A Rare Case Report of Postmenopausal Virilization: Ovarian Steroid Cell Tumor

  • Mahbube Ebrahimpur Department of Internal Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Mohammad Reza Mohajeri-Tehrani Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Science Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Hiva Saffar Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Mahnaz Pejman Sani Mail Department of Internal Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Hyperandrogenism, Postmenopause, Stromal luteoma


Ovarian steroid cell tumors are rare, life-threatening neoplasms that make about 0.1% of all primary ovarian tumors. They frequently present in premenopausal women with the manifestation of virilization. We report a 58-year-old postmenopausal woman that referred to our clinic with clinical manifestation of virilization. Laboratory findings showed markedly elevated serum testosterone level and ultrasound showed 2 follicles with 7 mm diameters in the left ovary. She treated by bilateral salpingo-oophorectomy and synchronous hysterectomy. Histological pathology confirmed a benign steroid cell tumor. The presentation of new-onset and rapid progressive hyperandrogenism is rare in postmenopausal women. In diagnosis, we must consider adrenal and ovarian malignancies. Stromal luteoma is a rare benign ovarian tumor, Which is treated with surgical treatment.


1. Grau Piera, S., et al., Clinical manifestation, diagnosis and histology of ovarian luteoma: case report of female virilisation and review of the literature. J Genit Syst Disor, 2015. 4(4).
2. Uyking-Naranjo, M. and R. Mirasol, Ovarian Stromal Tumors: A Rare Cause of Postmenopausal Virilization. Journal of the ASEAN Federation of Endocrine Societies, 2014. 28(1): p. 78.
3. Stephens, J., et al., An unusual steroid-producing ovarian tumour: case report. Human Reproduction, 2002. 17(6): p. 1468-1471.
4. Sielert, L., et al., Androgen-producing steroid cell ovarian tumor in a young woman and subsequent spontaneous pregnancy. Journal of assisted reproduction and genetics, 2013. 30(9): p. 1157-1160.
5. Horta, M. and T.M. Cunha, Sex cord-stromal tumors of the ovary: a comprehensive review and update for radiologists. Diagnostic and Interventional Radiology, 2015. 21(4): p. 277.
6. Hannibal, C.G., et al., A nationwide study of serous “borderline” ovarian tumors in Denmark 1978–2002: centralized pathology review and overall survival compared with the general population. Gynecologic oncology, 2014. 134(2): p. 267-273.
7. Numanoglu, C., et al., Stromal luteoma of the ovary: A rare ovarian pathology. Journal of Obstetrics and Gynaecology, 2015. 35(4): p. 420-421.
8. Mehdi, G., et al., Ovarian steroid cell tumour: correlation of histopathology with clinicopathologic features. Pathology research international, 2011. 2011.
9. Bhagat, R., et al., Steroid Cell Tumour of Ovary–A Rare Case Report. Journal of clinical and diagnostic research: JCDR, 2016. 10(9): p. ED06.
10. Rosner, W., et al., Utility, limitations, and pitfalls in measuring testosterone: an Endocrine Society position statement. The Journal of Clinical Endocrinology & Metabolism, 2006. 92(2): p. 405-413.
11. Demidov, V., et al., Imaging of gynecological disease (2): clinical and ultrasound characteristics of Sertoli cell tumors, Sertoli–Leydig cell tumors and Leydig cell tumors. Ultrasound in Obstetrics & Gynecology, 2008. 31(1): p. 85-91.
12. Faria, A.M., et al., A premenopausal woman with virilization secondary to an ovarian Leydig cell tumor. Nature Reviews Endocrinology, 2011. 7(4): p. 240-245.
How to Cite
Ebrahimpur M, Mohajeri-Tehrani MR, Saffar H, Pejman Sani M. A Rare Case Report of Postmenopausal Virilization: Ovarian Steroid Cell Tumor. Acta Med Iran. 57(12):728-730.
Case Report(s)