y, Ozaki N, Inada T, Harano M, Komiyama T, Yamada M, Sora I, Ujike H, Takei N, Iyo M. Association between the glutathione S-transferase M1 gene deletion and female methamphetamine abusers. Am J Med Genet B Neuropsychiatr Genet. 2004;126B:43-45.
Saify K, Saadat I, Saadat M. Influence of A-21T and C-262T genetic polymorphisms at the promoter region of the catalase (CAT) on gene expression. Environ Health Prev Med. 2016;21:382-386.
Boroumand F, Saadat M. Lack of association between two genetic polymorphisms of SOD2 (rs2758339 and rs5746136) and the risk of opium dependency. Pol Ann Med. 2017;24:194-198.
Boroumand F, Mahmoudinasab, H, Saadat M. Association of the SOD2 (rs2758339 and rs5746136) polymorphisms with the risk of heroin dependency and the SOD2 expression levels. Gene. 2018;649:27-31.
Rafiee L, Saadat I, Saadat M. Glutathione S-transferase genetic polymorphisms (GSTM1, GSTT1 and GSTO2) in three Iranian populations. Mol Biol Rep. 2010;37:155-158.
Saadat M. Distribution of ACE insertion/deletion (I/D) polymorphism in Iranian populations. Mol Biol Res Commun. 2015;4:63-66.
Fallahzadeh-Abarghooei L, Zahedi T, Mirabedi F, Saadat M. Alleleic prevalence of intron 3 insertion/deletion genetic polymorphism of DNA double-strand break repair gene XRCC4 in four Iranian populations. Egypt J Med Hum Genet. 2015;16:215-218.
Nasseri G, Zahedi T, Mousavi-Kazerooni F, Saadat M. Prevalence of null genotypes of glutathione S-transferase T1 (GSTT1) and M1 (GSTM1) in seven Iranian populations. Iran J Public Health. 2015;44:1655-1661.
Ajonijebu DC, Abboussi O, Russell VA, Mabandla MV, Daniels WM. Epigenetics: a link between addiction and social environment. Cell Mol Life Sci. 2017;74:2735-2747.
Badiani A, Spagnolo PA. Role of environmental factors in cocaine addiction. Curr Pharm. 2013;19:6996-7008.
Mahmoudinasab, H, Saadat M. Expressions of some antioxidant genes in SH-SY5Y cells treated with β-lapachone, morphine and electromagnetic field. Mol Biol Rep. 2018; . doi: 10.1007/s11033-018-4172-1.
Saw CL, Cintrón M, Wu TY, Guo Y, Huang Y, Jeong WS, Kong AN. Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates. Biopharm Drug Dispos. 2011;32:289-300.
Mahmoudinasab H, Saadat M. Electromagnetic field could protect SH-SY5Y cells against cisplatin cytotoxicity, but not MCF-7 cells. DNA Cell Biol. 2018;37:330-335.
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| Issue | Vol 56, No 10 (2018) | |
| Section | Articles | |
| Keywords | ||
| Drug-dependent Ins/Del Polymorphism SOD1 | ||
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